TOB1 (transducer of ERBB2, 1)

Gene

• Entrez ID: 10140
• Gene name: Transducer of ERBB2, 1
• Gene symbol: TOB1
• Synonyms (NCBI Gene): APRO5, APRO6, PIG49, TOB, TROB, TROB1
• Chromosome: 17
• Chromosome location: 17q21.33
• Summary: This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007049	hsa-miR-218-5p	Luciferase reporter assay	23060446
MIRT050970	hsa-miR-17-5p	CLASH	23622248
MIRT039574	hsa-miR-641	CLASH	23622248
MIRT077897	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT077898	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT077902	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT077903	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT542628	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	20371350
MIRT533591	hsa-miR-5697	PAR-CLIP	20371350
MIRT533590	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT533589	hsa-miR-1297	PAR-CLIP	20371350
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT533586	hsa-miR-4465	PAR-CLIP	20371350
MIRT533585	hsa-miR-498	PAR-CLIP	20371350
MIRT533584	hsa-miR-1305	PAR-CLIP	20371350
MIRT288031	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT077897	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT077898	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT077902	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT077903	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542628	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT533591	hsa-miR-5697	PAR-CLIP	21572407
MIRT533590	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT533589	hsa-miR-1297	PAR-CLIP	21572407
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT533586	hsa-miR-4465	PAR-CLIP	21572407
MIRT533585	hsa-miR-498	PAR-CLIP	21572407
MIRT533584	hsa-miR-1305	PAR-CLIP	21572407
MIRT288031	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT077897	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT077898	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT077902	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT077903	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542628	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT533591	hsa-miR-5697	PAR-CLIP	21572407
MIRT533590	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT533589	hsa-miR-1297	PAR-CLIP	21572407
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT533586	hsa-miR-4465	PAR-CLIP	21572407
MIRT533585	hsa-miR-498	PAR-CLIP	21572407
MIRT533584	hsa-miR-1305	PAR-CLIP	21572407
MIRT288031	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT077897	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT077898	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT077902	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT077903	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT533591	hsa-miR-5697	PAR-CLIP	22012620
MIRT533590	hsa-miR-889-3p	PAR-CLIP	22012620
MIRT533589	hsa-miR-1297	PAR-CLIP	22012620
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT533586	hsa-miR-4465	PAR-CLIP	22012620
MIRT533585	hsa-miR-498	PAR-CLIP	22012620
MIRT533584	hsa-miR-1305	PAR-CLIP	22012620
MIRT288031	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT007049	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT007049	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT533588	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT533587	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT077900	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT077904	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT077898	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT007049	hsa-miR-218-5p	Microarray, qRT-PCR, Western blot	26540468
MIRT735801	hsa-miR-486-5p	Luciferase reporter assay, qRT-PCR	32406432
MIRT077897	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT077898	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT077902	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT077903	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT542628	hsa-miR-338-5p	PAR-CLIP	20371350
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	20371350
MIRT533591	hsa-miR-5697	PAR-CLIP	20371350
MIRT533590	hsa-miR-889-3p	PAR-CLIP	20371350
MIRT533589	hsa-miR-1297	PAR-CLIP	20371350
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT533586	hsa-miR-4465	PAR-CLIP	20371350
MIRT533585	hsa-miR-498	PAR-CLIP	20371350
MIRT533584	hsa-miR-1305	PAR-CLIP	20371350
MIRT288031	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT077897	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT077898	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT077902	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT077903	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542628	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT533591	hsa-miR-5697	PAR-CLIP	21572407
MIRT533590	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT533589	hsa-miR-1297	PAR-CLIP	21572407
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT533586	hsa-miR-4465	PAR-CLIP	21572407
MIRT533585	hsa-miR-498	PAR-CLIP	21572407
MIRT533584	hsa-miR-1305	PAR-CLIP	21572407
MIRT288031	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT077897	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT077898	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT077902	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT077903	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542628	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT533591	hsa-miR-5697	PAR-CLIP	21572407
MIRT533590	hsa-miR-889-3p	PAR-CLIP	21572407
MIRT533589	hsa-miR-1297	PAR-CLIP	21572407
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT533586	hsa-miR-4465	PAR-CLIP	21572407
MIRT533585	hsa-miR-498	PAR-CLIP	21572407
MIRT533584	hsa-miR-1305	PAR-CLIP	21572407
MIRT288031	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT077897	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT077898	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT077902	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT077903	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT077900	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT077904	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT533592	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT533591	hsa-miR-5697	PAR-CLIP	22012620
MIRT533590	hsa-miR-889-3p	PAR-CLIP	22012620
MIRT533589	hsa-miR-1297	PAR-CLIP	22012620
MIRT533588	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT533587	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT533586	hsa-miR-4465	PAR-CLIP	22012620
MIRT533585	hsa-miR-498	PAR-CLIP	22012620
MIRT533584	hsa-miR-1305	PAR-CLIP	22012620
MIRT288031	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT1445820	hsa-miR-129-5p	CLIP-seq
MIRT1445821	hsa-miR-182	CLIP-seq
MIRT1445822	hsa-miR-1910	CLIP-seq
MIRT1445823	hsa-miR-1973	CLIP-seq
MIRT1445824	hsa-miR-200b	CLIP-seq
MIRT1445825	hsa-miR-200c	CLIP-seq
MIRT1445826	hsa-miR-2113	CLIP-seq
MIRT1445827	hsa-miR-2114	CLIP-seq
MIRT1445828	hsa-miR-218	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445832	hsa-miR-2964a-5p	CLIP-seq
MIRT1445833	hsa-miR-296-5p	CLIP-seq
MIRT1445834	hsa-miR-300	CLIP-seq
MIRT1445835	hsa-miR-3134	CLIP-seq
MIRT1445836	hsa-miR-3143	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445838	hsa-miR-3145-3p	CLIP-seq
MIRT1445839	hsa-miR-3157-5p	CLIP-seq
MIRT1445840	hsa-miR-3163	CLIP-seq
MIRT1445841	hsa-miR-3189-3p	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445843	hsa-miR-3200-5p	CLIP-seq
MIRT1445844	hsa-miR-3201	CLIP-seq
MIRT1445845	hsa-miR-340	CLIP-seq
MIRT1445846	hsa-miR-345	CLIP-seq
MIRT1445847	hsa-miR-3617	CLIP-seq
MIRT1445848	hsa-miR-362-5p	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445850	hsa-miR-3646	CLIP-seq
MIRT1445851	hsa-miR-3658	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445853	hsa-miR-3713	CLIP-seq
MIRT1445854	hsa-miR-371-3p	CLIP-seq
MIRT1445855	hsa-miR-371b-3p	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT1445857	hsa-miR-381	CLIP-seq
MIRT1445858	hsa-miR-4251	CLIP-seq
MIRT1445859	hsa-miR-429	CLIP-seq
MIRT1445860	hsa-miR-4307	CLIP-seq
MIRT1445861	hsa-miR-4329	CLIP-seq
MIRT1445862	hsa-miR-4426	CLIP-seq
MIRT1445863	hsa-miR-4470	CLIP-seq
MIRT1445864	hsa-miR-4473	CLIP-seq
MIRT1445865	hsa-miR-4509	CLIP-seq
MIRT1445866	hsa-miR-455-3p	CLIP-seq
MIRT1445867	hsa-miR-4647	CLIP-seq
MIRT1445868	hsa-miR-4659a-3p	CLIP-seq
MIRT1445869	hsa-miR-4659b-3p	CLIP-seq
MIRT1445870	hsa-miR-4662b	CLIP-seq
MIRT1445871	hsa-miR-4666-3p	CLIP-seq
MIRT1445872	hsa-miR-4668-3p	CLIP-seq
MIRT1445873	hsa-miR-4671-3p	CLIP-seq
MIRT1445874	hsa-miR-4691-3p	CLIP-seq
MIRT1445875	hsa-miR-4693-3p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445877	hsa-miR-4731-3p	CLIP-seq
MIRT1445878	hsa-miR-4789-5p	CLIP-seq
MIRT1445879	hsa-miR-4791	CLIP-seq
MIRT1445880	hsa-miR-4795-3p	CLIP-seq
MIRT1445881	hsa-miR-4801	CLIP-seq
MIRT1445882	hsa-miR-500b	CLIP-seq
MIRT1445883	hsa-miR-501-5p	CLIP-seq
MIRT1445884	hsa-miR-502-5p	CLIP-seq
MIRT1445885	hsa-miR-511	CLIP-seq
MIRT1445886	hsa-miR-515-3p	CLIP-seq
MIRT1445887	hsa-miR-517b	CLIP-seq
MIRT1445888	hsa-miR-519e	CLIP-seq
MIRT1445889	hsa-miR-520d-5p	CLIP-seq
MIRT1445890	hsa-miR-524-5p	CLIP-seq
MIRT1445891	hsa-miR-548c-3p	CLIP-seq
MIRT1445892	hsa-miR-548p	CLIP-seq
MIRT1445893	hsa-miR-587	CLIP-seq
MIRT1445894	hsa-miR-605	CLIP-seq
MIRT1445895	hsa-miR-626	CLIP-seq
MIRT1445896	hsa-miR-635	CLIP-seq
MIRT1445897	hsa-miR-636	CLIP-seq
MIRT1445898	hsa-miR-642a	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445900	hsa-miR-889	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT1445820	hsa-miR-129-5p	CLIP-seq
MIRT1445821	hsa-miR-182	CLIP-seq
MIRT1445822	hsa-miR-1910	CLIP-seq
MIRT1445824	hsa-miR-200b	CLIP-seq
MIRT1445825	hsa-miR-200c	CLIP-seq
MIRT1445826	hsa-miR-2113	CLIP-seq
MIRT1445827	hsa-miR-2114	CLIP-seq
MIRT1445828	hsa-miR-218	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445832	hsa-miR-2964a-5p	CLIP-seq
MIRT1445835	hsa-miR-3134	CLIP-seq
MIRT1445836	hsa-miR-3143	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445838	hsa-miR-3145-3p	CLIP-seq
MIRT1445839	hsa-miR-3157-5p	CLIP-seq
MIRT1445840	hsa-miR-3163	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445843	hsa-miR-3200-5p	CLIP-seq
MIRT1445844	hsa-miR-3201	CLIP-seq
MIRT1445845	hsa-miR-340	CLIP-seq
MIRT1445846	hsa-miR-345	CLIP-seq
MIRT1445847	hsa-miR-3617	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445850	hsa-miR-3646	CLIP-seq
MIRT1445851	hsa-miR-3658	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT1445858	hsa-miR-4251	CLIP-seq
MIRT1445859	hsa-miR-429	CLIP-seq
MIRT1445861	hsa-miR-4329	CLIP-seq
MIRT1445862	hsa-miR-4426	CLIP-seq
MIRT1445863	hsa-miR-4470	CLIP-seq
MIRT1445865	hsa-miR-4509	CLIP-seq
MIRT1445866	hsa-miR-455-3p	CLIP-seq
MIRT1445867	hsa-miR-4647	CLIP-seq
MIRT1445868	hsa-miR-4659a-3p	CLIP-seq
MIRT1445869	hsa-miR-4659b-3p	CLIP-seq
MIRT1445870	hsa-miR-4662b	CLIP-seq
MIRT1445874	hsa-miR-4691-3p	CLIP-seq
MIRT1445875	hsa-miR-4693-3p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445877	hsa-miR-4731-3p	CLIP-seq
MIRT1445879	hsa-miR-4791	CLIP-seq
MIRT1445881	hsa-miR-4801	CLIP-seq
MIRT1445884	hsa-miR-502-5p	CLIP-seq
MIRT1445885	hsa-miR-511	CLIP-seq
MIRT1445889	hsa-miR-520d-5p	CLIP-seq
MIRT1445890	hsa-miR-524-5p	CLIP-seq
MIRT1445891	hsa-miR-548c-3p	CLIP-seq
MIRT1445892	hsa-miR-548p	CLIP-seq
MIRT1445893	hsa-miR-587	CLIP-seq
MIRT1445897	hsa-miR-636	CLIP-seq
MIRT1445898	hsa-miR-642a	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445900	hsa-miR-889	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT2354497	hsa-miR-127-5p	CLIP-seq
MIRT1445821	hsa-miR-182	CLIP-seq
MIRT1445822	hsa-miR-1910	CLIP-seq
MIRT1445823	hsa-miR-1973	CLIP-seq
MIRT1445824	hsa-miR-200b	CLIP-seq
MIRT1445825	hsa-miR-200c	CLIP-seq
MIRT1445826	hsa-miR-2113	CLIP-seq
MIRT1445827	hsa-miR-2114	CLIP-seq
MIRT1445828	hsa-miR-218	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445832	hsa-miR-2964a-5p	CLIP-seq
MIRT1445833	hsa-miR-296-5p	CLIP-seq
MIRT1445835	hsa-miR-3134	CLIP-seq
MIRT1445836	hsa-miR-3143	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445838	hsa-miR-3145-3p	CLIP-seq
MIRT1445839	hsa-miR-3157-5p	CLIP-seq
MIRT1445840	hsa-miR-3163	CLIP-seq
MIRT1445841	hsa-miR-3189-3p	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445843	hsa-miR-3200-5p	CLIP-seq
MIRT1445844	hsa-miR-3201	CLIP-seq
MIRT1445845	hsa-miR-340	CLIP-seq
MIRT1445846	hsa-miR-345	CLIP-seq
MIRT1445847	hsa-miR-3617	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445850	hsa-miR-3646	CLIP-seq
MIRT1445851	hsa-miR-3658	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445854	hsa-miR-371-3p	CLIP-seq
MIRT1445855	hsa-miR-371b-3p	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT2354498	hsa-miR-374c	CLIP-seq
MIRT1445858	hsa-miR-4251	CLIP-seq
MIRT1445859	hsa-miR-429	CLIP-seq
MIRT1445861	hsa-miR-4329	CLIP-seq
MIRT1445862	hsa-miR-4426	CLIP-seq
MIRT1445863	hsa-miR-4470	CLIP-seq
MIRT1445864	hsa-miR-4473	CLIP-seq
MIRT1445865	hsa-miR-4509	CLIP-seq
MIRT1445866	hsa-miR-455-3p	CLIP-seq
MIRT1445867	hsa-miR-4647	CLIP-seq
MIRT1445868	hsa-miR-4659a-3p	CLIP-seq
MIRT1445869	hsa-miR-4659b-3p	CLIP-seq
MIRT1445870	hsa-miR-4662b	CLIP-seq
MIRT1445872	hsa-miR-4668-3p	CLIP-seq
MIRT1445873	hsa-miR-4671-3p	CLIP-seq
MIRT1445874	hsa-miR-4691-3p	CLIP-seq
MIRT1445875	hsa-miR-4693-3p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445877	hsa-miR-4731-3p	CLIP-seq
MIRT1445879	hsa-miR-4791	CLIP-seq
MIRT1445881	hsa-miR-4801	CLIP-seq
MIRT1445884	hsa-miR-502-5p	CLIP-seq
MIRT1445885	hsa-miR-511	CLIP-seq
MIRT1445886	hsa-miR-515-3p	CLIP-seq
MIRT1445887	hsa-miR-517b	CLIP-seq
MIRT1445888	hsa-miR-519e	CLIP-seq
MIRT1445891	hsa-miR-548c-3p	CLIP-seq
MIRT1445893	hsa-miR-587	CLIP-seq
MIRT2354499	hsa-miR-590-3p	CLIP-seq
MIRT1445894	hsa-miR-605	CLIP-seq
MIRT1445895	hsa-miR-626	CLIP-seq
MIRT1445896	hsa-miR-635	CLIP-seq
MIRT1445897	hsa-miR-636	CLIP-seq
MIRT1445898	hsa-miR-642a	CLIP-seq
MIRT2354500	hsa-miR-655	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445900	hsa-miR-889	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT1445820	hsa-miR-129-5p	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445834	hsa-miR-300	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445838	hsa-miR-3145-3p	CLIP-seq
MIRT1445839	hsa-miR-3157-5p	CLIP-seq
MIRT1445840	hsa-miR-3163	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445845	hsa-miR-340	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445854	hsa-miR-371-3p	CLIP-seq
MIRT1445855	hsa-miR-371b-3p	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT1445857	hsa-miR-381	CLIP-seq
MIRT1445864	hsa-miR-4473	CLIP-seq
MIRT1445868	hsa-miR-4659a-3p	CLIP-seq
MIRT1445869	hsa-miR-4659b-3p	CLIP-seq
MIRT1445871	hsa-miR-4666-3p	CLIP-seq
MIRT1445873	hsa-miR-4671-3p	CLIP-seq
MIRT1445874	hsa-miR-4691-3p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445878	hsa-miR-4789-5p	CLIP-seq
MIRT1445884	hsa-miR-502-5p	CLIP-seq
MIRT1445886	hsa-miR-515-3p	CLIP-seq
MIRT1445888	hsa-miR-519e	CLIP-seq
MIRT1445889	hsa-miR-520d-5p	CLIP-seq
MIRT1445890	hsa-miR-524-5p	CLIP-seq
MIRT1445891	hsa-miR-548c-3p	CLIP-seq
MIRT1445892	hsa-miR-548p	CLIP-seq
MIRT1445893	hsa-miR-587	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445900	hsa-miR-889	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq
MIRT1445818	hsa-miR-1183	CLIP-seq
MIRT1445819	hsa-miR-1208	CLIP-seq
MIRT1445820	hsa-miR-129-5p	CLIP-seq
MIRT2693849	hsa-miR-1322	CLIP-seq
MIRT1445821	hsa-miR-182	CLIP-seq
MIRT1445824	hsa-miR-200b	CLIP-seq
MIRT1445825	hsa-miR-200c	CLIP-seq
MIRT1445826	hsa-miR-2113	CLIP-seq
MIRT1445828	hsa-miR-218	CLIP-seq
MIRT1445829	hsa-miR-25	CLIP-seq
MIRT1445830	hsa-miR-26a	CLIP-seq
MIRT1445831	hsa-miR-26b	CLIP-seq
MIRT1445834	hsa-miR-300	CLIP-seq
MIRT1445837	hsa-miR-3144-3p	CLIP-seq
MIRT1445838	hsa-miR-3145-3p	CLIP-seq
MIRT1445839	hsa-miR-3157-5p	CLIP-seq
MIRT1445840	hsa-miR-3163	CLIP-seq
MIRT1445842	hsa-miR-32	CLIP-seq
MIRT1445845	hsa-miR-340	CLIP-seq
MIRT1445848	hsa-miR-362-5p	CLIP-seq
MIRT1445849	hsa-miR-363	CLIP-seq
MIRT1445850	hsa-miR-3646	CLIP-seq
MIRT2693850	hsa-miR-3662	CLIP-seq
MIRT1445852	hsa-miR-367	CLIP-seq
MIRT1445853	hsa-miR-3713	CLIP-seq
MIRT1445854	hsa-miR-371-3p	CLIP-seq
MIRT1445855	hsa-miR-371b-3p	CLIP-seq
MIRT1445856	hsa-miR-371b-5p	CLIP-seq
MIRT1445857	hsa-miR-381	CLIP-seq
MIRT1445859	hsa-miR-429	CLIP-seq
MIRT1445860	hsa-miR-4307	CLIP-seq
MIRT1445863	hsa-miR-4470	CLIP-seq
MIRT1445864	hsa-miR-4473	CLIP-seq
MIRT1445868	hsa-miR-4659a-3p	CLIP-seq
MIRT1445869	hsa-miR-4659b-3p	CLIP-seq
MIRT1445871	hsa-miR-4666-3p	CLIP-seq
MIRT1445873	hsa-miR-4671-3p	CLIP-seq
MIRT1445874	hsa-miR-4691-3p	CLIP-seq
MIRT1445875	hsa-miR-4693-3p	CLIP-seq
MIRT1445876	hsa-miR-4698	CLIP-seq
MIRT1445878	hsa-miR-4789-5p	CLIP-seq
MIRT1445880	hsa-miR-4795-3p	CLIP-seq
MIRT1445882	hsa-miR-500b	CLIP-seq
MIRT1445883	hsa-miR-501-5p	CLIP-seq
MIRT1445884	hsa-miR-502-5p	CLIP-seq
MIRT1445886	hsa-miR-515-3p	CLIP-seq
MIRT1445888	hsa-miR-519e	CLIP-seq
MIRT1445889	hsa-miR-520d-5p	CLIP-seq
MIRT1445890	hsa-miR-524-5p	CLIP-seq
MIRT1445891	hsa-miR-548c-3p	CLIP-seq
MIRT1445892	hsa-miR-548p	CLIP-seq
MIRT1445893	hsa-miR-587	CLIP-seq
MIRT1445897	hsa-miR-636	CLIP-seq
MIRT1445899	hsa-miR-888	CLIP-seq
MIRT1445900	hsa-miR-889	CLIP-seq
MIRT1445901	hsa-miR-92a	CLIP-seq
MIRT1445902	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0005515	Function	Protein binding	IPI	18377426, 19276069, 20595394, 21336257, 26496610, 28514442, 31515488, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	8632892, 19276069
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	8632892
GO:0010468	Process	Regulation of gene expression	IBA
GO:0017148	Process	Negative regulation of translation	IDA	23236473
GO:0030014	Component	CCR4-NOT complex	IDA	21336257
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IDA	8632892
GO:0045668	Process	Negative regulation of osteoblast differentiation	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046332	Function	SMAD binding	IEA
GO:0060212	Process	Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA	18377426
GO:0060213	Process	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA	21336257
GO:0060390	Process	Regulation of SMAD protein signal transduction	IEA
GO:1900153	Process	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA	21336257

Other IDs

• MIM: 605523
• HGNC: 11979
• e!Ensembl: ENSG00000141232

Protein

• UniProt ID: P50616
• Protein name: Protein Tob1 (Transducer of erbB-2 1)
• Protein function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which
• PDB: 2D5R, 2Z15, 5CI8, 5CI9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07742	BTG	1 → 112	BTG family	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHI
  GEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNEN
  GCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTA
  TFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQP
  QQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSP
  LQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

• Sequence length: 345

Pathways

KEGG:

RNA degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHLORACNE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autoimmune Diseases	Autoimmune Diseases	BEFREE	23797093		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17883950, 19491269, 26165839, 28922388		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20132413, 26165839, 28922388, 33173433, 33786619, 40169858	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22710759	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22158108, 23467607		★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Cartilage disease	Pubtator	15743474	Associate	★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	BEFREE	15743474		★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	Pubtator	15743474	Inhibit	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30447686		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	33247598	Associate	★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating Diseases	BEFREE	23797093		★☆☆☆☆ Found in Text Mining only
Endometrioma	Endometrioma	CTD_human_DG	21063030		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	21063030		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma	Glioblastoma	Pubtator	39652629	Associate	★☆☆☆☆ Found in Text Mining only
Hemoglobinuria Paroxysmal	Hemoglobinuria paroxysmal	Pubtator	28630090	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	33247598	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	14643028		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	22158108	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17883950, 19491269, 26165839, 28922388		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22158108, 23467607		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21533545, 22710759, 25043310, 25760308, 26572149, 29088861, 30962003, 31497236		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18657378, 22158108, 22710759, 26694352		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30447686		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	16049915		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	28494871		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	18689680, 23797093, 28947212		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	18689680	Associate	★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	24144310		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18657378, 22158108, 25405282, 26165839, 26609221, 26694352, 29088861, 30447686, 30529155, 31772627		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11423116		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	11423116	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31772627		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	28494871, 31118946		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	22543871		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	38494731	Stimulate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31891232	Inhibit	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	37753069	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	22710759, 25043310, 25760308, 26572149, 29088861, 30962003, 31497236		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	21533545, 26572149, 35465266	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22710759, 35186488	Inhibit	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	36917092	Associate	★☆☆☆☆ Found in Text Mining only