Gene Gene information from NCBI Gene database.
Entrez ID 10261
Gene name Immunoglobulin superfamily member 6
Gene symbol IGSF6
Synonyms (NCBI Gene)
DORA
Chromosome 16
Chromosome location 16p12.2
miRNA miRNA information provided by mirtarbase database.
1020
miRTarBase ID miRNA Experiments Reference
MIRT028904 hsa-miR-26b-5p Microarray 19088304
MIRT628909 hsa-miR-15a-3p HITS-CLIP 23824327
MIRT628908 hsa-miR-205-3p HITS-CLIP 23824327
MIRT628907 hsa-miR-383-3p HITS-CLIP 23824327
MIRT629941 hsa-miR-4742-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity TAS 9809579
GO:0005886 Component Plasma membrane TAS 9809579
GO:0006955 Process Immune response TAS 9809579
GO:0007166 Process Cell surface receptor signaling pathway TAS 9809579
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606222 5953 ENSG00000140749
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95976
Protein name Immunoglobulin superfamily member 6 (IgSF6) (Protein DORA)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 35 142 Immunoglobulin V-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues. {ECO:0000269|PubMed:9809579}.
Sequence
MGTASRSNIARHLQTNLILFCVGAVGACTLSVTQPWYLEVDYTHEAVTIKCTFSATGCPS
EQPTCLWFRYGAHQPENLCLDGCKSEADKFTVREALKENQVSLTVNRVTSNDSAIYICGI
AFPSVPEARAKQTGGGTTLVVR
EIKLLSKELRSFLTALVSLLSVYVTGVCVAFILLSKSK
SNPLRNKEIKEDSQKKKSARRIFQEIAQELYHKRHVETNQQSEKDNNTYENRRVLSNYER
P
Sequence length 241
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DERMATITIS, ALLERGIC CONTACT CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Atrial Fibrillation Atrial fibrillation Pubtator 33741890 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 37989761 Associate
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease BEFREE 11132146
★☆☆☆☆
Found in Text Mining only
Dermatitis, Allergic Contact Dermatitis CTD_human_DG 16033404
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Dyssomnias Dyssomnia BEFREE 31659377
★☆☆☆☆
Found in Text Mining only
Gastritis Gastritis Pubtator 36973348 Associate
★☆☆☆☆
Found in Text Mining only
Hypertension Hypertension Pubtator 32888289 Associate
★☆☆☆☆
Found in Text Mining only
Immune System Diseases Immune System Diseases BEFREE 12786995
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory Bowel Disease BEFREE 12786995
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 37063877 Associate
★☆☆☆☆
Found in Text Mining only