Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10114
Gene name	Homeodomain interacting protein kinase 3
Gene symbol	HIPK3
Synonyms (NCBI Gene)	DYRK6FIST3PKYYAK1
Chromosome	11
Chromosome location	11p13

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001837	hsa-miR-106a-5p	Luciferase reporter assay	17575136
MIRT004064	hsa-miR-19b-3p	Luciferase reporter assay	17575136
MIRT001782	hsa-miR-20b-5p	Luciferase reporter assay	17575136
MIRT004090	hsa-miR-92a-3p	Luciferase reporter assay	17575136
MIRT018461	hsa-miR-335-5p	Microarray	18185580
MIRT022918	hsa-miR-124-3p	Microarray	18668037
MIRT023984	hsa-miR-1-3p	Microarray	18668037
MIRT001837	hsa-miR-106a-5p	Microarray	23807165
MIRT002419	hsa-miR-21-5p	MicroarrayqRT-PCR	22815788
MIRT438276	hsa-miR-187-3p	Luciferase reporter assay	24149837
MIRT438276	hsa-miR-187-3p	Luciferase reporter assay	24149837
MIRT725457	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT725456	hsa-miR-3654	HITS-CLIP	19536157
MIRT725454	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT725455	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT725453	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT725452	hsa-miR-378b	HITS-CLIP	19536157
MIRT725450	hsa-miR-378c	HITS-CLIP	19536157
MIRT725451	hsa-miR-378d	HITS-CLIP	19536157
MIRT725449	hsa-miR-378e	HITS-CLIP	19536157
MIRT725448	hsa-miR-378f	HITS-CLIP	19536157
MIRT725446	hsa-miR-378h	HITS-CLIP	19536157
MIRT725447	hsa-miR-378i	HITS-CLIP	19536157
MIRT725445	hsa-miR-422a	HITS-CLIP	19536157
MIRT725443	hsa-miR-6505-3p	HITS-CLIP	19536157
MIRT725444	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT725442	hsa-miR-6828-3p	HITS-CLIP	19536157
MIRT725441	hsa-miR-6071	HITS-CLIP	19536157
MIRT725439	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT725440	hsa-miR-8058	HITS-CLIP	19536157
MIRT702951	hsa-miR-374c-5p	HITS-CLIP	23313552
MIRT702950	hsa-miR-655-3p	HITS-CLIP	23313552
MIRT702949	hsa-miR-3609	HITS-CLIP	23313552
MIRT702948	hsa-miR-548ah-5p	HITS-CLIP	23313552
MIRT702947	hsa-miR-4760-3p	HITS-CLIP	23313552
MIRT702946	hsa-miR-3973	HITS-CLIP	23313552
MIRT702945	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT702944	hsa-miR-520h	HITS-CLIP	23313552
MIRT702943	hsa-miR-196b-3p	HITS-CLIP	23313552
MIRT702942	hsa-miR-4645-3p	HITS-CLIP	23313552
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT569907	hsa-miR-6776-3p	PAR-CLIP	20371350
MIRT569906	hsa-miR-181c-3p	PAR-CLIP	20371350
MIRT569905	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT569903	hsa-miR-4999-3p	PAR-CLIP	20371350
MIRT569904	hsa-miR-6884-3p	PAR-CLIP	20371350
MIRT569902	hsa-miR-197-3p	PAR-CLIP	20371350
MIRT727495	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT004064	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT732709	hsa-miR-599	Immunoprecipitaion (IP)Luciferase reporter assayqRT-PCRWestern blotting	32189968
MIRT737148	hsa-miR-326	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)Immunohistochemistry (IHC)qRT-PCRFlow cytometry	34135597
MIRT737227	hsa-miR-338-3p	Luciferase reporter assayqRT-PCR	33105143
MIRT725457	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT725456	hsa-miR-3654	HITS-CLIP	19536157
MIRT725454	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT725455	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT725453	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT725452	hsa-miR-378b	HITS-CLIP	19536157
MIRT725450	hsa-miR-378c	HITS-CLIP	19536157
MIRT725451	hsa-miR-378d	HITS-CLIP	19536157
MIRT725449	hsa-miR-378e	HITS-CLIP	19536157
MIRT725448	hsa-miR-378f	HITS-CLIP	19536157
MIRT725446	hsa-miR-378h	HITS-CLIP	19536157
MIRT725447	hsa-miR-378i	HITS-CLIP	19536157
MIRT725445	hsa-miR-422a	HITS-CLIP	19536157
MIRT725443	hsa-miR-6505-3p	HITS-CLIP	19536157
MIRT725444	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT725442	hsa-miR-6828-3p	HITS-CLIP	19536157
MIRT725441	hsa-miR-6071	HITS-CLIP	19536157
MIRT725439	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT725440	hsa-miR-8058	HITS-CLIP	19536157
MIRT702951	hsa-miR-374c-5p	HITS-CLIP	23313552
MIRT702950	hsa-miR-655-3p	HITS-CLIP	23313552
MIRT702949	hsa-miR-3609	HITS-CLIP	23313552
MIRT702948	hsa-miR-548ah-5p	HITS-CLIP	23313552
MIRT702947	hsa-miR-4760-3p	HITS-CLIP	23313552
MIRT702946	hsa-miR-3973	HITS-CLIP	23313552
MIRT702945	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT702944	hsa-miR-520h	HITS-CLIP	23313552
MIRT702943	hsa-miR-196b-3p	HITS-CLIP	23313552
MIRT702942	hsa-miR-4645-3p	HITS-CLIP	23313552
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT611511	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611510	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611509	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611508	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611507	hsa-miR-548z	HITS-CLIP	23824327
MIRT611506	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT611505	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611504	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT569907	hsa-miR-6776-3p	PAR-CLIP	20371350
MIRT569906	hsa-miR-181c-3p	PAR-CLIP	20371350
MIRT569905	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT569903	hsa-miR-4999-3p	PAR-CLIP	20371350
MIRT569904	hsa-miR-6884-3p	PAR-CLIP	20371350
MIRT569902	hsa-miR-197-3p	PAR-CLIP	20371350
MIRT1047354	hsa-miR-1324	CLIP-seq
MIRT1047355	hsa-miR-4766-5p	CLIP-seq
MIRT1047356	hsa-miR-548c-3p	CLIP-seq
MIRT1047357	hsa-miR-548p	CLIP-seq
MIRT1047358	hsa-miR-922	CLIP-seq
MIRT1047359	hsa-miR-1323	CLIP-seq
MIRT1047354	hsa-miR-1324	CLIP-seq
MIRT1047360	hsa-miR-140-3p	CLIP-seq
MIRT1047361	hsa-miR-224	CLIP-seq
MIRT1047362	hsa-miR-297	CLIP-seq
MIRT1047363	hsa-miR-3121-3p	CLIP-seq
MIRT1047364	hsa-miR-3143	CLIP-seq
MIRT1047365	hsa-miR-3148	CLIP-seq
MIRT1047366	hsa-miR-3149	CLIP-seq
MIRT1047367	hsa-miR-323-3p	CLIP-seq
MIRT1047368	hsa-miR-3614-5p	CLIP-seq
MIRT1047369	hsa-miR-3617	CLIP-seq
MIRT1047370	hsa-miR-3622a-3p	CLIP-seq
MIRT1047371	hsa-miR-3622b-3p	CLIP-seq
MIRT1047372	hsa-miR-3646	CLIP-seq
MIRT1047373	hsa-miR-3660	CLIP-seq
MIRT1047374	hsa-miR-3662	CLIP-seq
MIRT1047375	hsa-miR-369-3p	CLIP-seq
MIRT1047376	hsa-miR-374c	CLIP-seq
MIRT1047377	hsa-miR-378	CLIP-seq
MIRT1047378	hsa-miR-4256	CLIP-seq
MIRT1047379	hsa-miR-4290	CLIP-seq
MIRT1047380	hsa-miR-4421	CLIP-seq
MIRT1047381	hsa-miR-4427	CLIP-seq
MIRT1047382	hsa-miR-4462	CLIP-seq
MIRT1047383	hsa-miR-4496	CLIP-seq
MIRT1047384	hsa-miR-4526	CLIP-seq
MIRT1047385	hsa-miR-4666-3p	CLIP-seq
MIRT1047386	hsa-miR-4680-3p	CLIP-seq
MIRT1047387	hsa-miR-4690-5p	CLIP-seq
MIRT1047388	hsa-miR-4704-5p	CLIP-seq
MIRT1047389	hsa-miR-4718	CLIP-seq
MIRT1047390	hsa-miR-4722-5p	CLIP-seq
MIRT1047391	hsa-miR-4728-3p	CLIP-seq
MIRT1047392	hsa-miR-4729	CLIP-seq
MIRT1047393	hsa-miR-4789-5p	CLIP-seq
MIRT1047394	hsa-miR-487a	CLIP-seq
MIRT1047395	hsa-miR-518d-5p	CLIP-seq
MIRT1047396	hsa-miR-519b-5p	CLIP-seq
MIRT1047397	hsa-miR-519c-5p	CLIP-seq
MIRT1047398	hsa-miR-520c-5p	CLIP-seq
MIRT1047399	hsa-miR-526a	CLIP-seq
MIRT1047400	hsa-miR-543	CLIP-seq
MIRT1047401	hsa-miR-548a-3p	CLIP-seq
MIRT1047356	hsa-miR-548c-3p	CLIP-seq
MIRT1047402	hsa-miR-548e	CLIP-seq
MIRT1047403	hsa-miR-548f	CLIP-seq
MIRT1047404	hsa-miR-548o	CLIP-seq
MIRT1047357	hsa-miR-548p	CLIP-seq
MIRT1047405	hsa-miR-590-3p	CLIP-seq
MIRT1047406	hsa-miR-641	CLIP-seq
MIRT1047407	hsa-miR-643	CLIP-seq
MIRT1047408	hsa-miR-655	CLIP-seq
MIRT1047358	hsa-miR-922	CLIP-seq
MIRT1549500	hsa-miR-1227	CLIP-seq
MIRT1549501	hsa-miR-4659a-5p	CLIP-seq
MIRT1549502	hsa-miR-4659b-5p	CLIP-seq
MIRT1549503	hsa-miR-4775	CLIP-seq
MIRT1549504	hsa-miR-578	CLIP-seq
MIRT1549505	hsa-miR-581	CLIP-seq
MIRT1047405	hsa-miR-590-3p	CLIP-seq
MIRT2010732	hsa-miR-124	CLIP-seq
MIRT1047361	hsa-miR-224	CLIP-seq
MIRT1047362	hsa-miR-297	CLIP-seq
MIRT2010733	hsa-miR-299-5p	CLIP-seq
MIRT1047364	hsa-miR-3143	CLIP-seq
MIRT1047366	hsa-miR-3149	CLIP-seq
MIRT1047368	hsa-miR-3614-5p	CLIP-seq
MIRT1047370	hsa-miR-3622a-3p	CLIP-seq
MIRT1047371	hsa-miR-3622b-3p	CLIP-seq
MIRT2010734	hsa-miR-3671	CLIP-seq
MIRT1047375	hsa-miR-369-3p	CLIP-seq
MIRT2010735	hsa-miR-3714	CLIP-seq
MIRT1047376	hsa-miR-374c	CLIP-seq
MIRT1047377	hsa-miR-378	CLIP-seq
MIRT2010736	hsa-miR-3910	CLIP-seq
MIRT2010737	hsa-miR-3914	CLIP-seq
MIRT1047380	hsa-miR-4421	CLIP-seq
MIRT2010738	hsa-miR-4477b	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT1047385	hsa-miR-4666-3p	CLIP-seq
MIRT1047389	hsa-miR-4718	CLIP-seq
MIRT1047391	hsa-miR-4728-3p	CLIP-seq
MIRT1047392	hsa-miR-4729	CLIP-seq
MIRT2010740	hsa-miR-506	CLIP-seq
MIRT1047395	hsa-miR-518d-5p	CLIP-seq
MIRT1047396	hsa-miR-519b-5p	CLIP-seq
MIRT1047397	hsa-miR-519c-5p	CLIP-seq
MIRT1047398	hsa-miR-520c-5p	CLIP-seq
MIRT1047399	hsa-miR-526a	CLIP-seq
MIRT1047400	hsa-miR-543	CLIP-seq
MIRT1047357	hsa-miR-548p	CLIP-seq
MIRT1047407	hsa-miR-643	CLIP-seq
MIRT1047408	hsa-miR-655	CLIP-seq
MIRT2010732	hsa-miR-124	CLIP-seq
MIRT2243016	hsa-miR-1264	CLIP-seq
MIRT2243017	hsa-miR-1267	CLIP-seq
MIRT1047354	hsa-miR-1324	CLIP-seq
MIRT2243018	hsa-miR-135a	CLIP-seq
MIRT2243019	hsa-miR-135b	CLIP-seq
MIRT2243020	hsa-miR-1910	CLIP-seq
MIRT1047361	hsa-miR-224	CLIP-seq
MIRT1047362	hsa-miR-297	CLIP-seq
MIRT2010733	hsa-miR-299-5p	CLIP-seq
MIRT2243021	hsa-miR-3144-3p	CLIP-seq
MIRT1047366	hsa-miR-3149	CLIP-seq
MIRT2243022	hsa-miR-331-5p	CLIP-seq
MIRT1047368	hsa-miR-3614-5p	CLIP-seq
MIRT1047369	hsa-miR-3617	CLIP-seq
MIRT1047370	hsa-miR-3622a-3p	CLIP-seq
MIRT1047371	hsa-miR-3622b-3p	CLIP-seq
MIRT2243023	hsa-miR-3653	CLIP-seq
MIRT1047373	hsa-miR-3660	CLIP-seq
MIRT2243024	hsa-miR-3668	CLIP-seq
MIRT1047375	hsa-miR-369-3p	CLIP-seq
MIRT2010735	hsa-miR-3714	CLIP-seq
MIRT1047376	hsa-miR-374c	CLIP-seq
MIRT1047377	hsa-miR-378	CLIP-seq
MIRT2010736	hsa-miR-3910	CLIP-seq
MIRT2010737	hsa-miR-3914	CLIP-seq
MIRT1047378	hsa-miR-4256	CLIP-seq
MIRT1047380	hsa-miR-4421	CLIP-seq
MIRT1047382	hsa-miR-4462	CLIP-seq
MIRT2010738	hsa-miR-4477b	CLIP-seq
MIRT2243025	hsa-miR-4503	CLIP-seq
MIRT1047384	hsa-miR-4526	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT2243026	hsa-miR-4637	CLIP-seq
MIRT1047385	hsa-miR-4666-3p	CLIP-seq
MIRT2243027	hsa-miR-4672	CLIP-seq
MIRT1047388	hsa-miR-4704-5p	CLIP-seq
MIRT1047389	hsa-miR-4718	CLIP-seq
MIRT1047391	hsa-miR-4728-3p	CLIP-seq
MIRT1047392	hsa-miR-4729	CLIP-seq
MIRT1047393	hsa-miR-4789-5p	CLIP-seq
MIRT2010740	hsa-miR-506	CLIP-seq
MIRT1047395	hsa-miR-518d-5p	CLIP-seq
MIRT1047396	hsa-miR-519b-5p	CLIP-seq
MIRT1047397	hsa-miR-519c-5p	CLIP-seq
MIRT1047398	hsa-miR-520c-5p	CLIP-seq
MIRT1047399	hsa-miR-526a	CLIP-seq
MIRT1047356	hsa-miR-548c-3p	CLIP-seq
MIRT1047357	hsa-miR-548p	CLIP-seq
MIRT1047406	hsa-miR-641	CLIP-seq
MIRT1047407	hsa-miR-643	CLIP-seq
MIRT2243028	hsa-miR-645	CLIP-seq
MIRT1047408	hsa-miR-655	CLIP-seq
MIRT1047358	hsa-miR-922	CLIP-seq
MIRT2010733	hsa-miR-299-5p	CLIP-seq
MIRT2010737	hsa-miR-3914	CLIP-seq
MIRT2243016	hsa-miR-1264	CLIP-seq
MIRT2243017	hsa-miR-1267	CLIP-seq
MIRT2243018	hsa-miR-135a	CLIP-seq
MIRT2243019	hsa-miR-135b	CLIP-seq
MIRT2243020	hsa-miR-1910	CLIP-seq
MIRT2429577	hsa-miR-302a	CLIP-seq
MIRT2429578	hsa-miR-302b	CLIP-seq
MIRT2429579	hsa-miR-302c	CLIP-seq
MIRT2429580	hsa-miR-302d	CLIP-seq
MIRT2429581	hsa-miR-302e	CLIP-seq
MIRT1047364	hsa-miR-3143	CLIP-seq
MIRT1047369	hsa-miR-3617	CLIP-seq
MIRT2010734	hsa-miR-3671	CLIP-seq
MIRT2429582	hsa-miR-372	CLIP-seq
MIRT2429583	hsa-miR-373	CLIP-seq
MIRT1047381	hsa-miR-4427	CLIP-seq
MIRT1047382	hsa-miR-4462	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT2243027	hsa-miR-4672	CLIP-seq
MIRT1047386	hsa-miR-4680-3p	CLIP-seq
MIRT1047388	hsa-miR-4704-5p	CLIP-seq
MIRT1047392	hsa-miR-4729	CLIP-seq
MIRT1047393	hsa-miR-4789-5p	CLIP-seq
MIRT2429584	hsa-miR-512-3p	CLIP-seq
MIRT2429585	hsa-miR-519a	CLIP-seq
MIRT2429586	hsa-miR-519b-3p	CLIP-seq
MIRT2429587	hsa-miR-519c-3p	CLIP-seq
MIRT2429588	hsa-miR-520a-3p	CLIP-seq
MIRT2429589	hsa-miR-520b	CLIP-seq
MIRT2429590	hsa-miR-520c-3p	CLIP-seq
MIRT2429591	hsa-miR-520d-3p	CLIP-seq
MIRT2429592	hsa-miR-520e	CLIP-seq
MIRT1047400	hsa-miR-543	CLIP-seq
MIRT1047405	hsa-miR-590-3p	CLIP-seq
MIRT1047406	hsa-miR-641	CLIP-seq
MIRT1047392	hsa-miR-4729	CLIP-seq
MIRT2243016	hsa-miR-1264	CLIP-seq
MIRT2243017	hsa-miR-1267	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT2243016	hsa-miR-1264	CLIP-seq
MIRT2243017	hsa-miR-1267	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT2243016	hsa-miR-1264	CLIP-seq
MIRT2243017	hsa-miR-1267	CLIP-seq
MIRT2682318	hsa-miR-4495	CLIP-seq
MIRT2010739	hsa-miR-455-5p	CLIP-seq
MIRT2682319	hsa-miR-4643	CLIP-seq
MIRT2682320	hsa-miR-642b	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	14766760
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9748262
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10919273
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS	11034606
GO:0004713	Function	Protein tyrosine kinase activity	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006468	Process	Protein phosphorylation	IDA	14766760
GO:0006915	Process	Apoptotic process	IEA
GO:0009299	Process	MRNA transcription	IDA	17210646
GO:0016301	Function	Kinase activity	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016605	Component	PML body	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	ISS	11034606
GO:0018107	Process	Peptidyl-threonine phosphorylation	ISS	11034606
GO:0043066	Process	Negative regulation of apoptotic process	IMP	14766760
GO:0043508	Process	Negative regulation of JUN kinase activity	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
604424	4915	ENSG00000110422

Q9H422

Protein name

Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)

Protein function

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor

PDB

7O7I , 7O7J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	197 → 525	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver an

Sequence

MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP
GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
GFPLSPTKLSQYPYM

Sequence length

1215

Interactions

View interactions

	KEGG
	Cellular senescence

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PERIPHERAL VASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	36703984	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	37681455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32066649, 34785661, 37536436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35212603	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30352682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	29949144	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33495417	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	31799682	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	38105269	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29700213		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29700213	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	31595165		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Complications	Diabetes complications	Pubtator	35200097, 37681455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28860123		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	35200097	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	24149837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Cardiomyopathies	Diabetic cardiomyopathy	Pubtator	35200097	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Cardiomyopathies	Diabetic cardiomyopathy	Pubtator	37681455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	37681455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	29928876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29805677, 30576808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	31595165		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	29130397, 29134957, 29151587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	17575136		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29805677		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37866205	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	28794202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	29949144	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	29928876		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30352682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30405788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	36530027	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30498360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30498360, 31232177, 31597523		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	32767319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29805712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34268922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	30068360, 36306116	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	14766760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	14766760	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	35148669	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30068360, 31599413	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	28794202	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	40280416	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Calcification	Vascular calcification	Pubtator	38012555	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	37681455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HIPK3 (homeodomain interacting protein kinase 3)