Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10316
Gene name	Neuromedin U receptor 1
Gene symbol	NMUR1
Synonyms (NCBI Gene)	(FM-3)FM-3FM3GPC-RGPR66NMU1R
Chromosome	2
Chromosome location	2q37.1

203

Show/Hide all (203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT664271	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT664270	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT664269	hsa-miR-940	HITS-CLIP	23824327
MIRT664268	hsa-miR-3929	HITS-CLIP	23824327
MIRT664267	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664266	hsa-miR-4478	HITS-CLIP	23824327
MIRT664265	hsa-miR-4459	HITS-CLIP	23824327
MIRT664264	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT664263	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT664262	hsa-miR-1827	HITS-CLIP	23824327
MIRT664261	hsa-miR-6087	HITS-CLIP	23824327
MIRT664260	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664259	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664258	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT664257	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT664256	hsa-miR-25-5p	HITS-CLIP	23824327
MIRT664255	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT664254	hsa-miR-665	HITS-CLIP	23824327
MIRT664271	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT664270	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT664269	hsa-miR-940	HITS-CLIP	23824327
MIRT664268	hsa-miR-3929	HITS-CLIP	23824327
MIRT664267	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664266	hsa-miR-4478	HITS-CLIP	23824327
MIRT664265	hsa-miR-4459	HITS-CLIP	23824327
MIRT664264	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT664263	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT664262	hsa-miR-1827	HITS-CLIP	23824327
MIRT664261	hsa-miR-6087	HITS-CLIP	23824327
MIRT664260	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664259	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664258	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT664257	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT664256	hsa-miR-25-5p	HITS-CLIP	23824327
MIRT664255	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT664254	hsa-miR-665	HITS-CLIP	23824327
MIRT1188025	hsa-miR-1207-5p	CLIP-seq
MIRT1188026	hsa-miR-1273	CLIP-seq
MIRT1188027	hsa-miR-1273e	CLIP-seq
MIRT1188028	hsa-miR-1289	CLIP-seq
MIRT1188029	hsa-miR-1470	CLIP-seq
MIRT1188030	hsa-miR-151-3p	CLIP-seq
MIRT1188031	hsa-miR-1587	CLIP-seq
MIRT1188032	hsa-miR-184	CLIP-seq
MIRT1188033	hsa-miR-190	CLIP-seq
MIRT1188034	hsa-miR-190b	CLIP-seq
MIRT1188035	hsa-miR-1976	CLIP-seq
MIRT1188036	hsa-miR-2114	CLIP-seq
MIRT1188037	hsa-miR-2355-5p	CLIP-seq
MIRT1188038	hsa-miR-31	CLIP-seq
MIRT1188039	hsa-miR-3120-5p	CLIP-seq
MIRT1188040	hsa-miR-3128	CLIP-seq
MIRT1188041	hsa-miR-3151	CLIP-seq
MIRT1188042	hsa-miR-3161	CLIP-seq
MIRT1188043	hsa-miR-3170	CLIP-seq
MIRT1188044	hsa-miR-323-5p	CLIP-seq
MIRT1188045	hsa-miR-329	CLIP-seq
MIRT1188046	hsa-miR-335	CLIP-seq
MIRT1188047	hsa-miR-3529	CLIP-seq
MIRT1188048	hsa-miR-361-3p	CLIP-seq
MIRT1188049	hsa-miR-3622a-3p	CLIP-seq
MIRT1188050	hsa-miR-3622b-3p	CLIP-seq
MIRT1188051	hsa-miR-362-3p	CLIP-seq
MIRT1188052	hsa-miR-3664-5p	CLIP-seq
MIRT1188053	hsa-miR-3672	CLIP-seq
MIRT1188054	hsa-miR-3689d	CLIP-seq
MIRT1188055	hsa-miR-370	CLIP-seq
MIRT1188056	hsa-miR-379	CLIP-seq
MIRT1188057	hsa-miR-3926	CLIP-seq
MIRT1188058	hsa-miR-3927	CLIP-seq
MIRT1188059	hsa-miR-3938	CLIP-seq
MIRT1188060	hsa-miR-3941	CLIP-seq
MIRT1188061	hsa-miR-4270	CLIP-seq
MIRT1188062	hsa-miR-4283	CLIP-seq
MIRT1188063	hsa-miR-4284	CLIP-seq
MIRT1188064	hsa-miR-4292	CLIP-seq
MIRT1188065	hsa-miR-4308	CLIP-seq
MIRT1188066	hsa-miR-4330	CLIP-seq
MIRT1188067	hsa-miR-4417	CLIP-seq
MIRT1188068	hsa-miR-4437	CLIP-seq
MIRT1188069	hsa-miR-4441	CLIP-seq
MIRT1188070	hsa-miR-4446-5p	CLIP-seq
MIRT1188071	hsa-miR-4463	CLIP-seq
MIRT1188072	hsa-miR-4489	CLIP-seq
MIRT1188073	hsa-miR-4492	CLIP-seq
MIRT1188074	hsa-miR-4498	CLIP-seq
MIRT1188075	hsa-miR-4499	CLIP-seq
MIRT1188076	hsa-miR-4522	CLIP-seq
MIRT1188077	hsa-miR-4656	CLIP-seq
MIRT1188078	hsa-miR-466	CLIP-seq
MIRT1188079	hsa-miR-4667-3p	CLIP-seq
MIRT1188080	hsa-miR-4672	CLIP-seq
MIRT1188081	hsa-miR-4675	CLIP-seq
MIRT1188082	hsa-miR-4684-5p	CLIP-seq
MIRT1188083	hsa-miR-4713-3p	CLIP-seq
MIRT1188084	hsa-miR-4731-5p	CLIP-seq
MIRT1188085	hsa-miR-4736	CLIP-seq
MIRT1188086	hsa-miR-4741	CLIP-seq
MIRT1188087	hsa-miR-4755-5p	CLIP-seq
MIRT1188088	hsa-miR-4761-5p	CLIP-seq
MIRT1188089	hsa-miR-4763-3p	CLIP-seq
MIRT1188090	hsa-miR-4768-3p	CLIP-seq
MIRT1188091	hsa-miR-4786-5p	CLIP-seq
MIRT1188092	hsa-miR-4795-5p	CLIP-seq
MIRT1188093	hsa-miR-4797-5p	CLIP-seq
MIRT1188094	hsa-miR-541	CLIP-seq
MIRT1188095	hsa-miR-548aa	CLIP-seq
MIRT1188096	hsa-miR-548m	CLIP-seq
MIRT1188097	hsa-miR-548s	CLIP-seq
MIRT1188098	hsa-miR-603	CLIP-seq
MIRT1188099	hsa-miR-624	CLIP-seq
MIRT1188100	hsa-miR-654-5p	CLIP-seq
MIRT1188101	hsa-miR-658	CLIP-seq
MIRT1188102	hsa-miR-670	CLIP-seq
MIRT1188103	hsa-miR-759	CLIP-seq
MIRT1188104	hsa-miR-762	CLIP-seq
MIRT1188105	hsa-miR-769-5p	CLIP-seq
MIRT1188106	hsa-miR-876-3p	CLIP-seq
MIRT1551786	hsa-miR-4738-3p	CLIP-seq
MIRT1188082	hsa-miR-4684-5p	CLIP-seq
MIRT1922286	hsa-miR-548c-3p	CLIP-seq
MIRT2054517	hsa-miR-1184	CLIP-seq
MIRT1188036	hsa-miR-2114	CLIP-seq
MIRT2054518	hsa-miR-214	CLIP-seq
MIRT2054519	hsa-miR-3619-5p	CLIP-seq
MIRT1188049	hsa-miR-3622a-3p	CLIP-seq
MIRT1188050	hsa-miR-3622b-3p	CLIP-seq
MIRT1188061	hsa-miR-4270	CLIP-seq
MIRT1188063	hsa-miR-4284	CLIP-seq
MIRT1188069	hsa-miR-4441	CLIP-seq
MIRT1188090	hsa-miR-4768-3p	CLIP-seq
MIRT1188101	hsa-miR-658	CLIP-seq
MIRT2054520	hsa-miR-761	CLIP-seq
MIRT1188106	hsa-miR-876-3p	CLIP-seq
MIRT2283571	hsa-miR-1251	CLIP-seq
MIRT1188026	hsa-miR-1273	CLIP-seq
MIRT1188036	hsa-miR-2114	CLIP-seq
MIRT2283572	hsa-miR-24	CLIP-seq
MIRT2283573	hsa-miR-3150a-3p	CLIP-seq
MIRT2283574	hsa-miR-3175	CLIP-seq
MIRT1188046	hsa-miR-335	CLIP-seq
MIRT2283575	hsa-miR-3616-3p	CLIP-seq
MIRT1188049	hsa-miR-3622a-3p	CLIP-seq
MIRT1188050	hsa-miR-3622b-3p	CLIP-seq
MIRT1188053	hsa-miR-3672	CLIP-seq
MIRT1188057	hsa-miR-3926	CLIP-seq
MIRT2283576	hsa-miR-4252	CLIP-seq
MIRT1188063	hsa-miR-4284	CLIP-seq
MIRT2283577	hsa-miR-4293	CLIP-seq
MIRT2283578	hsa-miR-4455	CLIP-seq
MIRT2283579	hsa-miR-4486	CLIP-seq
MIRT2283580	hsa-miR-4649-5p	CLIP-seq
MIRT2283581	hsa-miR-4728-5p	CLIP-seq
MIRT2283582	hsa-miR-4743	CLIP-seq
MIRT2283583	hsa-miR-4761-3p	CLIP-seq
MIRT1188091	hsa-miR-4786-5p	CLIP-seq
MIRT2283584	hsa-miR-4793-3p	CLIP-seq
MIRT2283585	hsa-miR-509-3p	CLIP-seq
MIRT2283586	hsa-miR-544b	CLIP-seq
MIRT1188097	hsa-miR-548s	CLIP-seq
MIRT2283587	hsa-miR-596	CLIP-seq
MIRT2283588	hsa-miR-661	CLIP-seq
MIRT1188105	hsa-miR-769-5p	CLIP-seq
MIRT2283589	hsa-miR-939	CLIP-seq
MIRT2283571	hsa-miR-1251	CLIP-seq
MIRT1188026	hsa-miR-1273	CLIP-seq
MIRT1188036	hsa-miR-2114	CLIP-seq
MIRT1188039	hsa-miR-3120-5p	CLIP-seq
MIRT1188049	hsa-miR-3622a-3p	CLIP-seq
MIRT1188050	hsa-miR-3622b-3p	CLIP-seq
MIRT1188052	hsa-miR-3664-5p	CLIP-seq
MIRT1188053	hsa-miR-3672	CLIP-seq
MIRT2283576	hsa-miR-4252	CLIP-seq
MIRT2283577	hsa-miR-4293	CLIP-seq
MIRT1188066	hsa-miR-4330	CLIP-seq
MIRT2283579	hsa-miR-4486	CLIP-seq
MIRT1188076	hsa-miR-4522	CLIP-seq
MIRT2283580	hsa-miR-4649-5p	CLIP-seq
MIRT1188082	hsa-miR-4684-5p	CLIP-seq
MIRT2283584	hsa-miR-4793-3p	CLIP-seq
MIRT1188093	hsa-miR-4797-5p	CLIP-seq
MIRT1922286	hsa-miR-548c-3p	CLIP-seq
MIRT2283587	hsa-miR-596	CLIP-seq
MIRT2283588	hsa-miR-661	CLIP-seq
MIRT1188103	hsa-miR-759	CLIP-seq
MIRT2283571	hsa-miR-1251	CLIP-seq
MIRT1188026	hsa-miR-1273	CLIP-seq
MIRT1188039	hsa-miR-3120-5p	CLIP-seq
MIRT1188052	hsa-miR-3664-5p	CLIP-seq
MIRT1188053	hsa-miR-3672	CLIP-seq
MIRT2283576	hsa-miR-4252	CLIP-seq
MIRT2283577	hsa-miR-4293	CLIP-seq
MIRT1188066	hsa-miR-4330	CLIP-seq
MIRT2283579	hsa-miR-4486	CLIP-seq
MIRT1188076	hsa-miR-4522	CLIP-seq
MIRT2283580	hsa-miR-4649-5p	CLIP-seq
MIRT1188082	hsa-miR-4684-5p	CLIP-seq
MIRT2283584	hsa-miR-4793-3p	CLIP-seq
MIRT1188093	hsa-miR-4797-5p	CLIP-seq
MIRT1922286	hsa-miR-548c-3p	CLIP-seq
MIRT2283587	hsa-miR-596	CLIP-seq
MIRT2283588	hsa-miR-661	CLIP-seq
MIRT1188103	hsa-miR-759	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001607	Function	Neuromedin U receptor activity	IDA	10894543, 10899166, 11027493
GO:0001607	Function	Neuromedin U receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9782091, 10899166
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9782091
GO:0005929	Component	Cilium	IEA
GO:0006821	Process	Chloride transport	IDA	10899166
GO:0006821	Process	Chloride transport	IEA
GO:0006939	Process	Smooth muscle contraction	IEP	10899166
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9782091
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	10899166
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	TAS	10899166
GO:0008188	Function	Neuropeptide receptor activity	IBA
GO:0008188	Function	Neuropeptide receptor activity	IEA
GO:0008188	Function	Neuropeptide receptor activity	TAS	10811630
GO:0016020	Component	Membrane	IDA	10899166
GO:0016020	Component	Membrane	IEA
GO:0019722	Process	Calcium-mediated signaling	IDA	10894543, 11027493
GO:0042924	Function	Neuromedin U binding	IDA	10894543, 11027493
GO:0042924	Function	Neuromedin U binding	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IDA	10899166

MIM	HGNC	e!Ensembl
604153	4518	ENSG00000171596

Q9HB89

Protein name

Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)

Protein function

Receptor for the neuromedin-U and neuromedin-S neuropeptides.

PDB

7W53 , 7W56

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	77 → 356	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those

Sequence

MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELF
MPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYE
MWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRR
VLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFF
CLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLF
VLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMS
SRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQ
QETDPS

Sequence length

426

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORNEAL ASTIGMATISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	Pubtator	32460303	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	32291385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33066779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36482448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	21791076	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	15187020	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	15187020	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Moyamoya disease	Pubtator	38402855	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36232539	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Oropharyngeal neoplasm	Pubtator	31974445	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis Knee	Osteoarthritis	Pubtator	36232539	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29115427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	40435035	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis	Rhinitis	Pubtator	32460303	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	31974445	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NMUR1 (neuromedin U receptor 1)