Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10220
Gene name	Growth differentiation factor 11
Gene symbol	GDF11
Synonyms (NCBI Gene)	BMP-11BMP11VHO
Chromosome	12
Chromosome location	12q13.2
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate

440

Show/Hide all (440)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029928	hsa-miR-26b-5p	Microarray	19088304
MIRT052163	hsa-let-7b-5p	CLASH	23622248
MIRT050946	hsa-miR-17-5p	CLASH	23622248
MIRT040960	hsa-miR-18a-3p	CLASH	23622248
MIRT040475	hsa-miR-615-3p	CLASH	23622248
MIRT038028	hsa-miR-423-5p	CLASH	23622248
MIRT724570	hsa-miR-8485	HITS-CLIP	19536157
MIRT724569	hsa-miR-1913	HITS-CLIP	19536157
MIRT724568	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT724567	hsa-miR-4313	HITS-CLIP	19536157
MIRT065871	hsa-miR-520e	PAR-CLIP	21572407
MIRT065877	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT065866	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT065876	hsa-miR-520b	PAR-CLIP	21572407
MIRT065873	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT065868	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT065881	hsa-miR-302e	PAR-CLIP	21572407
MIRT065867	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT065869	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT065864	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT065879	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT065865	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT065878	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT065874	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT065859	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT065860	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT050946	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT065863	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT065870	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT065858	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT065884	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT065862	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT542954	hsa-miR-3609	PAR-CLIP	21572407
MIRT542953	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT542952	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT065880	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT065875	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT065872	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT542951	hsa-miR-4760-3p	PAR-CLIP	21572407
MIRT065883	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT542950	hsa-miR-6834-3p	PAR-CLIP	21572407
MIRT542949	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT542948	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT065882	hsa-miR-3912-5p	PAR-CLIP	21572407
MIRT495318	hsa-miR-193a-3p	PAR-CLIP	23708386
MIRT495317	hsa-miR-193b-3p	PAR-CLIP	23708386
MIRT495316	hsa-miR-4716-3p	PAR-CLIP	23708386
MIRT495315	hsa-miR-6794-5p	PAR-CLIP	23708386
MIRT495314	hsa-miR-3127-3p	PAR-CLIP	23708386
MIRT495313	hsa-miR-6756-3p	PAR-CLIP	23708386
MIRT495312	hsa-miR-3190-5p	PAR-CLIP	23708386
MIRT495311	hsa-miR-3926	PAR-CLIP	23708386
MIRT495310	hsa-miR-548s	PAR-CLIP	23708386
MIRT724570	hsa-miR-8485	HITS-CLIP	19536157
MIRT724569	hsa-miR-1913	HITS-CLIP	19536157
MIRT724568	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT724567	hsa-miR-4313	HITS-CLIP	19536157
MIRT065871	hsa-miR-520e	PAR-CLIP	21572407
MIRT065877	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT065866	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT065876	hsa-miR-520b	PAR-CLIP	21572407
MIRT065873	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT065868	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT065881	hsa-miR-302e	PAR-CLIP	21572407
MIRT065867	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT065869	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT065864	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT065879	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT065865	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT065878	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT065874	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT065859	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT065860	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT050946	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT065863	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT065870	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT065858	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT065884	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT065862	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT542954	hsa-miR-3609	PAR-CLIP	21572407
MIRT542953	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT542952	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT065880	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT065875	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT065872	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT542951	hsa-miR-4760-3p	PAR-CLIP	21572407
MIRT065883	hsa-miR-371b-3p	PAR-CLIP	21572407
MIRT542950	hsa-miR-6834-3p	PAR-CLIP	21572407
MIRT542949	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT542948	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT065882	hsa-miR-3912-5p	PAR-CLIP	21572407
MIRT495318	hsa-miR-193a-3p	PAR-CLIP	23708386
MIRT495317	hsa-miR-193b-3p	PAR-CLIP	23708386
MIRT495316	hsa-miR-4716-3p	PAR-CLIP	23708386
MIRT495315	hsa-miR-6794-5p	PAR-CLIP	23708386
MIRT495314	hsa-miR-3127-3p	PAR-CLIP	23708386
MIRT495313	hsa-miR-6756-3p	PAR-CLIP	23708386
MIRT495312	hsa-miR-3190-5p	PAR-CLIP	23708386
MIRT495311	hsa-miR-3926	PAR-CLIP	23708386
MIRT495310	hsa-miR-548s	PAR-CLIP	23708386
MIRT1015631	hsa-miR-106a	CLIP-seq
MIRT1015632	hsa-miR-106b	CLIP-seq
MIRT1015633	hsa-miR-1207-5p	CLIP-seq
MIRT1015634	hsa-miR-1226	CLIP-seq
MIRT1015635	hsa-miR-1245b-3p	CLIP-seq
MIRT1015636	hsa-miR-128	CLIP-seq
MIRT1015637	hsa-miR-145	CLIP-seq
MIRT1015638	hsa-miR-1587	CLIP-seq
MIRT1015639	hsa-miR-17	CLIP-seq
MIRT1015640	hsa-miR-1909	CLIP-seq
MIRT1015641	hsa-miR-192	CLIP-seq
MIRT1015642	hsa-miR-20a	CLIP-seq
MIRT1015643	hsa-miR-20b	CLIP-seq
MIRT1015644	hsa-miR-215	CLIP-seq
MIRT1015645	hsa-miR-2355-5p	CLIP-seq
MIRT1015646	hsa-miR-296-3p	CLIP-seq
MIRT1015647	hsa-miR-302a	CLIP-seq
MIRT1015648	hsa-miR-302b	CLIP-seq
MIRT1015649	hsa-miR-302c	CLIP-seq
MIRT1015650	hsa-miR-302d	CLIP-seq
MIRT1015651	hsa-miR-3140-3p	CLIP-seq
MIRT1015652	hsa-miR-3148	CLIP-seq
MIRT1015653	hsa-miR-3150b-3p	CLIP-seq
MIRT1015654	hsa-miR-3170	CLIP-seq
MIRT1015655	hsa-miR-3188	CLIP-seq
MIRT1015656	hsa-miR-3620	CLIP-seq
MIRT1015657	hsa-miR-3646	CLIP-seq
MIRT1015658	hsa-miR-3679-3p	CLIP-seq
MIRT1015659	hsa-miR-372	CLIP-seq
MIRT1015660	hsa-miR-373	CLIP-seq
MIRT1015661	hsa-miR-4265	CLIP-seq
MIRT1015662	hsa-miR-4286	CLIP-seq
MIRT1015663	hsa-miR-4290	CLIP-seq
MIRT1015664	hsa-miR-4296	CLIP-seq
MIRT1015665	hsa-miR-4312	CLIP-seq
MIRT1015666	hsa-miR-4322	CLIP-seq
MIRT1015667	hsa-miR-4328	CLIP-seq
MIRT1015668	hsa-miR-4446-5p	CLIP-seq
MIRT1015669	hsa-miR-4453	CLIP-seq
MIRT1015670	hsa-miR-4480	CLIP-seq
MIRT1015671	hsa-miR-4506	CLIP-seq
MIRT1015672	hsa-miR-4535	CLIP-seq
MIRT1015673	hsa-miR-4538	CLIP-seq
MIRT1015674	hsa-miR-4640-5p	CLIP-seq
MIRT1015675	hsa-miR-4645-3p	CLIP-seq
MIRT1015676	hsa-miR-4648	CLIP-seq
MIRT1015677	hsa-miR-4654	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT1015679	hsa-miR-4674	CLIP-seq
MIRT1015680	hsa-miR-4726-5p	CLIP-seq
MIRT1015681	hsa-miR-4731-3p	CLIP-seq
MIRT1015682	hsa-miR-4732-3p	CLIP-seq
MIRT1015683	hsa-miR-4733-3p	CLIP-seq
MIRT1015684	hsa-miR-4747-5p	CLIP-seq
MIRT1015685	hsa-miR-4763-3p	CLIP-seq
MIRT1015686	hsa-miR-4769-5p	CLIP-seq
MIRT1015687	hsa-miR-4784	CLIP-seq
MIRT1015688	hsa-miR-4789-5p	CLIP-seq
MIRT1015689	hsa-miR-4800-5p	CLIP-seq
MIRT1015690	hsa-miR-4801	CLIP-seq
MIRT1015691	hsa-miR-492	CLIP-seq
MIRT1015692	hsa-miR-519a	CLIP-seq
MIRT1015693	hsa-miR-519d	CLIP-seq
MIRT1015694	hsa-miR-542-3p	CLIP-seq
MIRT1015695	hsa-miR-544b	CLIP-seq
MIRT1015696	hsa-miR-548a-5p	CLIP-seq
MIRT1015697	hsa-miR-548ab	CLIP-seq
MIRT1015698	hsa-miR-548ah	CLIP-seq
MIRT1015699	hsa-miR-548ak	CLIP-seq
MIRT1015700	hsa-miR-548b-5p	CLIP-seq
MIRT1015701	hsa-miR-548c-5p	CLIP-seq
MIRT1015702	hsa-miR-548d-5p	CLIP-seq
MIRT1015703	hsa-miR-548h	CLIP-seq
MIRT1015704	hsa-miR-548i	CLIP-seq
MIRT1015705	hsa-miR-548j	CLIP-seq
MIRT1015706	hsa-miR-548k	CLIP-seq
MIRT1015707	hsa-miR-548l	CLIP-seq
MIRT1015708	hsa-miR-548w	CLIP-seq
MIRT1015709	hsa-miR-548y	CLIP-seq
MIRT1015710	hsa-miR-553	CLIP-seq
MIRT1015711	hsa-miR-559	CLIP-seq
MIRT1015712	hsa-miR-629	CLIP-seq
MIRT1015713	hsa-miR-635	CLIP-seq
MIRT1015714	hsa-miR-93	CLIP-seq
MIRT1015715	hsa-miR-944	CLIP-seq
MIRT1015641	hsa-miR-192	CLIP-seq
MIRT1015644	hsa-miR-215	CLIP-seq
MIRT1015641	hsa-miR-192	CLIP-seq
MIRT1015644	hsa-miR-215	CLIP-seq
MIRT1015670	hsa-miR-4480	CLIP-seq
MIRT1015631	hsa-miR-106a	CLIP-seq
MIRT1015632	hsa-miR-106b	CLIP-seq
MIRT2000698	hsa-miR-1224-3p	CLIP-seq
MIRT2000699	hsa-miR-1260	CLIP-seq
MIRT2000700	hsa-miR-1260b	CLIP-seq
MIRT2000701	hsa-miR-1278	CLIP-seq
MIRT2000702	hsa-miR-1280	CLIP-seq
MIRT2000703	hsa-miR-149	CLIP-seq
MIRT1015638	hsa-miR-1587	CLIP-seq
MIRT1015639	hsa-miR-17	CLIP-seq
MIRT2000704	hsa-miR-188-3p	CLIP-seq
MIRT1015641	hsa-miR-192	CLIP-seq
MIRT2000705	hsa-miR-198	CLIP-seq
MIRT2000706	hsa-miR-202	CLIP-seq
MIRT1015642	hsa-miR-20a	CLIP-seq
MIRT1015643	hsa-miR-20b	CLIP-seq
MIRT2000707	hsa-miR-2117	CLIP-seq
MIRT1015644	hsa-miR-215	CLIP-seq
MIRT1015647	hsa-miR-302a	CLIP-seq
MIRT1015648	hsa-miR-302b	CLIP-seq
MIRT1015649	hsa-miR-302c	CLIP-seq
MIRT1015650	hsa-miR-302d	CLIP-seq
MIRT2000708	hsa-miR-3064-5p	CLIP-seq
MIRT1015653	hsa-miR-3150b-3p	CLIP-seq
MIRT2000709	hsa-miR-3174	CLIP-seq
MIRT2000710	hsa-miR-3185	CLIP-seq
MIRT2000711	hsa-miR-3192	CLIP-seq
MIRT2000712	hsa-miR-3689a-3p	CLIP-seq
MIRT2000713	hsa-miR-3689c	CLIP-seq
MIRT1015659	hsa-miR-372	CLIP-seq
MIRT1015660	hsa-miR-373	CLIP-seq
MIRT2000714	hsa-miR-412	CLIP-seq
MIRT1015663	hsa-miR-4290	CLIP-seq
MIRT2000715	hsa-miR-4419a	CLIP-seq
MIRT1015670	hsa-miR-4480	CLIP-seq
MIRT1015671	hsa-miR-4506	CLIP-seq
MIRT2000716	hsa-miR-4510	CLIP-seq
MIRT2000717	hsa-miR-452	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT1015679	hsa-miR-4674	CLIP-seq
MIRT2000718	hsa-miR-4676-3p	CLIP-seq
MIRT2000719	hsa-miR-4678	CLIP-seq
MIRT2000720	hsa-miR-4709-3p	CLIP-seq
MIRT2000721	hsa-miR-4713-5p	CLIP-seq
MIRT2000722	hsa-miR-4728-5p	CLIP-seq
MIRT1015687	hsa-miR-4784	CLIP-seq
MIRT2000723	hsa-miR-4794	CLIP-seq
MIRT1015692	hsa-miR-519a	CLIP-seq
MIRT1015693	hsa-miR-519d	CLIP-seq
MIRT2000724	hsa-miR-520a-5p	CLIP-seq
MIRT2000725	hsa-miR-525-5p	CLIP-seq
MIRT1015698	hsa-miR-548ah	CLIP-seq
MIRT1015713	hsa-miR-635	CLIP-seq
MIRT1015714	hsa-miR-93	CLIP-seq
MIRT2234176	hsa-miR-1236	CLIP-seq
MIRT2234177	hsa-miR-129-5p	CLIP-seq
MIRT2234178	hsa-miR-136	CLIP-seq
MIRT2234179	hsa-miR-146b-3p	CLIP-seq
MIRT2000704	hsa-miR-188-3p	CLIP-seq
MIRT1015641	hsa-miR-192	CLIP-seq
MIRT2234180	hsa-miR-197	CLIP-seq
MIRT2000706	hsa-miR-202	CLIP-seq
MIRT1015644	hsa-miR-215	CLIP-seq
MIRT2234181	hsa-miR-3173-5p	CLIP-seq
MIRT2234182	hsa-miR-3664-5p	CLIP-seq
MIRT2000714	hsa-miR-412	CLIP-seq
MIRT2234183	hsa-miR-4264	CLIP-seq
MIRT2234184	hsa-miR-4299	CLIP-seq
MIRT2234185	hsa-miR-4456	CLIP-seq
MIRT1015670	hsa-miR-4480	CLIP-seq
MIRT2000717	hsa-miR-452	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT2000718	hsa-miR-4676-3p	CLIP-seq
MIRT2000719	hsa-miR-4678	CLIP-seq
MIRT2234186	hsa-miR-4714-5p	CLIP-seq
MIRT2234187	hsa-miR-4755-3p	CLIP-seq
MIRT2234188	hsa-miR-4760-5p	CLIP-seq
MIRT2234189	hsa-miR-4797-3p	CLIP-seq
MIRT2234190	hsa-miR-548q	CLIP-seq
MIRT2234191	hsa-miR-874	CLIP-seq
MIRT1015633	hsa-miR-1207-5p	CLIP-seq
MIRT1015640	hsa-miR-1909	CLIP-seq
MIRT1015663	hsa-miR-4290	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT1015685	hsa-miR-4763-3p	CLIP-seq
MIRT2442184	hsa-miR-193b	CLIP-seq
MIRT2442185	hsa-miR-4749-3p	CLIP-seq
MIRT1015631	hsa-miR-106a	CLIP-seq
MIRT1015632	hsa-miR-106b	CLIP-seq
MIRT2234176	hsa-miR-1236	CLIP-seq
MIRT2538177	hsa-miR-1254	CLIP-seq
MIRT2538178	hsa-miR-1256	CLIP-seq
MIRT2234177	hsa-miR-129-5p	CLIP-seq
MIRT2538179	hsa-miR-1343	CLIP-seq
MIRT2538180	hsa-miR-140-5p	CLIP-seq
MIRT2234179	hsa-miR-146b-3p	CLIP-seq
MIRT2538181	hsa-miR-1470	CLIP-seq
MIRT1015639	hsa-miR-17	CLIP-seq
MIRT2000704	hsa-miR-188-3p	CLIP-seq
MIRT2234180	hsa-miR-197	CLIP-seq
MIRT2000706	hsa-miR-202	CLIP-seq
MIRT1015642	hsa-miR-20a	CLIP-seq
MIRT1015643	hsa-miR-20b	CLIP-seq
MIRT2538182	hsa-miR-3074-5p	CLIP-seq
MIRT2538183	hsa-miR-3116	CLIP-seq
MIRT2538184	hsa-miR-3124-3p	CLIP-seq
MIRT2538185	hsa-miR-3156-3p	CLIP-seq
MIRT2538186	hsa-miR-3160-3p	CLIP-seq
MIRT2234181	hsa-miR-3173-5p	CLIP-seq
MIRT2000710	hsa-miR-3185	CLIP-seq
MIRT2538187	hsa-miR-3189-3p	CLIP-seq
MIRT2538188	hsa-miR-323-5p	CLIP-seq
MIRT2234182	hsa-miR-3664-5p	CLIP-seq
MIRT2538189	hsa-miR-3691-3p	CLIP-seq
MIRT2538190	hsa-miR-3691-5p	CLIP-seq
MIRT2538191	hsa-miR-3911	CLIP-seq
MIRT2538192	hsa-miR-3913-3p	CLIP-seq
MIRT2538193	hsa-miR-3940-5p	CLIP-seq
MIRT2000714	hsa-miR-412	CLIP-seq
MIRT2538194	hsa-miR-4254	CLIP-seq
MIRT2234183	hsa-miR-4264	CLIP-seq
MIRT2234184	hsa-miR-4299	CLIP-seq
MIRT2538195	hsa-miR-4301	CLIP-seq
MIRT2538196	hsa-miR-4433	CLIP-seq
MIRT2538197	hsa-miR-4455	CLIP-seq
MIRT2234185	hsa-miR-4456	CLIP-seq
MIRT2538198	hsa-miR-4459	CLIP-seq
MIRT2538199	hsa-miR-4487	CLIP-seq
MIRT2538200	hsa-miR-4507	CLIP-seq
MIRT2538201	hsa-miR-450b-5p	CLIP-seq
MIRT2538202	hsa-miR-4663	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT2000719	hsa-miR-4678	CLIP-seq
MIRT2538203	hsa-miR-4695-3p	CLIP-seq
MIRT2000720	hsa-miR-4709-3p	CLIP-seq
MIRT2234186	hsa-miR-4714-5p	CLIP-seq
MIRT2538204	hsa-miR-4720-5p	CLIP-seq
MIRT2442185	hsa-miR-4749-3p	CLIP-seq
MIRT2538205	hsa-miR-4752	CLIP-seq
MIRT2538206	hsa-miR-4768-3p	CLIP-seq
MIRT2538207	hsa-miR-4772-5p	CLIP-seq
MIRT2234189	hsa-miR-4797-3p	CLIP-seq
MIRT2538208	hsa-miR-4799-3p	CLIP-seq
MIRT2538209	hsa-miR-489	CLIP-seq
MIRT2538210	hsa-miR-507	CLIP-seq
MIRT2538211	hsa-miR-513c	CLIP-seq
MIRT2538212	hsa-miR-514b-5p	CLIP-seq
MIRT1015693	hsa-miR-519d	CLIP-seq
MIRT2538213	hsa-miR-548a-3p	CLIP-seq
MIRT1015698	hsa-miR-548ah	CLIP-seq
MIRT2538214	hsa-miR-548e	CLIP-seq
MIRT2538215	hsa-miR-548f	CLIP-seq
MIRT2234190	hsa-miR-548q	CLIP-seq
MIRT2538216	hsa-miR-557	CLIP-seq
MIRT2538217	hsa-miR-558	CLIP-seq
MIRT2538218	hsa-miR-570	CLIP-seq
MIRT2538219	hsa-miR-628-5p	CLIP-seq
MIRT2538220	hsa-miR-642a	CLIP-seq
MIRT2538221	hsa-miR-645	CLIP-seq
MIRT2538222	hsa-miR-661	CLIP-seq
MIRT2538223	hsa-miR-665	CLIP-seq
MIRT2538224	hsa-miR-671-5p	CLIP-seq
MIRT2234191	hsa-miR-874	CLIP-seq
MIRT2538225	hsa-miR-876-3p	CLIP-seq
MIRT1015714	hsa-miR-93	CLIP-seq
MIRT2681487	hsa-miR-1207-3p	CLIP-seq
MIRT2234176	hsa-miR-1236	CLIP-seq
MIRT2538177	hsa-miR-1254	CLIP-seq
MIRT2681488	hsa-miR-1275	CLIP-seq
MIRT2234177	hsa-miR-129-5p	CLIP-seq
MIRT2538179	hsa-miR-1343	CLIP-seq
MIRT2538180	hsa-miR-140-5p	CLIP-seq
MIRT2234179	hsa-miR-146b-3p	CLIP-seq
MIRT2538181	hsa-miR-1470	CLIP-seq
MIRT2681489	hsa-miR-1827	CLIP-seq
MIRT2000704	hsa-miR-188-3p	CLIP-seq
MIRT2234180	hsa-miR-197	CLIP-seq
MIRT2000705	hsa-miR-198	CLIP-seq
MIRT2000706	hsa-miR-202	CLIP-seq
MIRT2681490	hsa-miR-2114	CLIP-seq
MIRT2538182	hsa-miR-3074-5p	CLIP-seq
MIRT2538183	hsa-miR-3116	CLIP-seq
MIRT2538184	hsa-miR-3124-3p	CLIP-seq
MIRT2538185	hsa-miR-3156-3p	CLIP-seq
MIRT2538186	hsa-miR-3160-3p	CLIP-seq
MIRT2234181	hsa-miR-3173-5p	CLIP-seq
MIRT2000710	hsa-miR-3185	CLIP-seq
MIRT2538187	hsa-miR-3189-3p	CLIP-seq
MIRT2000711	hsa-miR-3192	CLIP-seq
MIRT2538188	hsa-miR-323-5p	CLIP-seq
MIRT2681491	hsa-miR-3612	CLIP-seq
MIRT2681492	hsa-miR-3622a-5p	CLIP-seq
MIRT2234182	hsa-miR-3664-5p	CLIP-seq
MIRT2000712	hsa-miR-3689a-3p	CLIP-seq
MIRT2000713	hsa-miR-3689c	CLIP-seq
MIRT2538189	hsa-miR-3691-3p	CLIP-seq
MIRT2538190	hsa-miR-3691-5p	CLIP-seq
MIRT2538191	hsa-miR-3911	CLIP-seq
MIRT2538192	hsa-miR-3913-3p	CLIP-seq
MIRT2538193	hsa-miR-3940-5p	CLIP-seq
MIRT2000714	hsa-miR-412	CLIP-seq
MIRT2538194	hsa-miR-4254	CLIP-seq
MIRT2681493	hsa-miR-4260	CLIP-seq
MIRT2234183	hsa-miR-4264	CLIP-seq
MIRT2681494	hsa-miR-4267	CLIP-seq
MIRT2234184	hsa-miR-4299	CLIP-seq
MIRT2538195	hsa-miR-4301	CLIP-seq
MIRT2681495	hsa-miR-4423-3p	CLIP-seq
MIRT2538196	hsa-miR-4433	CLIP-seq
MIRT2538197	hsa-miR-4455	CLIP-seq
MIRT2234185	hsa-miR-4456	CLIP-seq
MIRT2538198	hsa-miR-4459	CLIP-seq
MIRT2538199	hsa-miR-4487	CLIP-seq
MIRT2538200	hsa-miR-4507	CLIP-seq
MIRT2538201	hsa-miR-450b-5p	CLIP-seq
MIRT2681496	hsa-miR-4639-3p	CLIP-seq
MIRT2538202	hsa-miR-4663	CLIP-seq
MIRT2681497	hsa-miR-4665-5p	CLIP-seq
MIRT1015678	hsa-miR-4667-3p	CLIP-seq
MIRT2000719	hsa-miR-4678	CLIP-seq
MIRT2538203	hsa-miR-4695-3p	CLIP-seq
MIRT2000720	hsa-miR-4709-3p	CLIP-seq
MIRT2234186	hsa-miR-4714-5p	CLIP-seq
MIRT2000722	hsa-miR-4728-5p	CLIP-seq
MIRT2538205	hsa-miR-4752	CLIP-seq
MIRT2538206	hsa-miR-4768-3p	CLIP-seq
MIRT2538207	hsa-miR-4772-5p	CLIP-seq
MIRT2234189	hsa-miR-4797-3p	CLIP-seq
MIRT2538209	hsa-miR-489	CLIP-seq
MIRT2538210	hsa-miR-507	CLIP-seq
MIRT2538211	hsa-miR-513c	CLIP-seq
MIRT2538212	hsa-miR-514b-5p	CLIP-seq
MIRT2538213	hsa-miR-548a-3p	CLIP-seq
MIRT2538214	hsa-miR-548e	CLIP-seq
MIRT2538215	hsa-miR-548f	CLIP-seq
MIRT2234190	hsa-miR-548q	CLIP-seq
MIRT2681498	hsa-miR-550a	CLIP-seq
MIRT2538216	hsa-miR-557	CLIP-seq
MIRT2538217	hsa-miR-558	CLIP-seq
MIRT2538218	hsa-miR-570	CLIP-seq
MIRT2538219	hsa-miR-628-5p	CLIP-seq
MIRT2538220	hsa-miR-642a	CLIP-seq
MIRT2538221	hsa-miR-645	CLIP-seq
MIRT2681499	hsa-miR-650	CLIP-seq
MIRT2538222	hsa-miR-661	CLIP-seq
MIRT2538223	hsa-miR-665	CLIP-seq
MIRT2538224	hsa-miR-671-5p	CLIP-seq
MIRT2234191	hsa-miR-874	CLIP-seq
MIRT2538225	hsa-miR-876-3p	CLIP-seq
MIRT2681500	hsa-miR-9	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IEA
GO:0001501	Process	Skeletal system development	TAS	10391213
GO:0001656	Process	Metanephros development	IEA
GO:0001657	Process	Ureteric bud development	IEA
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	18596030, 21054789, 28257634, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0007399	Process	Nervous system development	TAS	10075854
GO:0007498	Process	Mesoderm development	TAS	10075854
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0021512	Process	Spinal cord anterior/posterior patterning	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0031016	Process	Pancreas development	IEA
GO:0032924	Process	Activin receptor signaling pathway	IMP	28257634
GO:0032991	Component	Protein-containing complex	IDA	24019467
GO:0035881	Process	Amacrine cell differentiation	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0048593	Process	Camera-type eye morphogenesis	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0060391	Process	Positive regulation of SMAD protein signal transduction	IEA
GO:0060391	Process	Positive regulation of SMAD protein signal transduction	IMP	28257634
GO:0072560	Process	Type B pancreatic cell maturation	IEA
GO:1902870	Process	Negative regulation of amacrine cell differentiation	IEA

MIM	HGNC	e!Ensembl
603936	4216	ENSG00000135414

O95390

Protein name

Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)

Protein function

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and o

PDB

5E4G , 5JHW , 5UHM , 6MAC , 7MRZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00688	TGFb_propeptide	60 → 298	TGF-beta propeptide	Family
PF00019	TGF_beta	312 → 406	Transforming growth factor beta like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue

Sequence

MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS

Sequence length

407

Interactions

View interactions

	KEGG
	Cytokine-cytokine receptor interaction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Orofacial cleft	Likely pathogenic; Pathogenic	rs1878258280	RCV001261824	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Vertebral hypersegmentation and orofacial anomalies	Likely pathogenic; Pathogenic	rs1878258280	RCV001270146	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GDF11-associated multiple congenital anomalies and ID	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GDF11-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (84)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28170441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplasia	Anaplasia	BEFREE	30462553		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	30727851, 31530563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	Pubtator	30727851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Aplastic	Aplastic anemia	Pubtator	30727851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Dyserythropoietic Congenital	Congenital dyserythropoietic anemia	Pubtator	32759740	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia Nervosa	Anorexia	BEFREE	30281844		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aplastic Anemia	Aplastic anemia	BEFREE	30727851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	27502608, 30188752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	30407878		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33855071	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	39237910	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	27502608, 30188752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrophy of kidney	Atrophy Of Kidney	BEFREE	29731246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26979459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33174245, 33684566	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	34691034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	39415706	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	27565745, 28223232, 29113418		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cavitary Optic Disc Anomalies	Cavitary optic disc anomalies	Pubtator	17368552	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	29432795		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29432795, 30061815		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	28455454, 29680737, 29731621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	31215115	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	30188752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	17912435, 29545874, 30889293		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	17912435		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital exomphalos	Congenital Exomphalos	BEFREE	18519639		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital omphalocele	Congenital omphalocele	BEFREE	18519639		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30900023, 30942402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	27565745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	30259241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	30026260		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	30026260		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	36631441	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28450417, 30897065		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	30213293		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	30213293		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	31767630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	BEFREE	31248139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30900023, 30942402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	26979459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	33684566	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31248139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	30714521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic obstructive cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	30714521		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	Pubtator	39237910	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	34691034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	29463625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28611236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory dermatosis	Dermatitis	BEFREE	30259241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	33684566	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron Overload	BEFREE	29903757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	29731246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure	Kidney Failure	BEFREE	29731246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30890427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29161592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	30213293		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	29545874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30568460		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17912435, 29113418, 31681577		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	31637864, 31847906		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	29903757, 30602619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	28004242, 30900023, 31292540		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	39463227	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	BEFREE	27565745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	36631441	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17912435, 29161592, 29545874, 30568460, 30889293, 30890427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	31330871		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28485800, 30897065, 31847906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	33684566	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Orofacial Cleft 1	Orofacial cleft	Pubtator	31215115, 34061439	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	25534870, 30279140		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30568460		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Myelofibrosis	Myelofibrosis	BEFREE	30602619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	29463625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	29731621	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal fibrosis	Renal fibrosis	BEFREE	29731246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	30407878		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29161592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	30188752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uremia	Uremia	BEFREE	28223232		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	30883611		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	30883611	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GDF11 (growth differentiation factor 11)