COQ7 (coenzyme Q7, hydroxylase)

Gene

• Entrez ID: 10229
• Gene name: Coenzyme Q7, hydroxylase
• Gene symbol: COQ7
• Synonyms (NCBI Gene): CAT5, CLK-1, CLK1, COQ10D8, HMNR9
• Chromosome: 16
• Chromosome location: 16p12.3
• Summary: The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternati

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs864321686	T>A,G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT714280	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT615809	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT615808	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT615806	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT714279	hsa-miR-3926	HITS-CLIP	19536157
MIRT714278	hsa-miR-3671	HITS-CLIP	19536157
MIRT714277	hsa-miR-6828-3p	HITS-CLIP	19536157
MIRT714276	hsa-miR-6071	HITS-CLIP	19536157
MIRT714275	hsa-miR-548s	HITS-CLIP	19536157
MIRT714274	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT714273	hsa-miR-588	HITS-CLIP	19536157
MIRT714272	hsa-miR-4435	HITS-CLIP	19536157
MIRT714271	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT620194	hsa-miR-193a-3p	HITS-CLIP	23824327
MIRT620193	hsa-miR-193b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT620192	hsa-miR-3176	HITS-CLIP	23824327
MIRT620191	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT620190	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT714280	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT615809	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT615808	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT615806	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT714279	hsa-miR-3926	HITS-CLIP	19536157
MIRT714278	hsa-miR-3671	HITS-CLIP	19536157
MIRT714277	hsa-miR-6828-3p	HITS-CLIP	19536157
MIRT714276	hsa-miR-6071	HITS-CLIP	19536157
MIRT714275	hsa-miR-548s	HITS-CLIP	19536157
MIRT714274	hsa-miR-4701-5p	HITS-CLIP	19536157
MIRT714273	hsa-miR-588	HITS-CLIP	19536157
MIRT714272	hsa-miR-4435	HITS-CLIP	19536157
MIRT714271	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT710860	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT710859	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT710858	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT710857	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT710856	hsa-miR-137	HITS-CLIP	19536157
MIRT710855	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT710854	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT710853	hsa-miR-3685	HITS-CLIP	19536157
MIRT710852	hsa-miR-384	HITS-CLIP	19536157
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT620194	hsa-miR-193a-3p	HITS-CLIP	23824327
MIRT620193	hsa-miR-193b-3p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT620192	hsa-miR-3176	HITS-CLIP	23824327
MIRT620191	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT620190	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT615814	hsa-miR-224-5p	HITS-CLIP	23824327
MIRT615813	hsa-miR-3973	HITS-CLIP	23824327
MIRT615812	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT615811	hsa-miR-520h	HITS-CLIP	23824327
MIRT615810	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT615809	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT615808	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT615807	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT615806	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT615805	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT615804	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT615803	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT615802	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT615801	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT615800	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT904439	hsa-miR-1275	CLIP-seq
MIRT904440	hsa-miR-1290	CLIP-seq
MIRT904441	hsa-miR-129-5p	CLIP-seq
MIRT904442	hsa-miR-361-5p	CLIP-seq
MIRT904443	hsa-miR-371-5p	CLIP-seq
MIRT904444	hsa-miR-4260	CLIP-seq
MIRT904445	hsa-miR-4450	CLIP-seq
MIRT904446	hsa-miR-4525	CLIP-seq
MIRT904447	hsa-miR-4665-5p	CLIP-seq
MIRT904448	hsa-miR-4723-5p	CLIP-seq
MIRT904449	hsa-miR-625	CLIP-seq
MIRT904450	hsa-let-7a	CLIP-seq
MIRT904451	hsa-let-7b	CLIP-seq
MIRT904452	hsa-let-7c	CLIP-seq
MIRT904453	hsa-let-7d	CLIP-seq
MIRT904454	hsa-let-7e	CLIP-seq
MIRT904455	hsa-let-7f	CLIP-seq
MIRT904456	hsa-let-7g	CLIP-seq
MIRT904457	hsa-let-7i	CLIP-seq
MIRT904458	hsa-miR-1228	CLIP-seq
MIRT904459	hsa-miR-1251	CLIP-seq
MIRT904460	hsa-miR-1255a	CLIP-seq
MIRT904461	hsa-miR-1255b	CLIP-seq
MIRT904462	hsa-miR-1293	CLIP-seq
MIRT904463	hsa-miR-185	CLIP-seq
MIRT904464	hsa-miR-1909	CLIP-seq
MIRT904465	hsa-miR-202	CLIP-seq
MIRT904466	hsa-miR-2114	CLIP-seq
MIRT904467	hsa-miR-24	CLIP-seq
MIRT904468	hsa-miR-3150b-3p	CLIP-seq
MIRT904469	hsa-miR-3155	CLIP-seq
MIRT904470	hsa-miR-3155b	CLIP-seq
MIRT904471	hsa-miR-3202	CLIP-seq
MIRT904472	hsa-miR-342-3p	CLIP-seq
MIRT904473	hsa-miR-3605-5p	CLIP-seq
MIRT904474	hsa-miR-3616-5p	CLIP-seq
MIRT904475	hsa-miR-3647-5p	CLIP-seq
MIRT904476	hsa-miR-3675-3p	CLIP-seq
MIRT904477	hsa-miR-377	CLIP-seq
MIRT904478	hsa-miR-3929	CLIP-seq
MIRT904479	hsa-miR-4284	CLIP-seq
MIRT904480	hsa-miR-4299	CLIP-seq
MIRT904481	hsa-miR-4306	CLIP-seq
MIRT904482	hsa-miR-4310	CLIP-seq
MIRT904483	hsa-miR-4419b	CLIP-seq
MIRT904484	hsa-miR-4458	CLIP-seq
MIRT904485	hsa-miR-4474-5p	CLIP-seq
MIRT904486	hsa-miR-4478	CLIP-seq
MIRT904487	hsa-miR-4483	CLIP-seq
MIRT904488	hsa-miR-4500	CLIP-seq
MIRT904489	hsa-miR-4506	CLIP-seq
MIRT904490	hsa-miR-4533	CLIP-seq
MIRT904491	hsa-miR-4644	CLIP-seq
MIRT904492	hsa-miR-4683	CLIP-seq
MIRT904493	hsa-miR-4729	CLIP-seq
MIRT904494	hsa-miR-4784	CLIP-seq
MIRT904495	hsa-miR-4795-5p	CLIP-seq
MIRT904496	hsa-miR-484	CLIP-seq
MIRT904497	hsa-miR-495	CLIP-seq
MIRT904498	hsa-miR-573	CLIP-seq
MIRT904499	hsa-miR-890	CLIP-seq
MIRT904500	hsa-miR-98	CLIP-seq
MIRT1968171	hsa-miR-1912	CLIP-seq
MIRT1968172	hsa-miR-3919	CLIP-seq
MIRT1968173	hsa-miR-4275	CLIP-seq
MIRT904489	hsa-miR-4506	CLIP-seq
MIRT2204077	hsa-miR-1273e	CLIP-seq
MIRT904462	hsa-miR-1293	CLIP-seq
MIRT2204078	hsa-miR-1304	CLIP-seq
MIRT2204079	hsa-miR-219-1-3p	CLIP-seq
MIRT2204080	hsa-miR-2467-5p	CLIP-seq
MIRT2204081	hsa-miR-3174	CLIP-seq
MIRT2204082	hsa-miR-3188	CLIP-seq
MIRT2204083	hsa-miR-3975	CLIP-seq
MIRT2204084	hsa-miR-4266	CLIP-seq
MIRT904487	hsa-miR-4483	CLIP-seq
MIRT2204085	hsa-miR-4645-5p	CLIP-seq
MIRT2204086	hsa-miR-4673	CLIP-seq
MIRT2204087	hsa-miR-4695-5p	CLIP-seq
MIRT2204088	hsa-miR-4779	CLIP-seq
MIRT2204089	hsa-miR-485-5p	CLIP-seq
MIRT2204090	hsa-miR-571	CLIP-seq
MIRT2204091	hsa-miR-758	CLIP-seq
MIRT2507467	hsa-miR-1225-3p	CLIP-seq
MIRT904458	hsa-miR-1228	CLIP-seq
MIRT2507468	hsa-miR-1233	CLIP-seq
MIRT2507469	hsa-miR-1273	CLIP-seq
MIRT2507470	hsa-miR-1303	CLIP-seq
MIRT2507471	hsa-miR-3122	CLIP-seq
MIRT2204081	hsa-miR-3174	CLIP-seq
MIRT2507472	hsa-miR-3672	CLIP-seq
MIRT2507473	hsa-miR-3683	CLIP-seq
MIRT2507474	hsa-miR-3913-5p	CLIP-seq
MIRT2507475	hsa-miR-4420	CLIP-seq
MIRT2507476	hsa-miR-4433	CLIP-seq
MIRT2507477	hsa-miR-4653-3p	CLIP-seq
MIRT2507478	hsa-miR-4747-5p	CLIP-seq
MIRT2507479	hsa-miR-4786-5p	CLIP-seq
MIRT2507480	hsa-miR-665	CLIP-seq
MIRT2507481	hsa-miR-921	CLIP-seq
MIRT904458	hsa-miR-1228	CLIP-seq
MIRT2678478	hsa-miR-1276	CLIP-seq
MIRT2678479	hsa-miR-1291	CLIP-seq
MIRT2678480	hsa-miR-146b-3p	CLIP-seq
MIRT2507471	hsa-miR-3122	CLIP-seq
MIRT2678481	hsa-miR-339-5p	CLIP-seq
MIRT2507474	hsa-miR-3913-5p	CLIP-seq
MIRT2678482	hsa-miR-4421	CLIP-seq
MIRT2507478	hsa-miR-4747-5p	CLIP-seq
MIRT2678483	hsa-miR-515-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	25961505
GO:0003682	Function	Chromatin binding	IDA	25961505
GO:0004497	Function	Monooxygenase activity	IEA
GO:0005515	Function	Protein binding	IPI	25339443, 27499296, 30661980
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	25961505
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	25961505
GO:0005739	Component	Mitochondrion	IDA	25961505
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	27499296
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006744	Process	Ubiquinone biosynthetic process	IBA
GO:0006744	Process	Ubiquinone biosynthetic process	IDA	38425362
GO:0006744	Process	Ubiquinone biosynthetic process	IEA
GO:0006744	Process	Ubiquinone biosynthetic process	IMP	28409910
GO:0006744	Process	Ubiquinone biosynthetic process	NAS	28927698
GO:0008340	Process	Determination of adult lifespan	IBA
GO:0008682	Function	3-demethoxyubiquinol 3-hydroxylase activity	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016709	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA
GO:0031314	Component	Extrinsic component of mitochondrial inner membrane	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	25961505
GO:0046872	Function	Metal ion binding	IEA
GO:0110142	Component	Ubiquinone biosynthesis complex	IPI	27499296
GO:0160224	Function	3-demethoxyubiquinone 3-hydroxylase (NADH) activity	IDA	38425362
GO:0160224	Function	3-demethoxyubiquinone 3-hydroxylase (NADH) activity	IEA
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	IBA
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	IMP	25961505

Other IDs

• MIM: 601683
• HGNC: 2244
• e!Ensembl: ENSG00000167186

Protein

• UniProt ID: Q99807
• Protein name: NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial (EC 1.14.13.253) (3-demethoxyubiquinone 3-hydroxylase (NADH)) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)
• Protein function: Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (Probable). Catalyzes the reaction through a substrate-mediated reduction pathway, w
• PDB: 7SSP, 7SSS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03232	COQ7	48 → 217	Ubiquinone biosynthesis protein COQ7	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed dominantly in heart and skeletal muscle. {ECO:0000269|PubMed:10373327}.
• Sequence:

  MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDNISRAAVDRIIRVDHAGE
  YGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGF
  ALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELE
  HHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL

• Sequence length: 217

Pathways

KEGG:

Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of cofactors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neuronopathy, distal hereditary motor, autosomal recessive 9	Pathogenic	rs1436765596, rs2509348557, rs1400703292	RCV003336608 RCV003336609 RCV003336610 RCV003336611	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Primary coenzyme Q10 deficiency 8	Likely pathogenic; Pathogenic	rs2142400288, rs864321686, rs138490803, rs2509308079, rs2509349181, rs2509372929, rs1962955145	RCV002249833 RCV000203513 RCV003239277 RCV003335902 RCV003986081 RCV003986082 RCV001257088	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COENZYME Q10 DEFICIENCY, PRIMARY, 8	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COQ7-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COQ7-RELATED DISTAL HEREDITARY MOTOR NEUROPATHY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Clumsiness - motor delay	Motor delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
COENZYME Q10 DEFICIENCY	Coenzyme Q10 Deficiency	BEFREE	23255162, 26084283		★☆☆☆☆ Found in Text Mining only
Coenzyme Q10 Deficiency	Coenzyme q10 deficiency	Pubtator	26084283, 36454683, 37392700	Associate	★☆☆☆☆ Found in Text Mining only
COENZYME Q10 DEFICIENCY, PRIMARY, 8	Coenzyme Q10 Deficiency	GENOMICS_ENGLAND_DG	26084283, 28409910, 30369941		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COENZYME Q10 DEFICIENCY, PRIMARY, 8	Coenzyme Q10 Deficiency	UNIPROT_DG	26084283		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COENZYME Q10 DEFICIENCY, PRIMARY, 8	Coenzyme Q10 Deficiency	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COENZYME Q10 DEFICIENCY, PRIMARY, 8	Coenzyme Q10 Deficiency	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital hypoplasia of lung	Pulmonary hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	36454683	Associate	★☆☆☆☆ Found in Text Mining only
Distal Hereditary Motor Neuropathy Type II	Distal hereditary motor neuropathy	Pubtator	36454683, 37170631	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	BEFREE	29695603		★☆☆☆☆ Found in Text Mining only
Left Ventricular Hypertrophy	Left Ventricular Hypertrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Mitochondrial Complex II Deficiency	Mitochondrial complex deficiency	Pubtator	26084283	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	26690054, 37170631	Associate	★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	37392700	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	18927074		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	LHGDN	18927074		★☆☆☆☆ Found in Text Mining only
Polyneuropathy	Polyneuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Renal Cell Dysplasia	Renal dysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Renal dysplasia	Renal dysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Steroid resistant nephrotic syndrome of childhood	Steroid resistant nephrotic syndrome	BEFREE	24270420		★☆☆☆☆ Found in Text Mining only