Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10391
Gene name	Coronin 2B
Gene symbol	CORO2B
Synonyms (NCBI Gene)	CLIPINC
Chromosome	15
Chromosome location	15q23

255

Show/Hide all (255)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004703	hsa-miR-185-5p	FlowImmunoblotMicroarrayqRT-PCR	19688090
MIRT017553	hsa-miR-335-5p	Microarray	18185580
MIRT024407	hsa-miR-215-5p	Microarray	19074876
MIRT026427	hsa-miR-192-5p	Microarray	19074876
MIRT904706	hsa-miR-106a	CLIP-seq
MIRT904707	hsa-miR-106b	CLIP-seq
MIRT904708	hsa-miR-1288	CLIP-seq
MIRT904709	hsa-miR-17	CLIP-seq
MIRT904710	hsa-miR-1915	CLIP-seq
MIRT904711	hsa-miR-20a	CLIP-seq
MIRT904712	hsa-miR-20b	CLIP-seq
MIRT904713	hsa-miR-2355-5p	CLIP-seq
MIRT904714	hsa-miR-298	CLIP-seq
MIRT904715	hsa-miR-3158-5p	CLIP-seq
MIRT904716	hsa-miR-3169	CLIP-seq
MIRT904717	hsa-miR-3609	CLIP-seq
MIRT904718	hsa-miR-3918	CLIP-seq
MIRT904719	hsa-miR-4297	CLIP-seq
MIRT904720	hsa-miR-4418	CLIP-seq
MIRT904721	hsa-miR-4685-5p	CLIP-seq
MIRT904722	hsa-miR-4796-3p	CLIP-seq
MIRT904723	hsa-miR-509-3-5p	CLIP-seq
MIRT904724	hsa-miR-509-5p	CLIP-seq
MIRT904725	hsa-miR-519d	CLIP-seq
MIRT904726	hsa-miR-548ah	CLIP-seq
MIRT904727	hsa-miR-93	CLIP-seq
MIRT904706	hsa-miR-106a	CLIP-seq
MIRT904707	hsa-miR-106b	CLIP-seq
MIRT904728	hsa-miR-1229	CLIP-seq
MIRT904708	hsa-miR-1288	CLIP-seq
MIRT904709	hsa-miR-17	CLIP-seq
MIRT904711	hsa-miR-20a	CLIP-seq
MIRT904712	hsa-miR-20b	CLIP-seq
MIRT904729	hsa-miR-2392	CLIP-seq
MIRT904714	hsa-miR-298	CLIP-seq
MIRT904715	hsa-miR-3158-5p	CLIP-seq
MIRT904730	hsa-miR-3161	CLIP-seq
MIRT904716	hsa-miR-3169	CLIP-seq
MIRT904731	hsa-miR-3180-5p	CLIP-seq
MIRT904732	hsa-miR-3192	CLIP-seq
MIRT904733	hsa-miR-3605-5p	CLIP-seq
MIRT904717	hsa-miR-3609	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT904736	hsa-miR-3689d	CLIP-seq
MIRT904737	hsa-miR-382	CLIP-seq
MIRT904720	hsa-miR-4418	CLIP-seq
MIRT904738	hsa-miR-4534	CLIP-seq
MIRT904739	hsa-miR-4695-3p	CLIP-seq
MIRT904740	hsa-miR-4728-5p	CLIP-seq
MIRT904722	hsa-miR-4796-3p	CLIP-seq
MIRT904741	hsa-miR-4802-5p	CLIP-seq
MIRT904723	hsa-miR-509-3-5p	CLIP-seq
MIRT904724	hsa-miR-509-5p	CLIP-seq
MIRT904725	hsa-miR-519d	CLIP-seq
MIRT904742	hsa-miR-520a-5p	CLIP-seq
MIRT904743	hsa-miR-525-5p	CLIP-seq
MIRT904744	hsa-miR-526b	CLIP-seq
MIRT904726	hsa-miR-548ah	CLIP-seq
MIRT904745	hsa-miR-570	CLIP-seq
MIRT904746	hsa-miR-592	CLIP-seq
MIRT904747	hsa-miR-597	CLIP-seq
MIRT904727	hsa-miR-93	CLIP-seq
MIRT1921454	hsa-miR-3929	CLIP-seq
MIRT1921455	hsa-miR-4419b	CLIP-seq
MIRT1921456	hsa-miR-4478	CLIP-seq
MIRT1921457	hsa-miR-4766-5p	CLIP-seq
MIRT904722	hsa-miR-4796-3p	CLIP-seq
MIRT1968302	hsa-miR-3176	CLIP-seq
MIRT1968303	hsa-miR-3189-3p	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT1968304	hsa-miR-3922-3p	CLIP-seq
MIRT904706	hsa-miR-106a	CLIP-seq
MIRT904707	hsa-miR-106b	CLIP-seq
MIRT1968305	hsa-miR-1183	CLIP-seq
MIRT904708	hsa-miR-1288	CLIP-seq
MIRT904709	hsa-miR-17	CLIP-seq
MIRT904711	hsa-miR-20a	CLIP-seq
MIRT904712	hsa-miR-20b	CLIP-seq
MIRT904714	hsa-miR-298	CLIP-seq
MIRT1968306	hsa-miR-302a	CLIP-seq
MIRT1968307	hsa-miR-302b	CLIP-seq
MIRT1968308	hsa-miR-302c	CLIP-seq
MIRT1968309	hsa-miR-302d	CLIP-seq
MIRT1968310	hsa-miR-302e	CLIP-seq
MIRT1968311	hsa-miR-3150b-3p	CLIP-seq
MIRT904715	hsa-miR-3158-5p	CLIP-seq
MIRT904716	hsa-miR-3169	CLIP-seq
MIRT904717	hsa-miR-3609	CLIP-seq
MIRT1968312	hsa-miR-372	CLIP-seq
MIRT1968313	hsa-miR-373	CLIP-seq
MIRT904720	hsa-miR-4418	CLIP-seq
MIRT1968314	hsa-miR-4689	CLIP-seq
MIRT1968315	hsa-miR-4695-5p	CLIP-seq
MIRT1968316	hsa-miR-4710	CLIP-seq
MIRT1968317	hsa-miR-4784	CLIP-seq
MIRT904722	hsa-miR-4796-3p	CLIP-seq
MIRT904723	hsa-miR-509-3-5p	CLIP-seq
MIRT904724	hsa-miR-509-5p	CLIP-seq
MIRT904725	hsa-miR-519d	CLIP-seq
MIRT1968318	hsa-miR-520a-3p	CLIP-seq
MIRT1968319	hsa-miR-520b	CLIP-seq
MIRT1968320	hsa-miR-520c-3p	CLIP-seq
MIRT1968321	hsa-miR-520d-3p	CLIP-seq
MIRT1968322	hsa-miR-520e	CLIP-seq
MIRT904726	hsa-miR-548ah	CLIP-seq
MIRT904727	hsa-miR-93	CLIP-seq
MIRT904706	hsa-miR-106a	CLIP-seq
MIRT904707	hsa-miR-106b	CLIP-seq
MIRT904708	hsa-miR-1288	CLIP-seq
MIRT904709	hsa-miR-17	CLIP-seq
MIRT904711	hsa-miR-20a	CLIP-seq
MIRT904712	hsa-miR-20b	CLIP-seq
MIRT904714	hsa-miR-298	CLIP-seq
MIRT2204133	hsa-miR-299-3p	CLIP-seq
MIRT1968306	hsa-miR-302a	CLIP-seq
MIRT1968307	hsa-miR-302b	CLIP-seq
MIRT1968308	hsa-miR-302c	CLIP-seq
MIRT1968309	hsa-miR-302d	CLIP-seq
MIRT1968310	hsa-miR-302e	CLIP-seq
MIRT904715	hsa-miR-3158-5p	CLIP-seq
MIRT904716	hsa-miR-3169	CLIP-seq
MIRT2204134	hsa-miR-34b	CLIP-seq
MIRT904717	hsa-miR-3609	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT1968312	hsa-miR-372	CLIP-seq
MIRT1968313	hsa-miR-373	CLIP-seq
MIRT904720	hsa-miR-4418	CLIP-seq
MIRT2204135	hsa-miR-4648	CLIP-seq
MIRT2204136	hsa-miR-4654	CLIP-seq
MIRT904740	hsa-miR-4728-5p	CLIP-seq
MIRT2204137	hsa-miR-4769-5p	CLIP-seq
MIRT904722	hsa-miR-4796-3p	CLIP-seq
MIRT904723	hsa-miR-509-3-5p	CLIP-seq
MIRT904724	hsa-miR-509-5p	CLIP-seq
MIRT904725	hsa-miR-519d	CLIP-seq
MIRT1968318	hsa-miR-520a-3p	CLIP-seq
MIRT1968319	hsa-miR-520b	CLIP-seq
MIRT1968320	hsa-miR-520c-3p	CLIP-seq
MIRT1968321	hsa-miR-520d-3p	CLIP-seq
MIRT1968322	hsa-miR-520e	CLIP-seq
MIRT904726	hsa-miR-548ah	CLIP-seq
MIRT904727	hsa-miR-93	CLIP-seq
MIRT1968305	hsa-miR-1183	CLIP-seq
MIRT904729	hsa-miR-2392	CLIP-seq
MIRT2386379	hsa-miR-3064-5p	CLIP-seq
MIRT2386380	hsa-miR-3117-5p	CLIP-seq
MIRT2386381	hsa-miR-3137	CLIP-seq
MIRT1968311	hsa-miR-3150b-3p	CLIP-seq
MIRT2386382	hsa-miR-3151	CLIP-seq
MIRT904732	hsa-miR-3192	CLIP-seq
MIRT904733	hsa-miR-3605-5p	CLIP-seq
MIRT2386383	hsa-miR-3652	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT904736	hsa-miR-3689d	CLIP-seq
MIRT2386384	hsa-miR-4430	CLIP-seq
MIRT2386385	hsa-miR-4447	CLIP-seq
MIRT2386386	hsa-miR-4472	CLIP-seq
MIRT2386387	hsa-miR-4505	CLIP-seq
MIRT904738	hsa-miR-4534	CLIP-seq
MIRT1968314	hsa-miR-4689	CLIP-seq
MIRT1968315	hsa-miR-4695-5p	CLIP-seq
MIRT1968316	hsa-miR-4710	CLIP-seq
MIRT904740	hsa-miR-4728-5p	CLIP-seq
MIRT1968317	hsa-miR-4784	CLIP-seq
MIRT904741	hsa-miR-4802-5p	CLIP-seq
MIRT2386388	hsa-miR-491-5p	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT2386389	hsa-miR-593	CLIP-seq
MIRT1968305	hsa-miR-1183	CLIP-seq
MIRT2507583	hsa-miR-1225-5p	CLIP-seq
MIRT2507584	hsa-miR-1250	CLIP-seq
MIRT2507585	hsa-miR-1263	CLIP-seq
MIRT2507586	hsa-miR-1273f	CLIP-seq
MIRT2507587	hsa-miR-129-3p	CLIP-seq
MIRT2507588	hsa-miR-143	CLIP-seq
MIRT904710	hsa-miR-1915	CLIP-seq
MIRT2507589	hsa-miR-2115	CLIP-seq
MIRT904713	hsa-miR-2355-5p	CLIP-seq
MIRT904729	hsa-miR-2392	CLIP-seq
MIRT2507590	hsa-miR-27a	CLIP-seq
MIRT2507591	hsa-miR-27b	CLIP-seq
MIRT2507592	hsa-miR-2964a-5p	CLIP-seq
MIRT2386379	hsa-miR-3064-5p	CLIP-seq
MIRT2386380	hsa-miR-3117-5p	CLIP-seq
MIRT2507593	hsa-miR-3127-3p	CLIP-seq
MIRT2507594	hsa-miR-3132	CLIP-seq
MIRT2386381	hsa-miR-3137	CLIP-seq
MIRT1968311	hsa-miR-3150b-3p	CLIP-seq
MIRT2386382	hsa-miR-3151	CLIP-seq
MIRT1968302	hsa-miR-3176	CLIP-seq
MIRT2507595	hsa-miR-3184	CLIP-seq
MIRT904732	hsa-miR-3192	CLIP-seq
MIRT2507596	hsa-miR-324-5p	CLIP-seq
MIRT2507597	hsa-miR-346	CLIP-seq
MIRT904733	hsa-miR-3605-5p	CLIP-seq
MIRT2507598	hsa-miR-3622a-3p	CLIP-seq
MIRT2507599	hsa-miR-3622b-3p	CLIP-seq
MIRT2386383	hsa-miR-3652	CLIP-seq
MIRT2507600	hsa-miR-3663-5p	CLIP-seq
MIRT904734	hsa-miR-3689a-3p	CLIP-seq
MIRT904735	hsa-miR-3689c	CLIP-seq
MIRT904736	hsa-miR-3689d	CLIP-seq
MIRT904718	hsa-miR-3918	CLIP-seq
MIRT1968304	hsa-miR-3922-3p	CLIP-seq
MIRT2507601	hsa-miR-3937	CLIP-seq
MIRT2507602	hsa-miR-3943	CLIP-seq
MIRT2507603	hsa-miR-423-5p	CLIP-seq
MIRT2507604	hsa-miR-4254	CLIP-seq
MIRT2507605	hsa-miR-4267	CLIP-seq
MIRT2507606	hsa-miR-4276	CLIP-seq
MIRT904719	hsa-miR-4297	CLIP-seq
MIRT2507607	hsa-miR-4313	CLIP-seq
MIRT2507608	hsa-miR-4318	CLIP-seq
MIRT2507609	hsa-miR-4321	CLIP-seq
MIRT2507610	hsa-miR-4329	CLIP-seq
MIRT2386384	hsa-miR-4430	CLIP-seq
MIRT2386385	hsa-miR-4447	CLIP-seq
MIRT2507611	hsa-miR-4459	CLIP-seq
MIRT2386386	hsa-miR-4472	CLIP-seq
MIRT2386387	hsa-miR-4505	CLIP-seq
MIRT2507612	hsa-miR-4527	CLIP-seq
MIRT904738	hsa-miR-4534	CLIP-seq
MIRT2507613	hsa-miR-4536	CLIP-seq
MIRT2507614	hsa-miR-4645-5p	CLIP-seq
MIRT2507615	hsa-miR-4663	CLIP-seq
MIRT2507616	hsa-miR-4668-5p	CLIP-seq
MIRT2507617	hsa-miR-4673	CLIP-seq
MIRT904721	hsa-miR-4685-5p	CLIP-seq
MIRT2507618	hsa-miR-4687-5p	CLIP-seq
MIRT1968314	hsa-miR-4689	CLIP-seq
MIRT1968315	hsa-miR-4695-5p	CLIP-seq
MIRT2507619	hsa-miR-4708-5p	CLIP-seq
MIRT1968316	hsa-miR-4710	CLIP-seq
MIRT2507620	hsa-miR-4724-3p	CLIP-seq
MIRT2507621	hsa-miR-4725-5p	CLIP-seq
MIRT2507622	hsa-miR-4728-3p	CLIP-seq
MIRT904740	hsa-miR-4728-5p	CLIP-seq
MIRT2507623	hsa-miR-4746-3p	CLIP-seq
MIRT2507624	hsa-miR-4757-5p	CLIP-seq
MIRT2507625	hsa-miR-4770	CLIP-seq
MIRT1968317	hsa-miR-4784	CLIP-seq
MIRT2507626	hsa-miR-4786-3p	CLIP-seq
MIRT904741	hsa-miR-4802-5p	CLIP-seq
MIRT2386388	hsa-miR-491-5p	CLIP-seq
MIRT2507627	hsa-miR-504	CLIP-seq
MIRT2507628	hsa-miR-512-3p	CLIP-seq
MIRT2507629	hsa-miR-513a-5p	CLIP-seq
MIRT2507630	hsa-miR-619	CLIP-seq
MIRT2507631	hsa-miR-665	CLIP-seq
MIRT2507632	hsa-miR-885-3p	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003093	Process	Regulation of glomerular filtration	IEA
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	NAS	10224093
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	IDA	29162887
GO:0005925	Component	Focal adhesion	IEA
GO:0010812	Process	Negative regulation of cell-substrate adhesion	IDA	29162887
GO:0015629	Component	Actin cytoskeleton	NAS	10224093
GO:0016020	Component	Membrane	NAS	10224093
GO:0017166	Function	Vinculin binding	IPI	29162887
GO:0030036	Process	Actin cytoskeleton organization	NAS	10224093
GO:0032956	Process	Regulation of actin cytoskeleton organization	IDA	29162887
GO:0048041	Process	Focal adhesion assembly	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0051497	Process	Negative regulation of stress fiber assembly	IEA
GO:0080135	Process	Regulation of cellular response to stress	IDA	29162887
GO:1904950	Process	Negative regulation of establishment of protein localization	IDA	29162887
GO:1904951	Process	Positive regulation of establishment of protein localization	IDA	29162887
GO:1990147	Function	Talin binding	IDA	29162887

MIM	HGNC	e!Ensembl
605002	2256	ENSG00000103647

Q9UQ03

Protein name

Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96)

Protein function

May play a role in the reorganization of neuronal actin structure.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08953	DUF1899	10 → 75	Domain of unknown function (DUF1899)	Domain
PF00400	WD40	78 → 116	WD domain, G-beta repeat	Repeat
PF00400	WD40	170 → 208	WD domain, G-beta repeat	Repeat
PF16300	WD40_4	350 → 392		Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in brain.

Sequence

MTVTKMSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESA
GGGSFLVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEG
GLKRNMTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMIDCHT
DVILCMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNHRVNRVVFLGNMKRLLTT
GVSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEI
STEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRR
SDSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFKAPIKEKKSVV
VNGIDLLENVPPRTENELLRMFFRQQDEIRRLKEELAQKDIRIRQLQLELKNLRNSPKNC

Sequence length

480

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Ciliopathies	Ciliopathy	Pubtator	28800606	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	31221975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	31221975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	31221975	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	31221975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	31221975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	31221975	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CORO2B (coronin 2B)