Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10107
Gene name	Tripartite motif containing 10
Gene symbol	TRIM10
Synonyms (NCBI Gene)	HERF1RFB30RNF9
Chromosome	6
Chromosome location	6p22.1
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Stud

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miRTarBase ID	miRNA	Experiments	Reference
MIRT643366	hsa-miR-4426	HITS-CLIP	23824327
MIRT643365	hsa-miR-4647	HITS-CLIP	23824327
MIRT643364	hsa-miR-4662b	HITS-CLIP	23824327
MIRT643363	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT643362	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643361	hsa-miR-591	HITS-CLIP	23824327
MIRT643360	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT643359	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT643358	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643357	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643356	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT643355	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT643353	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643352	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT643351	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT643350	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643349	hsa-miR-7641	HITS-CLIP	23824327
MIRT643348	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT616398	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT616397	hsa-miR-657	HITS-CLIP	23824327
MIRT616396	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT616395	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT616394	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT616393	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT572453	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT572452	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT572451	hsa-miR-1825	PAR-CLIP	20371350
MIRT572450	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT572449	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT572448	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT572447	hsa-miR-345-5p	PAR-CLIP	20371350
MIRT572446	hsa-miR-3182	PAR-CLIP	20371350
MIRT572445	hsa-miR-617	PAR-CLIP	20371350
MIRT572444	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT572443	hsa-miR-938	PAR-CLIP	20371350
MIRT572442	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT572441	hsa-miR-6740-3p	PAR-CLIP	20371350
MIRT572440	hsa-miR-3671	PAR-CLIP	20371350
MIRT572438	hsa-miR-4256	PAR-CLIP	20371350
MIRT572439	hsa-miR-607	PAR-CLIP	20371350
MIRT643366	hsa-miR-4426	HITS-CLIP	23824327
MIRT643365	hsa-miR-4647	HITS-CLIP	23824327
MIRT643364	hsa-miR-4662b	HITS-CLIP	23824327
MIRT643363	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT643362	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643361	hsa-miR-591	HITS-CLIP	23824327
MIRT643360	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT643359	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT643358	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643357	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643356	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT643355	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT643353	hsa-miR-3151-3p	HITS-CLIP	23824327
MIRT643354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT643352	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT643351	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT643350	hsa-miR-3192-3p	HITS-CLIP	23824327
MIRT643349	hsa-miR-7641	HITS-CLIP	23824327
MIRT643348	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT616398	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT616397	hsa-miR-657	HITS-CLIP	23824327
MIRT616396	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT616395	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT616394	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT616393	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT572453	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT572452	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT572451	hsa-miR-1825	PAR-CLIP	20371350
MIRT572450	hsa-miR-199a-5p	PAR-CLIP	20371350
MIRT572449	hsa-miR-199b-5p	PAR-CLIP	20371350
MIRT572448	hsa-miR-4726-3p	PAR-CLIP	20371350
MIRT572447	hsa-miR-345-5p	PAR-CLIP	20371350
MIRT572446	hsa-miR-3182	PAR-CLIP	20371350
MIRT572445	hsa-miR-617	PAR-CLIP	20371350
MIRT572444	hsa-miR-6505-3p	PAR-CLIP	20371350
MIRT572443	hsa-miR-938	PAR-CLIP	20371350
MIRT572442	hsa-miR-6886-3p	PAR-CLIP	20371350
MIRT572441	hsa-miR-6740-3p	PAR-CLIP	20371350
MIRT572440	hsa-miR-3671	PAR-CLIP	20371350
MIRT572438	hsa-miR-4256	PAR-CLIP	20371350
MIRT572439	hsa-miR-607	PAR-CLIP	20371350
MIRT1452889	hsa-miR-3163	CLIP-seq
MIRT1452890	hsa-miR-345	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452892	hsa-miR-4290	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq
MIRT2135657	hsa-miR-3909	CLIP-seq
MIRT2356866	hsa-miR-1229	CLIP-seq
MIRT1452890	hsa-miR-345	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq
MIRT1452891	hsa-miR-383	CLIP-seq
MIRT1452893	hsa-miR-4772-5p	CLIP-seq
MIRT1452894	hsa-miR-7	CLIP-seq
MIRT1452895	hsa-miR-873	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA

MIM	HGNC	e!Ensembl
605701	10072	ENSG00000204613

Q9UDY6

Protein name

Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)

Protein function

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (

PDB

7QS0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15227	zf-C3HC4_4	16 → 60		Domain
PF00643	zf-B_box	94 → 135	B-box zinc finger	Domain
PF13765	PRY	312 → 360	SPRY-associated domain	Family
PF00622	SPRY	364 → 481	SPRY domain	Family

Sequence

MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC
KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVV
CREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVST
KRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELE
EKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEK
LCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGI
TGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPT
RLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLS
S

Sequence length

481

Interactions

View interactions

	Reactome
			Interferon gamma signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, IRRITANT	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Child Development Disorders, Pervasive	Development Disorder	GWASCAT_DG	28540026		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis, Irritant	Dermatitis	CTD_human_DG	27258892		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	19143812	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	GWASDB_DG	21725308		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	28586827	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31472958		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	17804836, 19503088		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	28540026		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TRIM10 (tripartite motif containing 10)