IFNL4 (interferon lambda 4 (gene/pseudogene))

Gene Gene information from NCBI Gene database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Entrez ID 101180976
Gene name Interferon lambda 4 (gene/pseudogene)
Gene symbol IFNL4
Synonyms (NCBI Gene)
IFNAN
Chromosome 19
Chromosome location 19q13.2
Summary This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frame
SNPs SNP information provided by dbSNP.
2
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all (2)
SNP ID Visualize variation Clinical significance Consequence
rs11322783 TT>G,T Drug-response Non coding transcript variant
rs12979860 C>T Drug-response, benign Intron variant
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Show/Hide all (18)
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IBA
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity IMP 23291588
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
615090 44480 ENSG00000272395
Protein Protein information from UniProt database.
Gene SNPs Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
K9M1U5
Protein name Interferon lambda-4 (IFN-lambda-4)
Protein function Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.
PDB 9BPU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15177 IL28A 24 → 175 Interleukin-28A Domain
Sequence
Sequence length 179
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Gene SNPs Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (10)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CIRRHOSIS OF LIVER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CRYOGLOBULINEMIA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FACTOR VIII DEFICIENCY — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEPATITIS C — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (59)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anemia Anemia Pubtator 26933517 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 31359493
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Hemolytic Hemolytic anemia Pubtator 27833958 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Anorexia Anorexia Pubtator 25449243 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 28874741
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 28874741 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
beta Thalassemia Beta thalassemia Pubtator 25864220 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Blood Coagulation Disorders Blood Coagulation Disorders BEFREE 27735085
★★★★★
★☆☆☆☆
Found in Text Mining only
Bronchiolitis Bronchiolitis Pubtator 22374338, 31645053 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 22310928, 22666430, 23227209, 25227816, 25332265, 25504078, 25837166, 26602024, 26854475, 27035616, 28704535, 29254684, 30344298, 31826071, 32937024
View all (3 more)		 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only