Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10175
Gene name	Cornichon family member 1
Gene symbol	CNIH1
Synonyms (NCBI Gene)	CNIHCNIH-1CNILTGAM77
Chromosome	14
Chromosome location	14q22.2

147

Show/Hide all (147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT341538	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT341535	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT341534	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT341537	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT507715	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT507714	hsa-miR-759	PAR-CLIP	20371350
MIRT507710	hsa-miR-4509	PAR-CLIP	20371350
MIRT507709	hsa-miR-5701	PAR-CLIP	20371350
MIRT070408	hsa-miR-7703	PAR-CLIP	20371350
MIRT070402	hsa-miR-4325	PAR-CLIP	20371350
MIRT507708	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT341538	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT341535	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT341534	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT341537	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT507715	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT507714	hsa-miR-759	PAR-CLIP	20371350
MIRT507710	hsa-miR-4509	PAR-CLIP	20371350
MIRT507709	hsa-miR-5701	PAR-CLIP	20371350
MIRT070408	hsa-miR-7703	PAR-CLIP	20371350
MIRT070402	hsa-miR-4325	PAR-CLIP	20371350
MIRT507708	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT558680	hsa-miR-548ac	PAR-CLIP	21572407
MIRT558679	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT558678	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT558677	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT558676	hsa-miR-548z	PAR-CLIP	21572407
MIRT558675	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT558674	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT558673	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT558672	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT558671	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT558670	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT558669	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT558668	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT558667	hsa-miR-600	PAR-CLIP	21572407
MIRT558666	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT558665	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT341538	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT341535	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT341534	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT341537	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT507715	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT507714	hsa-miR-759	PAR-CLIP	21572407
MIRT507710	hsa-miR-4509	PAR-CLIP	21572407
MIRT507709	hsa-miR-5701	PAR-CLIP	21572407
MIRT070408	hsa-miR-7703	PAR-CLIP	21572407
MIRT070402	hsa-miR-4325	PAR-CLIP	21572407
MIRT507708	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT341538	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT341535	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT341534	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT341537	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT507716	hsa-miR-6165	PAR-CLIP	23446348
MIRT507715	hsa-miR-205-3p	PAR-CLIP	23446348
MIRT507714	hsa-miR-759	PAR-CLIP	23446348
MIRT507713	hsa-miR-214-3p	PAR-CLIP	23446348
MIRT507712	hsa-miR-3619-5p	PAR-CLIP	23446348
MIRT507711	hsa-miR-761	PAR-CLIP	23446348
MIRT507710	hsa-miR-4509	PAR-CLIP	23446348
MIRT507709	hsa-miR-5701	PAR-CLIP	23446348
MIRT070408	hsa-miR-7703	PAR-CLIP	23446348
MIRT070402	hsa-miR-4325	PAR-CLIP	23446348
MIRT507708	hsa-miR-3942-3p	PAR-CLIP	23446348
MIRT341536	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT341540	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT341535	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT341538	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT341535	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT341534	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT341537	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT753764	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT753765	hsa-miR-759	PAR-CLIP	20371350
MIRT753766	hsa-miR-4509	PAR-CLIP	20371350
MIRT753767	hsa-miR-5701	PAR-CLIP	20371350
MIRT070408	hsa-miR-7703	PAR-CLIP	20371350
MIRT070402	hsa-miR-4325	PAR-CLIP	20371350
MIRT753768	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT341538	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT341535	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT341534	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT341537	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT753764	hsa-miR-205-3p	PAR-CLIP	20371350
MIRT753765	hsa-miR-759	PAR-CLIP	20371350
MIRT753766	hsa-miR-4509	PAR-CLIP	20371350
MIRT753767	hsa-miR-5701	PAR-CLIP	20371350
MIRT070408	hsa-miR-7703	PAR-CLIP	20371350
MIRT070402	hsa-miR-4325	PAR-CLIP	20371350
MIRT753768	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT754209	hsa-miR-548ac	PAR-CLIP	21572407
MIRT754210	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT754211	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT754212	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT754213	hsa-miR-548z	PAR-CLIP	21572407
MIRT754214	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT754215	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT754216	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT754217	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT754218	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT754219	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT754220	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT754221	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT754222	hsa-miR-600	PAR-CLIP	21572407
MIRT754223	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT754224	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT341538	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT341535	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT341534	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT341537	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT753764	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT753765	hsa-miR-759	PAR-CLIP	21572407
MIRT753766	hsa-miR-4509	PAR-CLIP	21572407
MIRT753767	hsa-miR-5701	PAR-CLIP	21572407
MIRT070408	hsa-miR-7703	PAR-CLIP	21572407
MIRT070402	hsa-miR-4325	PAR-CLIP	21572407
MIRT753768	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT341538	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT341535	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT341540	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT341536	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT341534	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT341537	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT754697	hsa-miR-6165	PAR-CLIP	23446348
MIRT753764	hsa-miR-205-3p	PAR-CLIP	23446348
MIRT753765	hsa-miR-759	PAR-CLIP	23446348
MIRT754698	hsa-miR-214-3p	PAR-CLIP	23446348
MIRT754699	hsa-miR-3619-5p	PAR-CLIP	23446348
MIRT754700	hsa-miR-761	PAR-CLIP	23446348
MIRT753766	hsa-miR-4509	PAR-CLIP	23446348
MIRT753767	hsa-miR-5701	PAR-CLIP	23446348
MIRT070408	hsa-miR-7703	PAR-CLIP	23446348
MIRT070402	hsa-miR-4325	PAR-CLIP	23446348
MIRT753768	hsa-miR-3942-3p	PAR-CLIP	23446348

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006955	Process	Immune response	TAS	10209299
GO:0007165	Process	Signal transduction	TAS	10209299
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS

MIM	HGNC	e!Ensembl
611287	19431	ENSG00000100528

O95406

Protein name

Protein cornichon homolog 1 (CNIH-1) (Cornichon family AMPA receptor auxiliary protein 1) (Protein cornichon homolog) (T-cell growth-associated molecule 77) (TGAM77)

Protein function

Involved in the selective transport and maturation of TGF-alpha family proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03311	Cornichon	7 → 135	Cornichon protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, s

Sequence

MAFTFAAFCYMLALLLTAALIFFAIWHIIAFDELKTDYKNPIDQCNTLNPLVLPEYLIHA
FFCVMFLCAAEWLTLGLNMPLLAYHIWRYMSRPVMSGPGLYDPTTIMNADILAYCQKEGW
CKLAFYLLAFFYYLYGMIYVLVSS

Sequence length

144

Interactions

View interactions

	Reactome
			COPII-mediated vesicle transport Cargo concentration in the ER

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CNIH1 (cornichon family member 1)