Gene Gene information from NCBI Gene database.
Entrez ID 10209
Gene name Eukaryotic translation initiation factor 1
Gene symbol EIF1
Synonyms (NCBI Gene)
A121EIF-1EIF1AISO1SUI1
Chromosome 17
Chromosome location 17q21.2
miRNA miRNA information provided by mirtarbase database.
1010
miRTarBase ID miRNA Experiments Reference
MIRT028444 hsa-miR-30a-5p Proteomics 18668040
MIRT031390 hsa-miR-16-5p Proteomics 18668040
MIRT047677 hsa-miR-10a-5p CLASH 23622248
MIRT047434 hsa-miR-10b-5p CLASH 23622248
MIRT044979 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IBA
GO:0003743 Function Translation initiation factor activity IBA
GO:0003743 Function Translation initiation factor activity IDA 12435632, 29987188
GO:0003743 Function Translation initiation factor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619901 3249 ENSG00000173812
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41567
Protein name Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)
Protein function Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:12435632, PubMed:14600024, PubMed:9732867). Together with eIF1A (EIF1
PDB 2IF1 , 4KZX , 4KZY , 6YBW , 6ZMW , 6ZP4 , 6ZVJ , 7A09 , 7QP6 , 8PJ1 , 8PPK , 8PPL , 8XXN , 9BLN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01253 SUI1 27 103 Translation initiation factor SUI1 Domain
Sequence
Sequence length 113
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DUODENAL ULCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma BEFREE 31708110
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 34416429 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30692100, 31836680
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 33597508 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 36497197 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 26386724 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 16929481
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 19683863, 26386724, 37047287 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 31558772
★☆☆☆☆
Found in Text Mining only
Chronic Obstructive Airway Disease Chronic Obstructive Pulmonary Disease BEFREE 26752192
★☆☆☆☆
Found in Text Mining only