TSPAN5 (tetraspanin 5)

Gene

• Entrez ID: 10098
• Gene name: Tetraspanin 5
• Gene symbol: TSPAN5
• Synonyms (NCBI Gene): NET-4, NET4, TM4SF9, TSPAN-5
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018927	hsa-miR-335-5p	Microarray	18185580
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT1459858	hsa-miR-1226	CLIP-seq
MIRT1459859	hsa-miR-15a	CLIP-seq
MIRT1459860	hsa-miR-15b	CLIP-seq
MIRT1459861	hsa-miR-16	CLIP-seq
MIRT1459862	hsa-miR-195	CLIP-seq
MIRT1459863	hsa-miR-208a	CLIP-seq
MIRT1459864	hsa-miR-208b	CLIP-seq
MIRT1459865	hsa-miR-2355-5p	CLIP-seq
MIRT1459866	hsa-miR-27a	CLIP-seq
MIRT1459867	hsa-miR-27b	CLIP-seq
MIRT1459868	hsa-miR-3138	CLIP-seq
MIRT1459869	hsa-miR-3145-3p	CLIP-seq
MIRT739247	hsa-miR-3179	CLIP-seq
MIRT1459870	hsa-miR-323-3p	CLIP-seq
MIRT1459871	hsa-miR-34b	CLIP-seq
MIRT1459872	hsa-miR-3616-3p	CLIP-seq
MIRT1459873	hsa-miR-424	CLIP-seq
MIRT1459874	hsa-miR-4310	CLIP-seq
MIRT1459875	hsa-miR-4311	CLIP-seq
MIRT1459876	hsa-miR-4318	CLIP-seq
MIRT1459877	hsa-miR-4328	CLIP-seq
MIRT1459878	hsa-miR-4459	CLIP-seq
MIRT1459879	hsa-miR-4468	CLIP-seq
MIRT1459880	hsa-miR-4639-3p	CLIP-seq
MIRT1459881	hsa-miR-4686	CLIP-seq
MIRT1459882	hsa-miR-4698	CLIP-seq
MIRT1459883	hsa-miR-4705	CLIP-seq
MIRT1459884	hsa-miR-4779	CLIP-seq
MIRT1459885	hsa-miR-497	CLIP-seq
MIRT1459886	hsa-miR-499-5p	CLIP-seq
MIRT1459887	hsa-miR-513a-5p	CLIP-seq
MIRT1459888	hsa-miR-513c	CLIP-seq
MIRT1459889	hsa-miR-514b-5p	CLIP-seq
MIRT1459890	hsa-miR-520d-5p	CLIP-seq
MIRT1459891	hsa-miR-524-5p	CLIP-seq
MIRT1459892	hsa-miR-556-3p	CLIP-seq
MIRT1459893	hsa-miR-665	CLIP-seq
MIRT1459894	hsa-miR-767-3p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT1555229	hsa-miR-4778-5p	CLIP-seq
MIRT1555230	hsa-miR-485-3p	CLIP-seq
MIRT2138026	hsa-miR-1207-5p	CLIP-seq
MIRT2138027	hsa-miR-1246	CLIP-seq
MIRT2138028	hsa-miR-1253	CLIP-seq
MIRT2138029	hsa-miR-1297	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2138035	hsa-miR-26a	CLIP-seq
MIRT2138036	hsa-miR-26b	CLIP-seq
MIRT1459866	hsa-miR-27a	CLIP-seq
MIRT1459867	hsa-miR-27b	CLIP-seq
MIRT2138037	hsa-miR-3130-3p	CLIP-seq
MIRT2138038	hsa-miR-3134	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2138042	hsa-miR-3185	CLIP-seq
MIRT2138043	hsa-miR-3192	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138045	hsa-miR-3689a-3p	CLIP-seq
MIRT2138046	hsa-miR-3689c	CLIP-seq
MIRT2138047	hsa-miR-3942-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2138049	hsa-miR-4320	CLIP-seq
MIRT2138050	hsa-miR-4463	CLIP-seq
MIRT2138051	hsa-miR-4465	CLIP-seq
MIRT2138052	hsa-miR-4494	CLIP-seq
MIRT2138053	hsa-miR-455-5p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT739246	hsa-miR-4728-5p	CLIP-seq
MIRT2138056	hsa-miR-4763-3p	CLIP-seq
MIRT2138057	hsa-miR-4793-3p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT1459887	hsa-miR-513a-5p	CLIP-seq
MIRT2138060	hsa-miR-544	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2358928	hsa-miR-101	CLIP-seq
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT2358929	hsa-miR-106a	CLIP-seq
MIRT2358930	hsa-miR-106b	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT2358931	hsa-miR-1207-3p	CLIP-seq
MIRT1459858	hsa-miR-1226	CLIP-seq
MIRT2358932	hsa-miR-1260	CLIP-seq
MIRT2358933	hsa-miR-1260b	CLIP-seq
MIRT2358934	hsa-miR-1287	CLIP-seq
MIRT2358935	hsa-miR-1299	CLIP-seq
MIRT2358936	hsa-miR-1301	CLIP-seq
MIRT2358937	hsa-miR-139-5p	CLIP-seq
MIRT2358938	hsa-miR-140-5p	CLIP-seq
MIRT2358939	hsa-miR-143	CLIP-seq
MIRT2358940	hsa-miR-144	CLIP-seq
MIRT2358941	hsa-miR-17	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2358942	hsa-miR-188-3p	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2358943	hsa-miR-20a	CLIP-seq
MIRT2358944	hsa-miR-20b	CLIP-seq
MIRT2358945	hsa-miR-29a	CLIP-seq
MIRT2358946	hsa-miR-29b	CLIP-seq
MIRT2358947	hsa-miR-29c	CLIP-seq
MIRT2358948	hsa-miR-3065-3p	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT739248	hsa-miR-3154	CLIP-seq
MIRT2358949	hsa-miR-3156-3p	CLIP-seq
MIRT2358950	hsa-miR-3164	CLIP-seq
MIRT739247	hsa-miR-3179	CLIP-seq
MIRT2358951	hsa-miR-3609	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2358954	hsa-miR-4301	CLIP-seq
MIRT1459875	hsa-miR-4311	CLIP-seq
MIRT1459876	hsa-miR-4318	CLIP-seq
MIRT2358955	hsa-miR-4427	CLIP-seq
MIRT2358956	hsa-miR-4431	CLIP-seq
MIRT2358957	hsa-miR-4447	CLIP-seq
MIRT2358958	hsa-miR-4472	CLIP-seq
MIRT2358959	hsa-miR-4488	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2138052	hsa-miR-4494	CLIP-seq
MIRT2358961	hsa-miR-4499	CLIP-seq
MIRT2358962	hsa-miR-4522	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2358963	hsa-miR-4697-5p	CLIP-seq
MIRT739246	hsa-miR-4728-5p	CLIP-seq
MIRT2358964	hsa-miR-4733-3p	CLIP-seq
MIRT2358965	hsa-miR-4756-3p	CLIP-seq
MIRT2358966	hsa-miR-4760-3p	CLIP-seq
MIRT2358967	hsa-miR-4770	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2358969	hsa-miR-4795-5p	CLIP-seq
MIRT2358970	hsa-miR-4796-3p	CLIP-seq
MIRT2358971	hsa-miR-4797-5p	CLIP-seq
MIRT2358972	hsa-miR-486-3p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2358973	hsa-miR-5047	CLIP-seq
MIRT2358974	hsa-miR-519d	CLIP-seq
MIRT2358975	hsa-miR-541	CLIP-seq
MIRT2358976	hsa-miR-548ah	CLIP-seq
MIRT2358977	hsa-miR-548v	CLIP-seq
MIRT2358978	hsa-miR-628-5p	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2358979	hsa-miR-654-5p	CLIP-seq
MIRT2358980	hsa-miR-7	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2358981	hsa-miR-875-3p	CLIP-seq
MIRT2358982	hsa-miR-93	CLIP-seq
MIRT2358983	hsa-miR-936	CLIP-seq
MIRT1459856	hsa-miR-103a	CLIP-seq
MIRT1459857	hsa-miR-107	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2396424	hsa-miR-4513	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652179	hsa-miR-1252	CLIP-seq
MIRT2652180	hsa-miR-146a	CLIP-seq
MIRT2652181	hsa-miR-146b-5p	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2652182	hsa-miR-1912	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652183	hsa-miR-2276	CLIP-seq
MIRT2652184	hsa-miR-28-5p	CLIP-seq
MIRT2652185	hsa-miR-3064-5p	CLIP-seq
MIRT2652186	hsa-miR-3128	CLIP-seq
MIRT2652187	hsa-miR-3139	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2652188	hsa-miR-3180-5p	CLIP-seq
MIRT2652189	hsa-miR-3187-3p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2652190	hsa-miR-3692	CLIP-seq
MIRT2652191	hsa-miR-3925-5p	CLIP-seq
MIRT2652192	hsa-miR-3973	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2652193	hsa-miR-4279	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2652194	hsa-miR-4420	CLIP-seq
MIRT2652195	hsa-miR-4452	CLIP-seq
MIRT2652196	hsa-miR-4470	CLIP-seq
MIRT2652197	hsa-miR-4474-5p	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2652198	hsa-miR-4529-5p	CLIP-seq
MIRT2138053	hsa-miR-455-5p	CLIP-seq
MIRT2652199	hsa-miR-4633-3p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2652200	hsa-miR-4762-5p	CLIP-seq
MIRT2652201	hsa-miR-4772-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2652202	hsa-miR-4793-5p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2652203	hsa-miR-520a-5p	CLIP-seq
MIRT2652204	hsa-miR-525-5p	CLIP-seq
MIRT2652205	hsa-miR-548l	CLIP-seq
MIRT2652206	hsa-miR-604	CLIP-seq
MIRT2652207	hsa-miR-630	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2652208	hsa-miR-647	CLIP-seq
MIRT2652209	hsa-miR-708	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT2652210	hsa-miR-934	CLIP-seq
MIRT2652179	hsa-miR-1252	CLIP-seq
MIRT2652180	hsa-miR-146a	CLIP-seq
MIRT2652181	hsa-miR-146b-5p	CLIP-seq
MIRT2138030	hsa-miR-181a	CLIP-seq
MIRT2138031	hsa-miR-181b	CLIP-seq
MIRT2138032	hsa-miR-181c	CLIP-seq
MIRT2138033	hsa-miR-181d	CLIP-seq
MIRT2138034	hsa-miR-203	CLIP-seq
MIRT2652183	hsa-miR-2276	CLIP-seq
MIRT2652184	hsa-miR-28-5p	CLIP-seq
MIRT2652185	hsa-miR-3064-5p	CLIP-seq
MIRT2652187	hsa-miR-3139	CLIP-seq
MIRT2138039	hsa-miR-3148	CLIP-seq
MIRT2138040	hsa-miR-3150a-5p	CLIP-seq
MIRT2138041	hsa-miR-3150b-5p	CLIP-seq
MIRT2652189	hsa-miR-3187-3p	CLIP-seq
MIRT2358952	hsa-miR-3675-5p	CLIP-seq
MIRT2138044	hsa-miR-3688-3p	CLIP-seq
MIRT2652190	hsa-miR-3692	CLIP-seq
MIRT2652191	hsa-miR-3925-5p	CLIP-seq
MIRT2652192	hsa-miR-3973	CLIP-seq
MIRT2138048	hsa-miR-4262	CLIP-seq
MIRT2358953	hsa-miR-4283	CLIP-seq
MIRT2652197	hsa-miR-4474-5p	CLIP-seq
MIRT2358960	hsa-miR-4489	CLIP-seq
MIRT2652198	hsa-miR-4529-5p	CLIP-seq
MIRT2652199	hsa-miR-4633-3p	CLIP-seq
MIRT2138054	hsa-miR-4656	CLIP-seq
MIRT2138055	hsa-miR-4694-3p	CLIP-seq
MIRT2652201	hsa-miR-4772-3p	CLIP-seq
MIRT2358968	hsa-miR-4775	CLIP-seq
MIRT2652202	hsa-miR-4793-5p	CLIP-seq
MIRT2138058	hsa-miR-501-3p	CLIP-seq
MIRT2138059	hsa-miR-502-3p	CLIP-seq
MIRT2652205	hsa-miR-548l	CLIP-seq
MIRT2652206	hsa-miR-604	CLIP-seq
MIRT2652207	hsa-miR-630	CLIP-seq
MIRT2138061	hsa-miR-642b	CLIP-seq
MIRT2652208	hsa-miR-647	CLIP-seq
MIRT2652209	hsa-miR-708	CLIP-seq
MIRT2138062	hsa-miR-767-5p	CLIP-seq
MIRT1459895	hsa-miR-875-5p	CLIP-seq
MIRT2652210	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23091066, 26686862, 31792032, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23091066, 31792032
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008104	Process	Intracellular protein localization	IEA
GO:0016020	Component	Membrane	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	IPI	23091066
GO:0045747	Process	Positive regulation of Notch signaling pathway	IMP	23091066
GO:0051043	Process	Regulation of membrane protein ectodomain proteolysis	IDA	28600292, 31792032
GO:0051604	Process	Protein maturation	IEA
GO:0051604	Process	Protein maturation	IMP	23091066
GO:0072659	Process	Protein localization to plasma membrane	IMP	23091066

Other IDs

• MIM: 613136
• HGNC: 17753
• e!Ensembl: ENSG00000168785

Protein

• UniProt ID: P62079
• Protein name: Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
• Protein function: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell sur
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	15 → 260	Tetraspanin family	Family

• Sequence:

  MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFD
  PVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIK
  DQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERC
  GVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIF
  IGIALLQIFGICLAQNLVSDIEAVRASW

• Sequence length: 268

Pathways

Reactome:

Amyloid fiber formation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bone Diseases Metabolic	Bone disease	Pubtator	36728938	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33955149	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37047447	Stimulate	★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	26903268, 32753686	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	29750314		★☆☆☆☆ Found in Text Mining only
Familial Primary Pulmonary Hypertension	Pulmonary hypertension	Pubtator	34722766	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	31012492		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	26903268		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	29750314		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	22491018		★☆☆☆☆ Found in Text Mining only