YAF2 (YY1 associated factor 2)

Gene

• Entrez ID: 10138
• Gene name: YY1 associated factor 2
• Gene symbol: YAF2
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q12
• Summary: This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027053	hsa-miR-103a-3p	Sequencing	20371350
MIRT552804	hsa-miR-107	PAR-CLIP	21572407
MIRT027053	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT552803	hsa-miR-548ac	PAR-CLIP	21572407
MIRT552802	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT552801	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT552800	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT552799	hsa-miR-548z	PAR-CLIP	21572407
MIRT552798	hsa-miR-649	PAR-CLIP	21572407
MIRT552797	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT552796	hsa-miR-382-5p	PAR-CLIP	21572407
MIRT552795	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT552794	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT552793	hsa-miR-367-5p	PAR-CLIP	21572407
MIRT552792	hsa-miR-2116-5p	PAR-CLIP	21572407
MIRT552791	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT552790	hsa-miR-4684-3p	PAR-CLIP	21572407
MIRT552789	hsa-miR-6844	PAR-CLIP	21572407
MIRT552788	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT552787	hsa-miR-5047	PAR-CLIP	21572407
MIRT552785	hsa-miR-4273	PAR-CLIP	21572407
MIRT552786	hsa-miR-7156-5p	PAR-CLIP	21572407
MIRT552784	hsa-miR-4677-5p	PAR-CLIP	21572407
MIRT552783	hsa-miR-6739-3p	PAR-CLIP	21572407
MIRT520094	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT064656	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520093	hsa-miR-6074	PAR-CLIP	21572407
MIRT520092	hsa-miR-4272	PAR-CLIP	21572407
MIRT064648	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT520091	hsa-miR-3924	PAR-CLIP	21572407
MIRT520090	hsa-miR-3671	PAR-CLIP	21572407
MIRT520087	hsa-miR-607	PAR-CLIP	21572407
MIRT064651	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520094	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT064656	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520093	hsa-miR-6074	PAR-CLIP	23446348
MIRT520092	hsa-miR-4272	PAR-CLIP	23446348
MIRT064648	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT520091	hsa-miR-3924	PAR-CLIP	23446348
MIRT520090	hsa-miR-3671	PAR-CLIP	23446348
MIRT520089	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT520088	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT520087	hsa-miR-607	PAR-CLIP	23446348
MIRT520086	hsa-miR-335-3p	PAR-CLIP	23446348
MIRT064651	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT552804	hsa-miR-107	PAR-CLIP	21572407
MIRT027053	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT552803	hsa-miR-548ac	PAR-CLIP	21572407
MIRT552802	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT552801	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT552800	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT552799	hsa-miR-548z	PAR-CLIP	21572407
MIRT552798	hsa-miR-649	PAR-CLIP	21572407
MIRT552797	hsa-miR-495-5p	PAR-CLIP	21572407
MIRT552796	hsa-miR-382-5p	PAR-CLIP	21572407
MIRT552795	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT552794	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT552793	hsa-miR-367-5p	PAR-CLIP	21572407
MIRT552792	hsa-miR-2116-5p	PAR-CLIP	21572407
MIRT552791	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT552790	hsa-miR-4684-3p	PAR-CLIP	21572407
MIRT552789	hsa-miR-6844	PAR-CLIP	21572407
MIRT552788	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT552787	hsa-miR-5047	PAR-CLIP	21572407
MIRT552785	hsa-miR-4273	PAR-CLIP	21572407
MIRT552786	hsa-miR-7156-5p	PAR-CLIP	21572407
MIRT552784	hsa-miR-4677-5p	PAR-CLIP	21572407
MIRT552783	hsa-miR-6739-3p	PAR-CLIP	21572407
MIRT520094	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT064656	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520093	hsa-miR-6074	PAR-CLIP	21572407
MIRT520092	hsa-miR-4272	PAR-CLIP	21572407
MIRT064648	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT520091	hsa-miR-3924	PAR-CLIP	21572407
MIRT520090	hsa-miR-3671	PAR-CLIP	21572407
MIRT520087	hsa-miR-607	PAR-CLIP	21572407
MIRT064651	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520094	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT064656	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520093	hsa-miR-6074	PAR-CLIP	23446348
MIRT520092	hsa-miR-4272	PAR-CLIP	23446348
MIRT064648	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT520091	hsa-miR-3924	PAR-CLIP	23446348
MIRT520090	hsa-miR-3671	PAR-CLIP	23446348
MIRT520089	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT520088	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT520087	hsa-miR-607	PAR-CLIP	23446348
MIRT520086	hsa-miR-335-3p	PAR-CLIP	23446348
MIRT064651	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1497968	hsa-miR-141	CLIP-seq
MIRT1497969	hsa-miR-200a	CLIP-seq
MIRT1497970	hsa-miR-217	CLIP-seq
MIRT1497971	hsa-miR-2682	CLIP-seq
MIRT1497972	hsa-miR-3150b-3p	CLIP-seq
MIRT1497973	hsa-miR-3616-3p	CLIP-seq
MIRT1497974	hsa-miR-369-3p	CLIP-seq
MIRT1497975	hsa-miR-371-5p	CLIP-seq
MIRT1497976	hsa-miR-371b-5p	CLIP-seq
MIRT1497977	hsa-miR-374c	CLIP-seq
MIRT1497978	hsa-miR-3925-5p	CLIP-seq
MIRT1497979	hsa-miR-4311	CLIP-seq
MIRT1497980	hsa-miR-4423-3p	CLIP-seq
MIRT1497981	hsa-miR-449c	CLIP-seq
MIRT1497982	hsa-miR-4689	CLIP-seq
MIRT1497983	hsa-miR-4731-3p	CLIP-seq
MIRT1497984	hsa-miR-4773	CLIP-seq
MIRT1497985	hsa-miR-4779	CLIP-seq
MIRT1497986	hsa-miR-4784	CLIP-seq
MIRT1497987	hsa-miR-4801	CLIP-seq
MIRT1497988	hsa-miR-655	CLIP-seq
MIRT1497989	hsa-miR-940	CLIP-seq
MIRT1497990	hsa-miR-1253	CLIP-seq
MIRT1497991	hsa-miR-1271	CLIP-seq
MIRT1497992	hsa-miR-1273	CLIP-seq
MIRT1497993	hsa-miR-150	CLIP-seq
MIRT1497994	hsa-miR-182	CLIP-seq
MIRT1497995	hsa-miR-1827	CLIP-seq
MIRT1497996	hsa-miR-18a	CLIP-seq
MIRT1497997	hsa-miR-18b	CLIP-seq
MIRT1497998	hsa-miR-210	CLIP-seq
MIRT1497999	hsa-miR-24	CLIP-seq
MIRT1498000	hsa-miR-3123	CLIP-seq
MIRT1498001	hsa-miR-3143	CLIP-seq
MIRT1498002	hsa-miR-3145-5p	CLIP-seq
MIRT1498003	hsa-miR-337-3p	CLIP-seq
MIRT1498004	hsa-miR-340	CLIP-seq
MIRT1498005	hsa-miR-3614-5p	CLIP-seq
MIRT1498006	hsa-miR-3919	CLIP-seq
MIRT1498007	hsa-miR-3974	CLIP-seq
MIRT1498008	hsa-miR-4252	CLIP-seq
MIRT1498009	hsa-miR-4256	CLIP-seq
MIRT1498010	hsa-miR-4266	CLIP-seq
MIRT1498011	hsa-miR-4277	CLIP-seq
MIRT1498012	hsa-miR-4284	CLIP-seq
MIRT1497979	hsa-miR-4311	CLIP-seq
MIRT1498013	hsa-miR-4421	CLIP-seq
MIRT1498014	hsa-miR-4486	CLIP-seq
MIRT1498015	hsa-miR-4649-5p	CLIP-seq
MIRT1498016	hsa-miR-4695-5p	CLIP-seq
MIRT1498017	hsa-miR-4735-3p	CLIP-seq
MIRT1498018	hsa-miR-4756-3p	CLIP-seq
MIRT1498019	hsa-miR-4761-5p	CLIP-seq
MIRT1498020	hsa-miR-4762-5p	CLIP-seq
MIRT1498021	hsa-miR-4774-5p	CLIP-seq
MIRT1497985	hsa-miR-4779	CLIP-seq
MIRT1498022	hsa-miR-488	CLIP-seq
MIRT1498023	hsa-miR-508-5p	CLIP-seq
MIRT1498024	hsa-miR-543	CLIP-seq
MIRT1498025	hsa-miR-605	CLIP-seq
MIRT1498026	hsa-miR-622	CLIP-seq
MIRT1498027	hsa-miR-661	CLIP-seq
MIRT1498028	hsa-miR-766	CLIP-seq
MIRT1498029	hsa-miR-935	CLIP-seq
MIRT1498030	hsa-miR-96	CLIP-seq
MIRT1498031	hsa-miR-1183	CLIP-seq
MIRT1498032	hsa-miR-34b	CLIP-seq
MIRT1498033	hsa-miR-4693-5p	CLIP-seq
MIRT1498034	hsa-miR-499a-5p	CLIP-seq
MIRT1555652	hsa-miR-3689a-3p	CLIP-seq
MIRT1555653	hsa-miR-3689c	CLIP-seq
MIRT1555654	hsa-miR-4728-5p	CLIP-seq
MIRT2150042	hsa-miR-122	CLIP-seq
MIRT2150043	hsa-miR-1273e	CLIP-seq
MIRT2150044	hsa-miR-1297	CLIP-seq
MIRT2150045	hsa-miR-140-3p	CLIP-seq
MIRT1497995	hsa-miR-1827	CLIP-seq
MIRT2150046	hsa-miR-26a	CLIP-seq
MIRT2150047	hsa-miR-26b	CLIP-seq
MIRT2150048	hsa-miR-2964a-3p	CLIP-seq
MIRT2150049	hsa-miR-302f	CLIP-seq
MIRT2150050	hsa-miR-3128	CLIP-seq
MIRT2150051	hsa-miR-3135b	CLIP-seq
MIRT2150052	hsa-miR-3192	CLIP-seq
MIRT2150053	hsa-miR-3650	CLIP-seq
MIRT2150054	hsa-miR-3652	CLIP-seq
MIRT2150055	hsa-miR-3672	CLIP-seq
MIRT1555652	hsa-miR-3689a-3p	CLIP-seq
MIRT1555653	hsa-miR-3689c	CLIP-seq
MIRT2150056	hsa-miR-3689d	CLIP-seq
MIRT2150057	hsa-miR-4423-5p	CLIP-seq
MIRT2150058	hsa-miR-4426	CLIP-seq
MIRT2150059	hsa-miR-4430	CLIP-seq
MIRT2150060	hsa-miR-4433	CLIP-seq
MIRT2150061	hsa-miR-4459	CLIP-seq
MIRT2150062	hsa-miR-4465	CLIP-seq
MIRT2150063	hsa-miR-4537	CLIP-seq
MIRT2150064	hsa-miR-4647	CLIP-seq
MIRT2150065	hsa-miR-4662b	CLIP-seq
MIRT2150066	hsa-miR-4668-3p	CLIP-seq
MIRT2150067	hsa-miR-4684-5p	CLIP-seq
MIRT2150068	hsa-miR-4728-3p	CLIP-seq
MIRT1555654	hsa-miR-4728-5p	CLIP-seq
MIRT2150069	hsa-miR-4768-3p	CLIP-seq
MIRT2150070	hsa-miR-490-3p	CLIP-seq
MIRT2150071	hsa-miR-501-3p	CLIP-seq
MIRT2150072	hsa-miR-502-3p	CLIP-seq
MIRT2150073	hsa-miR-544b	CLIP-seq
MIRT2150074	hsa-miR-548c-3p	CLIP-seq
MIRT2150075	hsa-miR-580	CLIP-seq
MIRT2150076	hsa-miR-628-5p	CLIP-seq
MIRT2150077	hsa-miR-938	CLIP-seq
MIRT2150078	hsa-miR-942	CLIP-seq
MIRT2370128	hsa-miR-494	CLIP-seq
MIRT2150056	hsa-miR-3689d	CLIP-seq
MIRT1498011	hsa-miR-4277	CLIP-seq
MIRT2397114	hsa-miR-129-5p	CLIP-seq
MIRT2397115	hsa-miR-4753-3p	CLIP-seq
MIRT2397116	hsa-miR-4768-5p	CLIP-seq
MIRT2397117	hsa-miR-4776-3p	CLIP-seq
MIRT2441712	hsa-miR-103a	CLIP-seq
MIRT2441713	hsa-miR-3647-3p	CLIP-seq
MIRT2441714	hsa-miR-3944-5p	CLIP-seq
MIRT2441715	hsa-miR-4635	CLIP-seq
MIRT2463671	hsa-miR-1267	CLIP-seq
MIRT2150043	hsa-miR-1273e	CLIP-seq
MIRT1497995	hsa-miR-1827	CLIP-seq
MIRT2463672	hsa-miR-1908	CLIP-seq
MIRT2150048	hsa-miR-2964a-3p	CLIP-seq
MIRT2150049	hsa-miR-302f	CLIP-seq
MIRT2150051	hsa-miR-3135b	CLIP-seq
MIRT2150053	hsa-miR-3650	CLIP-seq
MIRT2150054	hsa-miR-3652	CLIP-seq
MIRT2463673	hsa-miR-3664-5p	CLIP-seq
MIRT2463674	hsa-miR-3675-3p	CLIP-seq
MIRT2463675	hsa-miR-4293	CLIP-seq
MIRT2150057	hsa-miR-4423-5p	CLIP-seq
MIRT2150059	hsa-miR-4430	CLIP-seq
MIRT2463676	hsa-miR-4639-3p	CLIP-seq
MIRT2150067	hsa-miR-4684-5p	CLIP-seq
MIRT2150070	hsa-miR-490-3p	CLIP-seq
MIRT2150074	hsa-miR-548c-3p	CLIP-seq
MIRT2150075	hsa-miR-580	CLIP-seq
MIRT2463677	hsa-miR-596	CLIP-seq
MIRT2463678	hsa-miR-624	CLIP-seq
MIRT2463679	hsa-miR-663	CLIP-seq
MIRT2663908	hsa-miR-142-5p	CLIP-seq
MIRT2663909	hsa-miR-2052	CLIP-seq
MIRT2663910	hsa-miR-30a	CLIP-seq
MIRT2663911	hsa-miR-30b	CLIP-seq
MIRT2663912	hsa-miR-30c	CLIP-seq
MIRT2663913	hsa-miR-30d	CLIP-seq
MIRT2663914	hsa-miR-30e	CLIP-seq
MIRT2663915	hsa-miR-3140-5p	CLIP-seq
MIRT2663916	hsa-miR-320a	CLIP-seq
MIRT2663917	hsa-miR-320b	CLIP-seq
MIRT2663918	hsa-miR-320c	CLIP-seq
MIRT2663919	hsa-miR-320d	CLIP-seq
MIRT2663920	hsa-miR-323-3p	CLIP-seq
MIRT2663921	hsa-miR-338-5p	CLIP-seq
MIRT1498004	hsa-miR-340	CLIP-seq
MIRT2663922	hsa-miR-3613-3p	CLIP-seq
MIRT2663923	hsa-miR-3646	CLIP-seq
MIRT2663924	hsa-miR-3923	CLIP-seq
MIRT2663925	hsa-miR-4307	CLIP-seq
MIRT2663926	hsa-miR-4429	CLIP-seq
MIRT2663927	hsa-miR-4680-3p	CLIP-seq
MIRT2663928	hsa-miR-554	CLIP-seq
MIRT2663929	hsa-miR-628-3p	CLIP-seq
MIRT2663925	hsa-miR-4307	CLIP-seq
MIRT2663925	hsa-miR-4307	CLIP-seq
MIRT2663925	hsa-miR-4307	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IBA
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	11593398
GO:0003714	Function	Transcription corepressor activity	IDA	12706874
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0005515	Function	Protein binding	IPI	9016636, 11593398, 12706874, 21516116, 24981860, 25416956, 27705803, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11593398
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12706874
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	11593398
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607534
• HGNC: 17363
• e!Ensembl: ENSG00000015153

Protein

• UniProt ID: Q8IY57
• Protein name: YY1-associated factor 2
• Protein function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive comple
• PDB: 2D9G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00641	zf-RanBP	20 → 46	Zn-finger in Ran binding protein and others	Domain
  PF17219	YAF2_RYBP	102 → 134	Yaf2/RYBP C-terminal binding motif	Motif

• Sequence:

  MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLV
  AQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTV
  GDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH
  

• Sequence length: 180

Pathways

KEGG:

Polycomb repressive complex

Reactome:

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	32950105	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30915747		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	37382256	Associate	★☆☆☆☆ Found in Text Mining only