Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10094
Gene name	Actin related protein 2/3 complex subunit 3
Gene symbol	ARPC3
Synonyms (NCBI Gene)	ARC21p21-Arc
Chromosome	12
Chromosome location	12q24.11
Summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have

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Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020984	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT050237	hsa-miR-25-3p	CLASH	23622248
MIRT570301	hsa-miR-8084	PAR-CLIP	20371350
MIRT570299	hsa-miR-200b-3p	PAR-CLIP	20371350
MIRT570298	hsa-miR-200c-3p	PAR-CLIP	20371350
MIRT570297	hsa-miR-429	PAR-CLIP	20371350
MIRT570296	hsa-miR-4779	PAR-CLIP	20371350
MIRT570295	hsa-miR-6782-5p	PAR-CLIP	20371350
MIRT570294	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT570293	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT570292	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT570291	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT570290	hsa-miR-5194	PAR-CLIP	20371350
MIRT570289	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT570288	hsa-miR-765	PAR-CLIP	20371350
MIRT570287	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT570286	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT570284	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT570285	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT570283	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT570282	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT570281	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT570280	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT570279	hsa-miR-4651	PAR-CLIP	20371350
MIRT570278	hsa-miR-608	PAR-CLIP	20371350
MIRT570277	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT570275	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT570276	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT570274	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT570273	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT570272	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT570271	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT570270	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT570269	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT570268	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT570267	hsa-miR-3689c	PAR-CLIP	20371350
MIRT570266	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT570265	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT570264	hsa-miR-4534	PAR-CLIP	20371350
MIRT020984	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT020984	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT570301	hsa-miR-8084	PAR-CLIP	20371350
MIRT570299	hsa-miR-200b-3p	PAR-CLIP	20371350
MIRT570298	hsa-miR-200c-3p	PAR-CLIP	20371350
MIRT570297	hsa-miR-429	PAR-CLIP	20371350
MIRT570296	hsa-miR-4779	PAR-CLIP	20371350
MIRT570295	hsa-miR-6782-5p	PAR-CLIP	20371350
MIRT570294	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT570293	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT570292	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT570291	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT570290	hsa-miR-5194	PAR-CLIP	20371350
MIRT570289	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT570288	hsa-miR-765	PAR-CLIP	20371350
MIRT570287	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT570286	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT570284	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT570285	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT570283	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT570282	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT570281	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT570280	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT570279	hsa-miR-4651	PAR-CLIP	20371350
MIRT570278	hsa-miR-608	PAR-CLIP	20371350
MIRT570277	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT570275	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT570276	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT570274	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT570273	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT570272	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT570271	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT570270	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT570269	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT570268	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT570267	hsa-miR-3689c	PAR-CLIP	20371350
MIRT570266	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT570265	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT570264	hsa-miR-4534	PAR-CLIP	20371350
MIRT799753	hsa-miR-1	CLIP-seq
MIRT799754	hsa-miR-1297	CLIP-seq
MIRT799755	hsa-miR-1305	CLIP-seq
MIRT799756	hsa-miR-155	CLIP-seq
MIRT799757	hsa-miR-206	CLIP-seq
MIRT799758	hsa-miR-26a	CLIP-seq
MIRT799759	hsa-miR-26b	CLIP-seq
MIRT799760	hsa-miR-298	CLIP-seq
MIRT799761	hsa-miR-3158-5p	CLIP-seq
MIRT799762	hsa-miR-335	CLIP-seq
MIRT799763	hsa-miR-3617	CLIP-seq
MIRT799764	hsa-miR-3647-3p	CLIP-seq
MIRT799765	hsa-miR-3673	CLIP-seq
MIRT799766	hsa-miR-4282	CLIP-seq
MIRT799767	hsa-miR-4465	CLIP-seq
MIRT799768	hsa-miR-4477a	CLIP-seq
MIRT799769	hsa-miR-4795-3p	CLIP-seq
MIRT799770	hsa-miR-498	CLIP-seq
MIRT799771	hsa-miR-513a-3p	CLIP-seq
MIRT799772	hsa-miR-518e	CLIP-seq
MIRT799773	hsa-miR-548u	CLIP-seq
MIRT799774	hsa-miR-556-3p	CLIP-seq
MIRT799775	hsa-miR-613	CLIP-seq
MIRT799776	hsa-miR-641	CLIP-seq
MIRT1936263	hsa-miR-1273d	CLIP-seq
MIRT799760	hsa-miR-298	CLIP-seq
MIRT799761	hsa-miR-3158-5p	CLIP-seq
MIRT1936264	hsa-miR-3161	CLIP-seq
MIRT1936265	hsa-miR-3620	CLIP-seq
MIRT799764	hsa-miR-3647-3p	CLIP-seq
MIRT1936266	hsa-miR-3671	CLIP-seq
MIRT799766	hsa-miR-4282	CLIP-seq
MIRT799768	hsa-miR-4477a	CLIP-seq
MIRT1936267	hsa-miR-4762-5p	CLIP-seq
MIRT1936268	hsa-miR-4780	CLIP-seq
MIRT799771	hsa-miR-513a-3p	CLIP-seq
MIRT1936269	hsa-miR-607	CLIP-seq
MIRT2176106	hsa-miR-1236	CLIP-seq
MIRT799754	hsa-miR-1297	CLIP-seq
MIRT799755	hsa-miR-1305	CLIP-seq
MIRT799758	hsa-miR-26a	CLIP-seq
MIRT799759	hsa-miR-26b	CLIP-seq
MIRT2176107	hsa-miR-3163	CLIP-seq
MIRT2176108	hsa-miR-3182	CLIP-seq
MIRT799762	hsa-miR-335	CLIP-seq
MIRT799763	hsa-miR-3617	CLIP-seq
MIRT799764	hsa-miR-3647-3p	CLIP-seq
MIRT2176109	hsa-miR-3686	CLIP-seq
MIRT799766	hsa-miR-4282	CLIP-seq
MIRT799767	hsa-miR-4465	CLIP-seq
MIRT2176110	hsa-miR-4742-3p	CLIP-seq
MIRT2176111	hsa-miR-4768-5p	CLIP-seq
MIRT799770	hsa-miR-498	CLIP-seq
MIRT799771	hsa-miR-513a-3p	CLIP-seq
MIRT799773	hsa-miR-548u	CLIP-seq
MIRT2176112	hsa-miR-568	CLIP-seq
MIRT799776	hsa-miR-641	CLIP-seq
MIRT2176113	hsa-miR-942	CLIP-seq
MIRT799753	hsa-miR-1	CLIP-seq
MIRT2479473	hsa-miR-1224-3p	CLIP-seq
MIRT2479474	hsa-miR-1260	CLIP-seq
MIRT2479475	hsa-miR-1260b	CLIP-seq
MIRT2479476	hsa-miR-1280	CLIP-seq
MIRT2479477	hsa-miR-150	CLIP-seq
MIRT799756	hsa-miR-155	CLIP-seq
MIRT799757	hsa-miR-206	CLIP-seq
MIRT799760	hsa-miR-298	CLIP-seq
MIRT799761	hsa-miR-3158-5p	CLIP-seq
MIRT799764	hsa-miR-3647-3p	CLIP-seq
MIRT1936266	hsa-miR-3671	CLIP-seq
MIRT799765	hsa-miR-3673	CLIP-seq
MIRT799766	hsa-miR-4282	CLIP-seq
MIRT799768	hsa-miR-4477a	CLIP-seq
MIRT2479478	hsa-miR-4713-5p	CLIP-seq
MIRT799769	hsa-miR-4795-3p	CLIP-seq
MIRT799771	hsa-miR-513a-3p	CLIP-seq
MIRT799772	hsa-miR-518e	CLIP-seq
MIRT2479479	hsa-miR-532-3p	CLIP-seq
MIRT799774	hsa-miR-556-3p	CLIP-seq
MIRT1936269	hsa-miR-607	CLIP-seq
MIRT799775	hsa-miR-613	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9230079
GO:0005515	Function	Protein binding	IPI	11162547, 24981860, 25416956, 32296183, 33961781, 35271311, 36217029, 36217030
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11741539
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0015629	Component	Actin cytoskeleton	TAS	9230079
GO:0016020	Component	Membrane	HDA	19946888
GO:0030027	Component	Lamellipodium	IDA	9230079
GO:0030027	Component	Lamellipodium	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IEA
GO:0031252	Component	Cell leading edge	IEA
GO:0031941	Component	Filamentous actin	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0035861	Component	Site of double-strand break	ISS
GO:0042995	Component	Cell projection	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0061850	Component	Growth cone leading edge	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070358	Process	Actin polymerization-dependent cell motility	TAS	9230079
GO:1900242	Process	Regulation of synaptic vesicle endocytosis	IEA
GO:1990090	Process	Cellular response to nerve growth factor stimulus	IEA

MIM	HGNC	e!Ensembl
604225	706	ENSG00000111229

O15145

Protein name

Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)

Protein function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytopl

PDB

6UHC , 6YW6 , 6YW7 , 8P94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04062	P21-Arc	1 → 173	ARP2/3 complex ARPC3 (21 kDa) subunit	Family

Sequence

MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEI
KNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKP
ANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ

Sequence length

178

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Tight junction Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection		Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33960941	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	27055012		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	40616392	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Porokeratosis	Porokeratosis	BEFREE	19615027		★★★★★ ★☆☆☆☆ Found in Text Mining only
Porokeratosis of Mibelli	Porokeratosis	BEFREE	19615027		★★★★★ ★☆☆☆☆ Found in Text Mining only
Porokeratosis, Disseminated Superficial Actinic	Porokeratosis	BEFREE	15928614		★★★★★ ★☆☆☆☆ Found in Text Mining only

ARPC3 (actin related protein 2/3 complex subunit 3)