Gene Gene information from NCBI Gene database.
Entrez ID 10380
Gene name 3'(2'), 5'-bisphosphate nucleotidase 1
Gene symbol BPNT1
Synonyms (NCBI Gene)
HEL20HsPIPPIP
Chromosome 1
Chromosome location 1q41
Summary BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human pro
miRNA miRNA information provided by mirtarbase database.
478
miRTarBase ID miRNA Experiments Reference
MIRT694561 hsa-miR-5197-5p HITS-CLIP 23313552
MIRT694560 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT694559 hsa-miR-6893-5p HITS-CLIP 23313552
MIRT694558 hsa-miR-940 HITS-CLIP 23313552
MIRT694557 hsa-miR-3929 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0004441 Function Inositol-1,4-bisphosphate 1-phosphatase activity IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005829 Component Cytosol TAS
GO:0006139 Process Nucleobase-containing compound metabolic process TAS 10224133
GO:0007399 Process Nervous system development TAS 10224133
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604053 1096 ENSG00000162813
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95861
Protein name 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (HsPIP) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)
Protein function Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenos
PDB 2WEF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00459 Inositol_P 8 303 Inositol monophosphatase family Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle. {ECO:0000269|PubMed:10224133}.
Sequence
Sequence length 308
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Sulfur metabolism
Metabolic pathways
  Cytosolic sulfonation of small molecules
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 15182429, 19620839, 22963903, 28693610
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19620839, 30628926
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 15182429
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 27153935
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 40471493 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Andersen Syndrome Andersen Syndrome BEFREE 17568571
★☆☆☆☆
Found in Text Mining only
Aneuploidy Aneuploidy Pubtator 24862759 Inhibit
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28208754
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 18980958
★☆☆☆☆
Found in Text Mining only
Arthrogryposis Arthrogryposis multiplex congenita BEFREE 17701898
★☆☆☆☆
Found in Text Mining only