Gene Gene information from NCBI Gene database.
Entrez ID 10100
Gene name Tetraspanin 2
Gene symbol TSPAN2
Synonyms (NCBI Gene)
NET3TSN2TSPAN-2
Chromosome 1
Chromosome location 1p13.2
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
miRNA miRNA information provided by mirtarbase database.
231
miRTarBase ID miRNA Experiments Reference
MIRT520451 hsa-miR-6074 HITS-CLIP 19536157
MIRT520450 hsa-miR-664a-3p HITS-CLIP 19536157
MIRT520445 hsa-miR-452-3p HITS-CLIP 19536157
MIRT509193 hsa-miR-8485 HITS-CLIP 19536157
MIRT509192 hsa-miR-329-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25814554, 32296183, 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0006954 Process Inflammatory response IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613133 20659 ENSG00000134198
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60636
Protein name Tetraspanin-2 (Tspan-2) (Tetraspan NET-3)
Protein function May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 11 213 Tetraspanin family Family
Sequence
Sequence length 221
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CEREBROVASCULAR ACCIDENT Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Cerebrovascular Accidents Stroke CTD_human_DG 29531354
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 26708676 Associate
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar disorder Pubtator 36624117 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 24726368
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Ischemic stroke Pubtator 26708676 Associate
★☆☆☆☆
Found in Text Mining only
Cerebrovascular accident Stroke BEFREE 26708676
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cerebrovascular accident Stroke CTD_human_DG 29531354
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cognition Disorders Cognition disorder Pubtator 36624117 Associate
★☆☆☆☆
Found in Text Mining only
Disruptive Impulse Control and Conduct Disorders Disruptive, impulse control, and conduct disorders Pubtator 36624117 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 24726368
★☆☆☆☆
Found in Text Mining only