CCL26 (C-C motif chemokine ligand 26)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 10344
Gene name C-C motif chemokine ligand 26
Gene symbol CCL26
Synonyms (NCBI Gene)
IMACMIP-4aMIP-4alphaSCYA26TSC-1
Chromosome 7
Chromosome location 7q11.23
Summary This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cy
miRNA miRNA information provided by mirtarbase database.
9
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (9)
miRTarBase ID miRNA Experiments Reference
MIRT006454 hsa-miR-25-3p Luciferase reporter assayqRT-PCRWestern blot 22431589
MIRT006454 hsa-miR-25-3p Luciferase reporter assayqRT-PCRWestern blot 22431589
MIRT006454 hsa-miR-25-3p Luciferase reporter assayqRT-PCRWestern blot 22431589
MIRT006454 hsa-miR-25-3p Luciferase reporter assayqRT-PCRWestern blot 22431589
MIRT006454 hsa-miR-25-3p Luciferase reporter assayqRT-PCRWestern blot 22431589
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
STAT6 Activation 11544308;15589317
STAT6 Unknown 18342537
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 19525930
GO:0002548 Process Monocyte chemotaxis IDA 10373330
GO:0005125 Function Cytokine activity IEA
GO:0005515 Function Protein binding IPI 28381538, 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604697 10625 ENSG00000006606
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y258
Protein name C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1)
Protein function Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). Also acts a
PDB 1G2S , 1G2T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 31 → 88 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed at low levels in various tissues including heart and ovary. {ECO:0000269|PubMed:10373330, ECO:0000269|PubMed:10488147}.
Sequence
Sequence length 94
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (80)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 15580493, 31403761
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 22801723 Stimulate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Alzheimer Disease Alzheimer disease Pubtator 29070909 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Alzheimer disease, familial, type 3 Alzheimer disease BEFREE 20236835
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 11415932, 14698143, 15207712, 15784470, 15863444, 16391516, 19203252, 22846146, 23402658, 25091434, 28089872, 30382768, 30468398
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 19203252, 21764283, 23015684, 27845745, 30197185, 32460303, 34106513, 37241840 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autoimmune Diseases Autoimmune Diseases BEFREE 15784470
★★★★★
★☆☆☆☆
Found in Text Mining only
Blister Blister Pubtator 27868136 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Bullous pemphigoid Bullous Pemphigoid BEFREE 27868136
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 23684136 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only