Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10284
Gene name	Sin3A associated protein 18
Gene symbol	SAP18
Synonyms (NCBI Gene)	2HOR0202SAP18P
Chromosome	13
Chromosome location	13q12.11
Summary	Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048161	hsa-miR-196a-5p	CLASH	23622248
MIRT043131	hsa-miR-324-5p	CLASH	23622248
MIRT043002	hsa-miR-324-3p	CLASH	23622248
MIRT041858	hsa-miR-484	CLASH	23622248
MIRT037310	hsa-miR-877-5p	CLASH	23622248
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT468806	hsa-miR-4307	PAR-CLIP	20371350
MIRT068047	hsa-miR-3185	PAR-CLIP	20371350
MIRT068046	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT068045	hsa-miR-567	PAR-CLIP	20371350
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT468806	hsa-miR-4307	PAR-CLIP	20371350
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT068047	hsa-miR-3185	PAR-CLIP	20371350
MIRT068046	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT068045	hsa-miR-567	PAR-CLIP	20371350
MIRT468807	hsa-miR-34a-3p	PAR-CLIP	23446348
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	23446348
MIRT468806	hsa-miR-4307	PAR-CLIP	23446348
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	23446348
MIRT068047	hsa-miR-3185	PAR-CLIP	23446348
MIRT068046	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	23446348
MIRT068045	hsa-miR-567	PAR-CLIP	23446348
MIRT468807	hsa-miR-34a-3p	PAR-CLIP	23592263
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT468806	hsa-miR-4307	PAR-CLIP	23592263
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT068047	hsa-miR-3185	PAR-CLIP	23592263
MIRT068046	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT068045	hsa-miR-567	PAR-CLIP	23592263
MIRT439710	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439710	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT468806	hsa-miR-4307	PAR-CLIP	20371350
MIRT068047	hsa-miR-3185	PAR-CLIP	20371350
MIRT068046	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT068045	hsa-miR-567	PAR-CLIP	20371350
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT468806	hsa-miR-4307	PAR-CLIP	20371350
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT068047	hsa-miR-3185	PAR-CLIP	20371350
MIRT068046	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT068045	hsa-miR-567	PAR-CLIP	20371350
MIRT468807	hsa-miR-34a-3p	PAR-CLIP	23446348
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	23446348
MIRT468806	hsa-miR-4307	PAR-CLIP	23446348
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	23446348
MIRT068047	hsa-miR-3185	PAR-CLIP	23446348
MIRT068046	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	23446348
MIRT068045	hsa-miR-567	PAR-CLIP	23446348
MIRT468807	hsa-miR-34a-3p	PAR-CLIP	23592263
MIRT068048	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT468806	hsa-miR-4307	PAR-CLIP	23592263
MIRT468805	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT068047	hsa-miR-3185	PAR-CLIP	23592263
MIRT068046	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT068050	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT068049	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT068045	hsa-miR-567	PAR-CLIP	23592263
MIRT1325730	hsa-miR-101	CLIP-seq
MIRT1325731	hsa-miR-1183	CLIP-seq
MIRT1325732	hsa-miR-1238	CLIP-seq
MIRT1325733	hsa-miR-1279	CLIP-seq
MIRT1325734	hsa-miR-1295	CLIP-seq
MIRT1325735	hsa-miR-1305	CLIP-seq
MIRT1325736	hsa-miR-132	CLIP-seq
MIRT1325737	hsa-miR-1322	CLIP-seq
MIRT1325738	hsa-miR-140-3p	CLIP-seq
MIRT1325739	hsa-miR-1468	CLIP-seq
MIRT1325740	hsa-miR-194	CLIP-seq
MIRT1325741	hsa-miR-212	CLIP-seq
MIRT1325742	hsa-miR-296-3p	CLIP-seq
MIRT1325743	hsa-miR-29a	CLIP-seq
MIRT1325744	hsa-miR-29b	CLIP-seq
MIRT1325745	hsa-miR-29c	CLIP-seq
MIRT1325746	hsa-miR-3065-5p	CLIP-seq
MIRT1325747	hsa-miR-3121-3p	CLIP-seq
MIRT1325748	hsa-miR-3148	CLIP-seq
MIRT1325749	hsa-miR-3154	CLIP-seq
MIRT1325750	hsa-miR-3155	CLIP-seq
MIRT1325751	hsa-miR-3155b	CLIP-seq
MIRT1325752	hsa-miR-3158-3p	CLIP-seq
MIRT1325753	hsa-miR-3170	CLIP-seq
MIRT1325754	hsa-miR-329	CLIP-seq
MIRT1325755	hsa-miR-337-3p	CLIP-seq
MIRT1325756	hsa-miR-338-5p	CLIP-seq
MIRT1325757	hsa-miR-3605-3p	CLIP-seq
MIRT1325758	hsa-miR-362-3p	CLIP-seq
MIRT1325759	hsa-miR-3679-3p	CLIP-seq
MIRT1325760	hsa-miR-3685	CLIP-seq
MIRT1325761	hsa-miR-374a	CLIP-seq
MIRT1325762	hsa-miR-374b	CLIP-seq
MIRT1325763	hsa-miR-3920	CLIP-seq
MIRT1325764	hsa-miR-3929	CLIP-seq
MIRT1325765	hsa-miR-3941	CLIP-seq
MIRT1325766	hsa-miR-421	CLIP-seq
MIRT1325767	hsa-miR-4260	CLIP-seq
MIRT1325768	hsa-miR-4272	CLIP-seq
MIRT1325769	hsa-miR-4328	CLIP-seq
MIRT1325770	hsa-miR-4419b	CLIP-seq
MIRT1325771	hsa-miR-4464	CLIP-seq
MIRT1325772	hsa-miR-4478	CLIP-seq
MIRT1325773	hsa-miR-4484	CLIP-seq
MIRT1325774	hsa-miR-4509	CLIP-seq
MIRT1325775	hsa-miR-4528	CLIP-seq
MIRT1325776	hsa-miR-4639-5p	CLIP-seq
MIRT1325777	hsa-miR-4659a-3p	CLIP-seq
MIRT1325778	hsa-miR-4659b-3p	CLIP-seq
MIRT1325779	hsa-miR-466	CLIP-seq
MIRT1325780	hsa-miR-4666-3p	CLIP-seq
MIRT1325781	hsa-miR-4672	CLIP-seq
MIRT1325782	hsa-miR-4748	CLIP-seq
MIRT1325783	hsa-miR-4762-5p	CLIP-seq
MIRT1325784	hsa-miR-4764-3p	CLIP-seq
MIRT1325785	hsa-miR-4789-3p	CLIP-seq
MIRT1325786	hsa-miR-485-3p	CLIP-seq
MIRT1325787	hsa-miR-487a	CLIP-seq
MIRT1325788	hsa-miR-494	CLIP-seq
MIRT1325789	hsa-miR-495	CLIP-seq
MIRT1325790	hsa-miR-520d-5p	CLIP-seq
MIRT1325791	hsa-miR-524-5p	CLIP-seq
MIRT1325792	hsa-miR-548an	CLIP-seq
MIRT1325793	hsa-miR-548m	CLIP-seq
MIRT1325794	hsa-miR-582-5p	CLIP-seq
MIRT1325795	hsa-miR-586	CLIP-seq
MIRT1325796	hsa-miR-603	CLIP-seq
MIRT1325797	hsa-miR-622	CLIP-seq
MIRT1325798	hsa-miR-645	CLIP-seq
MIRT2096657	hsa-miR-10a	CLIP-seq
MIRT2096658	hsa-miR-10b	CLIP-seq
MIRT2096659	hsa-miR-1206	CLIP-seq
MIRT1325733	hsa-miR-1279	CLIP-seq
MIRT1325734	hsa-miR-1295	CLIP-seq
MIRT2096660	hsa-miR-136	CLIP-seq
MIRT2096661	hsa-miR-1470	CLIP-seq
MIRT2096662	hsa-miR-1915	CLIP-seq
MIRT2096663	hsa-miR-205	CLIP-seq
MIRT1325755	hsa-miR-337-3p	CLIP-seq
MIRT1325756	hsa-miR-338-5p	CLIP-seq
MIRT2096664	hsa-miR-377	CLIP-seq
MIRT1325765	hsa-miR-3941	CLIP-seq
MIRT2096665	hsa-miR-412	CLIP-seq
MIRT2096666	hsa-miR-4287	CLIP-seq
MIRT2096667	hsa-miR-4469	CLIP-seq
MIRT2096668	hsa-miR-452	CLIP-seq
MIRT2096669	hsa-miR-4650-5p	CLIP-seq
MIRT2096670	hsa-miR-4655-3p	CLIP-seq
MIRT1325779	hsa-miR-466	CLIP-seq
MIRT2096671	hsa-miR-4667-3p	CLIP-seq
MIRT1325781	hsa-miR-4672	CLIP-seq
MIRT2096672	hsa-miR-4676-3p	CLIP-seq
MIRT2096673	hsa-miR-4685-3p	CLIP-seq
MIRT2096674	hsa-miR-4691-5p	CLIP-seq
MIRT2096675	hsa-miR-4713-5p	CLIP-seq
MIRT2096676	hsa-miR-4726-3p	CLIP-seq
MIRT1325797	hsa-miR-622	CLIP-seq
MIRT2096677	hsa-miR-760	CLIP-seq
MIRT2096678	hsa-miR-767-5p	CLIP-seq
MIRT2096679	hsa-miR-885-5p	CLIP-seq
MIRT2096680	hsa-miR-942	CLIP-seq
MIRT1325730	hsa-miR-101	CLIP-seq
MIRT1325733	hsa-miR-1279	CLIP-seq
MIRT1325736	hsa-miR-132	CLIP-seq
MIRT2321035	hsa-miR-137	CLIP-seq
MIRT2321036	hsa-miR-138	CLIP-seq
MIRT1325741	hsa-miR-212	CLIP-seq
MIRT2321037	hsa-miR-2467-3p	CLIP-seq
MIRT1325742	hsa-miR-296-3p	CLIP-seq
MIRT1325747	hsa-miR-3121-3p	CLIP-seq
MIRT1325749	hsa-miR-3154	CLIP-seq
MIRT1325752	hsa-miR-3158-3p	CLIP-seq
MIRT2321038	hsa-miR-3678-3p	CLIP-seq
MIRT1325759	hsa-miR-3679-3p	CLIP-seq
MIRT1325760	hsa-miR-3685	CLIP-seq
MIRT1325765	hsa-miR-3941	CLIP-seq
MIRT2321039	hsa-miR-4274	CLIP-seq
MIRT1325769	hsa-miR-4328	CLIP-seq
MIRT2321040	hsa-miR-4436a	CLIP-seq
MIRT1325776	hsa-miR-4639-5p	CLIP-seq
MIRT1325777	hsa-miR-4659a-3p	CLIP-seq
MIRT1325778	hsa-miR-4659b-3p	CLIP-seq
MIRT1325779	hsa-miR-466	CLIP-seq
MIRT1325780	hsa-miR-4666-3p	CLIP-seq
MIRT1325781	hsa-miR-4672	CLIP-seq
MIRT1325786	hsa-miR-485-3p	CLIP-seq
MIRT1325788	hsa-miR-494	CLIP-seq
MIRT1325794	hsa-miR-582-5p	CLIP-seq
MIRT2321041	hsa-miR-590-3p	CLIP-seq
MIRT1325732	hsa-miR-1238	CLIP-seq
MIRT1325759	hsa-miR-3679-3p	CLIP-seq
MIRT2096660	hsa-miR-136	CLIP-seq
MIRT2096661	hsa-miR-1470	CLIP-seq
MIRT2096663	hsa-miR-205	CLIP-seq
MIRT2096665	hsa-miR-412	CLIP-seq
MIRT2096667	hsa-miR-4469	CLIP-seq
MIRT2096671	hsa-miR-4667-3p	CLIP-seq
MIRT2096674	hsa-miR-4691-5p	CLIP-seq
MIRT2617060	hsa-miR-1245b-3p	CLIP-seq
MIRT2096660	hsa-miR-136	CLIP-seq
MIRT2096661	hsa-miR-1470	CLIP-seq
MIRT2096663	hsa-miR-205	CLIP-seq
MIRT2617061	hsa-miR-2355-3p	CLIP-seq
MIRT2617062	hsa-miR-3189-3p	CLIP-seq
MIRT2617063	hsa-miR-383	CLIP-seq
MIRT2096665	hsa-miR-412	CLIP-seq
MIRT1325768	hsa-miR-4272	CLIP-seq
MIRT2096666	hsa-miR-4287	CLIP-seq
MIRT2617064	hsa-miR-4330	CLIP-seq
MIRT2096667	hsa-miR-4469	CLIP-seq
MIRT2096670	hsa-miR-4655-3p	CLIP-seq
MIRT2096671	hsa-miR-4667-3p	CLIP-seq
MIRT2096673	hsa-miR-4685-3p	CLIP-seq
MIRT2096674	hsa-miR-4691-5p	CLIP-seq
MIRT2096675	hsa-miR-4713-5p	CLIP-seq
MIRT2617065	hsa-miR-4714-3p	CLIP-seq
MIRT2617066	hsa-miR-676	CLIP-seq
MIRT2096677	hsa-miR-760	CLIP-seq
MIRT2096680	hsa-miR-942	CLIP-seq
MIRT1325737	hsa-miR-1322	CLIP-seq
MIRT2096660	hsa-miR-136	CLIP-seq
MIRT2096661	hsa-miR-1470	CLIP-seq
MIRT2096663	hsa-miR-205	CLIP-seq
MIRT1325747	hsa-miR-3121-3p	CLIP-seq
MIRT1325756	hsa-miR-338-5p	CLIP-seq
MIRT1325761	hsa-miR-374a	CLIP-seq
MIRT1325762	hsa-miR-374b	CLIP-seq
MIRT2096665	hsa-miR-412	CLIP-seq
MIRT2096667	hsa-miR-4469	CLIP-seq
MIRT1325773	hsa-miR-4484	CLIP-seq
MIRT1325775	hsa-miR-4528	CLIP-seq
MIRT1325780	hsa-miR-4666-3p	CLIP-seq
MIRT2096671	hsa-miR-4667-3p	CLIP-seq
MIRT2096674	hsa-miR-4691-5p	CLIP-seq
MIRT1325783	hsa-miR-4762-5p	CLIP-seq
MIRT1325784	hsa-miR-4764-3p	CLIP-seq
MIRT1325786	hsa-miR-485-3p	CLIP-seq
MIRT1325787	hsa-miR-487a	CLIP-seq
MIRT1325788	hsa-miR-494	CLIP-seq
MIRT1325792	hsa-miR-548an	CLIP-seq
MIRT1325795	hsa-miR-586	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	TAS	9150135
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	20966198
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IMP	22203037
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	9150135
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	9150135, 22365833, 22388736, 25416956, 32296183, 33961781, 35271311, 39522233
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9150135
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016607	Component	Nuclear speck	IDA	20966198
GO:0016607	Component	Nuclear speck	IEA
GO:0035145	Component	Exon-exon junction complex	IDA	16314458
GO:0043065	Process	Positive regulation of apoptotic process	IDA	12665594
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	12665594
GO:0061574	Component	ASAP complex	IDA	12665594

MIM	HGNC	e!Ensembl
602949	10530	ENSG00000150459

O00422

Protein name

Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)

Protein function

Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of

PDB

2HDE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06487	SAP18	19 → 137	Sin3 associated polypeptide p18 (SAP18)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYT
WMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSM
TLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY

Sequence length

153

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway		HDACs deacetylate histones

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	33633844	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anterior segment mesenchymal dysgenesis	Anterior segment mesenchymal dysgenesis	Pubtator	37239394	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35812454	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	33633844	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SAP18 (Sin3A associated protein 18)