Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10237
Gene name	Solute carrier family 35 member B1
Gene symbol	SLC35B1
Synonyms (NCBI Gene)	AXERUGTREL1
Chromosome	17
Chromosome location	17q21.33
Summary	This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcr

Show/Hide all (96)

miRTarBase ID	miRNA	Experiments	Reference
MIRT650464	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT650463	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT650462	hsa-miR-4267	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT650464	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT650463	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT650462	hsa-miR-4267	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT650464	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT650463	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT650462	hsa-miR-4267	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT650464	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT650463	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT650462	hsa-miR-4267	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT621298	hsa-miR-1470	HITS-CLIP	23824327
MIRT621297	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT621296	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621295	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT621294	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT621293	hsa-miR-4469	HITS-CLIP	23824327
MIRT621292	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT621291	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621290	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621289	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT621288	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT621287	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT1360316	hsa-miR-1208	CLIP-seq
MIRT1360317	hsa-miR-452	CLIP-seq
MIRT1360318	hsa-miR-4676-3p	CLIP-seq
MIRT1360319	hsa-miR-668	CLIP-seq
MIRT2106614	hsa-miR-1910	CLIP-seq
MIRT2106615	hsa-miR-337-3p	CLIP-seq
MIRT2106616	hsa-miR-4264	CLIP-seq
MIRT2106617	hsa-miR-4477a	CLIP-seq
MIRT2106618	hsa-miR-455-3p	CLIP-seq
MIRT1360319	hsa-miR-668	CLIP-seq
MIRT2330917	hsa-miR-4446-5p	CLIP-seq
MIRT1360319	hsa-miR-668	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0005459	Function	UDP-galactose transmembrane transporter activity	IBA
GO:0005459	Function	UDP-galactose transmembrane transporter activity	TAS	9010752
GO:0005460	Function	UDP-glucose transmembrane transporter activity	IBA
GO:0005471	Function	ATP:ADP antiporter activity	IDA	30154480
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	30154480
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015786	Process	UDP-glucose transmembrane transport	IEA
GO:0015866	Process	ADP transport	IEA
GO:0015867	Process	ATP transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	9010752
GO:0055085	Process	Transmembrane transport	IEA
GO:0072334	Process	UDP-galactose transmembrane transport	IBA

MIM	HGNC	e!Ensembl
610790	20798	ENSG00000121073

P78383

Protein name

Solute carrier family 35 member B1 (ATP/ADP exchanger ER) (AXER) (Endoplasmic reticulum ATP/ADP translocase) (UDP-galactose transporter-related protein 1) (UGTrel1)

Protein function

ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08449	UAA	13 → 313	UAA transporter family	Family

Sequence

MASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQC
VINAVFAKILIQFFDTARVDRTRSWLYAACSISYLGAMVSSNSALQFVNYPTQVLGKSCK
PIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGYGELLLLLSL
TLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGMGILFTGELWEFLSFAERYPAII
YNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGT
VLVFLGLGLDAKFGKGAKKTSH

Sequence length

322

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLC35B1-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	28533516	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC35B1 (solute carrier family 35 member B1)