ARPC1B (actin related protein 2/3 complex subunit 1B)

Gene

• Entrez ID: 10095
• Gene name: Actin related protein 2/3 complex subunit 1B
• Gene symbol: ARPC1B
• Synonyms (NCBI Gene): ARC41, IMD71, PLTEID, p40-ARC, p41-ARC
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they bo

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs111297226	G>A,C	Pathogenic	Splice donor variant
rs760191638	CTGCT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1186149065	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs1584409386	->CC	Pathogenic	Coding sequence variant, frameshift variant
rs1584410808	GA>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002566	hsa-miR-124-3p	Microarray	15685193
MIRT002566	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT002566	hsa-miR-124-3p	Microarray	15685193
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23313552
MIRT616873	hsa-miR-3941	HITS-CLIP	23313552
MIRT616872	hsa-miR-4672	HITS-CLIP	23313552
MIRT616871	hsa-miR-466	HITS-CLIP	23313552
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23313552
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT635904	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT635903	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621204	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT621203	hsa-miR-4488	HITS-CLIP	23824327
MIRT621202	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT621201	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT621200	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT621199	hsa-miR-1275	HITS-CLIP	23824327
MIRT621198	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT621197	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT621196	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT621195	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT635907	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT635906	hsa-miR-4260	HITS-CLIP	23824327
MIRT635905	hsa-miR-5572	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT635904	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT635903	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621204	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT621203	hsa-miR-4488	HITS-CLIP	23824327
MIRT621202	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT621201	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT621200	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT621199	hsa-miR-1275	HITS-CLIP	23824327
MIRT621198	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT621197	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT621196	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT621195	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612122	hsa-miR-4422	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612117	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT612116	hsa-miR-3658	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT441178	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441178	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT616870	hsa-miR-2681-5p	PAR-CLIP	26701625
MIRT616870	hsa-miR-2681-5p	PAR-CLIP	26701625
MIRT616870	hsa-miR-2681-5p	PAR-CLIP	26701625
MIRT635904	hsa-miR-33a-5p	PAR-CLIP	26701625
MIRT635904	hsa-miR-33a-5p	PAR-CLIP	26701625
MIRT635904	hsa-miR-33a-5p	PAR-CLIP	26701625
MIRT635903	hsa-miR-33b-5p	PAR-CLIP	26701625
MIRT635903	hsa-miR-33b-5p	PAR-CLIP	26701625
MIRT635903	hsa-miR-33b-5p	PAR-CLIP	26701625
MIRT616873	hsa-miR-3941	PAR-CLIP	26701625
MIRT616873	hsa-miR-3941	PAR-CLIP	26701625
MIRT616873	hsa-miR-3941	PAR-CLIP	26701625
MIRT616871	hsa-miR-466	PAR-CLIP	26701625
MIRT616871	hsa-miR-466	PAR-CLIP	26701625
MIRT616871	hsa-miR-466	PAR-CLIP	26701625
MIRT616872	hsa-miR-4672	PAR-CLIP	26701625
MIRT616872	hsa-miR-4672	PAR-CLIP	26701625
MIRT616872	hsa-miR-4672	PAR-CLIP	26701625
MIRT616875	hsa-miR-6768-5p	PAR-CLIP	26701625
MIRT616875	hsa-miR-6768-5p	PAR-CLIP	26701625
MIRT616875	hsa-miR-6768-5p	PAR-CLIP	26701625
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	27418678
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	27418678
MIRT616873	hsa-miR-3941	HITS-CLIP	27418678
MIRT616873	hsa-miR-3941	HITS-CLIP	27418678
MIRT616871	hsa-miR-466	HITS-CLIP	27418678
MIRT616871	hsa-miR-466	HITS-CLIP	27418678
MIRT616872	hsa-miR-4672	HITS-CLIP	27418678
MIRT616872	hsa-miR-4672	HITS-CLIP	27418678
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	27418678
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	27418678
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23313552
MIRT616873	hsa-miR-3941	HITS-CLIP	23313552
MIRT616872	hsa-miR-4672	HITS-CLIP	23313552
MIRT616871	hsa-miR-466	HITS-CLIP	23313552
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23313552
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT635904	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT635903	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621204	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT621203	hsa-miR-4488	HITS-CLIP	23824327
MIRT621202	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT621201	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT621200	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT621199	hsa-miR-1275	HITS-CLIP	23824327
MIRT621198	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT621197	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT621196	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT621195	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT635907	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT635906	hsa-miR-4260	HITS-CLIP	23824327
MIRT635905	hsa-miR-5572	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT635904	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT635903	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621204	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT621203	hsa-miR-4488	HITS-CLIP	23824327
MIRT621202	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT621201	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT621200	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT621199	hsa-miR-1275	HITS-CLIP	23824327
MIRT621198	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT621197	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT621196	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT621195	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT616875	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT616874	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT616873	hsa-miR-3941	HITS-CLIP	23824327
MIRT616872	hsa-miR-4672	HITS-CLIP	23824327
MIRT616871	hsa-miR-466	HITS-CLIP	23824327
MIRT616870	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612122	hsa-miR-4422	HITS-CLIP	23824327
MIRT612121	hsa-miR-3646	HITS-CLIP	23824327
MIRT612120	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT612119	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT612118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT612117	hsa-miR-3653-3p	HITS-CLIP	23824327
MIRT612116	hsa-miR-3658	HITS-CLIP	23824327
MIRT612115	hsa-miR-1305	HITS-CLIP	23824327
MIRT612114	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT799693	hsa-miR-1206	CLIP-seq
MIRT799694	hsa-miR-124	CLIP-seq
MIRT799695	hsa-miR-1263	CLIP-seq
MIRT799696	hsa-miR-127-5p	CLIP-seq
MIRT799697	hsa-miR-181a	CLIP-seq
MIRT799698	hsa-miR-181b	CLIP-seq
MIRT799699	hsa-miR-181c	CLIP-seq
MIRT799700	hsa-miR-181d	CLIP-seq
MIRT799701	hsa-miR-330-3p	CLIP-seq
MIRT799702	hsa-miR-338-3p	CLIP-seq
MIRT799703	hsa-miR-3622a-5p	CLIP-seq
MIRT799704	hsa-miR-4262	CLIP-seq
MIRT799705	hsa-miR-4291	CLIP-seq
MIRT799706	hsa-miR-433	CLIP-seq
MIRT799707	hsa-miR-4473	CLIP-seq
MIRT799708	hsa-miR-4777-3p	CLIP-seq
MIRT799709	hsa-miR-494	CLIP-seq
MIRT799710	hsa-miR-502-5p	CLIP-seq
MIRT799711	hsa-miR-506	CLIP-seq
MIRT799712	hsa-miR-512-3p	CLIP-seq
MIRT799713	hsa-miR-520f	CLIP-seq
MIRT799714	hsa-miR-543	CLIP-seq
MIRT799715	hsa-miR-545	CLIP-seq
MIRT799716	hsa-miR-634	CLIP-seq
MIRT799693	hsa-miR-1206	CLIP-seq
MIRT1936245	hsa-miR-1265	CLIP-seq
MIRT799696	hsa-miR-127-5p	CLIP-seq
MIRT1936246	hsa-miR-1292	CLIP-seq
MIRT799697	hsa-miR-181a	CLIP-seq
MIRT799698	hsa-miR-181b	CLIP-seq
MIRT799699	hsa-miR-181c	CLIP-seq
MIRT799700	hsa-miR-181d	CLIP-seq
MIRT1936247	hsa-miR-2355-5p	CLIP-seq
MIRT1936248	hsa-miR-2392	CLIP-seq
MIRT799701	hsa-miR-330-3p	CLIP-seq
MIRT799702	hsa-miR-338-3p	CLIP-seq
MIRT1936249	hsa-miR-33a	CLIP-seq
MIRT1936250	hsa-miR-33b	CLIP-seq
MIRT799704	hsa-miR-4262	CLIP-seq
MIRT799705	hsa-miR-4291	CLIP-seq
MIRT799706	hsa-miR-433	CLIP-seq
MIRT1936251	hsa-miR-4471	CLIP-seq
MIRT799707	hsa-miR-4473	CLIP-seq
MIRT1936252	hsa-miR-4493	CLIP-seq
MIRT1936253	hsa-miR-4530	CLIP-seq
MIRT799708	hsa-miR-4777-3p	CLIP-seq
MIRT799710	hsa-miR-502-5p	CLIP-seq
MIRT799712	hsa-miR-512-3p	CLIP-seq
MIRT799713	hsa-miR-520f	CLIP-seq
MIRT799714	hsa-miR-543	CLIP-seq
MIRT799715	hsa-miR-545	CLIP-seq
MIRT799716	hsa-miR-634	CLIP-seq
MIRT1936254	hsa-miR-646	CLIP-seq
MIRT799693	hsa-miR-1206	CLIP-seq
MIRT799696	hsa-miR-127-5p	CLIP-seq
MIRT799702	hsa-miR-338-3p	CLIP-seq
MIRT799706	hsa-miR-433	CLIP-seq
MIRT799707	hsa-miR-4473	CLIP-seq
MIRT799712	hsa-miR-512-3p	CLIP-seq
MIRT799713	hsa-miR-520f	CLIP-seq
MIRT799716	hsa-miR-634	CLIP-seq
MIRT1936245	hsa-miR-1265	CLIP-seq
MIRT1936247	hsa-miR-2355-5p	CLIP-seq
MIRT1936248	hsa-miR-2392	CLIP-seq
MIRT1936252	hsa-miR-4493	CLIP-seq
MIRT1936253	hsa-miR-4530	CLIP-seq
MIRT1936254	hsa-miR-646	CLIP-seq
MIRT1936245	hsa-miR-1265	CLIP-seq
MIRT1936247	hsa-miR-2355-5p	CLIP-seq
MIRT1936248	hsa-miR-2392	CLIP-seq
MIRT1936252	hsa-miR-4493	CLIP-seq
MIRT1936253	hsa-miR-4530	CLIP-seq
MIRT2675404	hsa-miR-513a-5p	CLIP-seq
MIRT1936254	hsa-miR-646	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9230079
GO:0005515	Function	Protein binding	IPI	25944859
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11741539
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	9230079
GO:0032355	Process	Response to estradiol	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0036284	Component	Tubulobulbar complex	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 604223
• HGNC: 704
• e!Ensembl: ENSG00000130429

Protein

• UniProt ID: O15143
• Protein name: Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)
• Protein function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin netwo
• PDB: 6UHC, 6YW6, 8P94
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	42 → 80	WD domain, G-beta repeat	Repeat
  PF00400	WD40	132 → 170	WD domain, G-beta repeat	Repeat

• Sequence:

  MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW
  APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI
  SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP
  APTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATL
  ASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARE
  RFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVK
  SLESALKDLKIK

• Sequence length: 372

Pathways

KEGG:

Endocytosis
Tight junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Reactome:

Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
ARPC1B-related disorder	Likely pathogenic; Pathogenic	rs1794611030	RCV003418257	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Combined immunodeficiency	Pathogenic	rs760191638	RCV001027546	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Inherited Immunodeficiency Diseases	Pathogenic	rs1584409386	RCV001027544	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease	Pathogenic; Likely pathogenic	rs779597975, rs2484628438, rs1794454006, rs1186149065, rs1584410808, rs760191638, rs1794516424, rs1794553748, rs111297226, rs371760619, rs1256029497, rs1794559320	RCV001332663 RCV005645448 RCV000513526 RCV000512862 RCV000987936 RCV001251027 RCV001251022 RCV001251023 RCV001251024 RCV001251025 RCV001251026 RCV001253464	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Squamous cell carcinoma of the head and neck	Pathogenic	rs779597975	RCV005911097	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Abnormal bleeding	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance; -	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMBINED IMMUNODEFICIENCY DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IMMUNODEFICIENCY 71 WITH INFLAMMATORY DISEASE AND CONGENITAL THROMBOCYTOPENIA	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombocytopenia	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	Pubtator	33679784	Associate	★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet-type bleeding disorder	GENOMICS_ENGLAND_DG	27965109		★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	28368018, 35163398	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27479355, 30971746		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	20345486	Associate	★☆☆☆☆ Found in Text Mining only
Combined immunodeficiency	Severe combined immunodeficiency disease	BEFREE	30254128, 31710310		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diabetes Mellitus	Diabetes mellitus	Pubtator	40718484	Associate	★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	Pubtator	31379835	Associate	★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	Pubtator	28368018, 35163398	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35111386, 35185876	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35111386	Associate	★☆☆☆☆ Found in Text Mining only
Lymphocytosis	Lymphocytosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27479355, 30971746		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	12115587		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	16723437		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26138391		★☆☆☆☆ Found in Text Mining only
Oligodendroglioma	Oligodendroglioma	Pubtator	29631562	Associate	★☆☆☆☆ Found in Text Mining only
PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASE	Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease	GENOMICS_ENGLAND_DG	27965109, 28368018		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASE	Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease	UNIPROT_DG	28368018		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASE	Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35163398	Associate	★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency	Pubtator	33679784	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	26138391		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	12115587		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	12115587		★☆☆☆☆ Found in Text Mining only
Thrombocytopenia	Thrombocytopenia	Pubtator	30254128, 33679784	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Uveal melanoma	Uveal melanoma	Pubtator	34630418	Associate	★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Wiskott-Aldrich Syndrome	Wiskott-Aldrich Syndrome	BEFREE	28368018		★☆☆☆☆ Found in Text Mining only