Gene Gene information from NCBI Gene database.
Entrez ID 10124
Gene name ARF like GTPase 4A
Gene symbol ARL4A
Synonyms (NCBI Gene)
ARL4
Chromosome 7
Chromosome location 7p21.3
Summary ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is lo
miRNA miRNA information provided by mirtarbase database.
368
miRTarBase ID miRNA Experiments Reference
MIRT030339 hsa-miR-26b-5p Microarray 19088304
MIRT244332 hsa-miR-382-5p HITS-CLIP 24374217
MIRT244332 hsa-miR-382-5p HITS-CLIP 24374217
MIRT797866 hsa-miR-1260 CLIP-seq
MIRT797867 hsa-miR-1260b CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 10980193, 17398095, 25416956, 32296183
GO:0005525 Function GTP binding IBA
GO:0005525 Function GTP binding IDA 10980193
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604786 695 ENSG00000122644
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P40617
Protein name ADP-ribosylation factor-like protein 4A
Protein function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that d
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00025 Arf 8 186 ADP-ribosylation factor family Domain
Sequence
Sequence length 200
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Carcinoma BEFREE 25575132
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy Pubtator 25137373 Associate
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Dilated cardiomyopathy Pubtator 25137373 Associate
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn disease Pubtator 21257989 Associate
★☆☆☆☆
Found in Text Mining only
Glioma Glioma LHGDN 18240926
★☆☆☆☆
Found in Text Mining only
Thrombosis Thrombosis Pubtator 40380263 Associate
★☆☆☆☆
Found in Text Mining only
Venous Thrombosis Venous thrombosis Pubtator 40380263 Associate
★☆☆☆☆
Found in Text Mining only