ARPC5 (actin related protein 2/3 complex subunit 5)

Gene

• Entrez ID: 10092
• Gene name: Actin related protein 2/3 complex subunit 5
• Gene symbol: ARPC5
• Synonyms (NCBI Gene): ARC16, IMD113, dJ127C7.3, p16-Arc
• Chromosome: 1
• Chromosome location: 1q25.3
• Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004981	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR	19524507
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	EMSA, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	EMSA, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22447776
MIRT006195	hsa-miR-22-3p	EMSA, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22447776
MIRT021283	hsa-miR-125a-5p	Sequencing	20371350
MIRT021705	hsa-miR-133a-3p	Microarray	21396852
MIRT024056	hsa-miR-1-3p	Proteomics	18668040
MIRT025613	hsa-miR-10a-5p	Sequencing	20371350
MIRT028673	hsa-miR-30a-5p	Proteomics	18668040
MIRT030269	hsa-miR-26b-5p	Microarray	19088304
MIRT021705	hsa-miR-133a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22378351
MIRT481477	hsa-miR-548n	PAR-CLIP	20371350
MIRT481476	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT481475	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT481474	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT481477	hsa-miR-548n	PAR-CLIP	23592263
MIRT481476	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT481475	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT481474	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT481477	hsa-miR-548n	PAR-CLIP	20371350
MIRT481476	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT481475	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT481474	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT481477	hsa-miR-548n	PAR-CLIP	23592263
MIRT481476	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT481475	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT481474	hsa-miR-495-5p	PAR-CLIP	23592263
MIRT755937	hsa-miR-133b	Luciferase reporter assay, Western blotting, in vitro cullelar assays	38069061
MIRT799891	hsa-miR-10a	CLIP-seq
MIRT799892	hsa-miR-10b	CLIP-seq
MIRT799893	hsa-miR-1256	CLIP-seq
MIRT799894	hsa-miR-125a-3p	CLIP-seq
MIRT799895	hsa-miR-1303	CLIP-seq
MIRT799896	hsa-miR-1323	CLIP-seq
MIRT799897	hsa-miR-141	CLIP-seq
MIRT799898	hsa-miR-145	CLIP-seq
MIRT799899	hsa-miR-190	CLIP-seq
MIRT799900	hsa-miR-190b	CLIP-seq
MIRT799901	hsa-miR-193a-3p	CLIP-seq
MIRT799902	hsa-miR-193b	CLIP-seq
MIRT799903	hsa-miR-200a	CLIP-seq
MIRT799904	hsa-miR-203	CLIP-seq
MIRT799905	hsa-miR-2052	CLIP-seq
MIRT799906	hsa-miR-2053	CLIP-seq
MIRT799907	hsa-miR-216b	CLIP-seq
MIRT799908	hsa-miR-22	CLIP-seq
MIRT799909	hsa-miR-224	CLIP-seq
MIRT799910	hsa-miR-2355-3p	CLIP-seq
MIRT799911	hsa-miR-3065-5p	CLIP-seq
MIRT799912	hsa-miR-30a	CLIP-seq
MIRT799913	hsa-miR-30b	CLIP-seq
MIRT799914	hsa-miR-30c	CLIP-seq
MIRT799915	hsa-miR-30d	CLIP-seq
MIRT799916	hsa-miR-30e	CLIP-seq
MIRT799917	hsa-miR-3145-3p	CLIP-seq
MIRT799918	hsa-miR-3176	CLIP-seq
MIRT799919	hsa-miR-3185	CLIP-seq
MIRT799920	hsa-miR-320a	CLIP-seq
MIRT799921	hsa-miR-320b	CLIP-seq
MIRT799922	hsa-miR-320c	CLIP-seq
MIRT799923	hsa-miR-320d	CLIP-seq
MIRT799924	hsa-miR-3612	CLIP-seq
MIRT799925	hsa-miR-3613-3p	CLIP-seq
MIRT799926	hsa-miR-3617	CLIP-seq
MIRT799927	hsa-miR-369-3p	CLIP-seq
MIRT799928	hsa-miR-374c	CLIP-seq
MIRT799929	hsa-miR-380	CLIP-seq
MIRT799930	hsa-miR-3922-3p	CLIP-seq
MIRT799931	hsa-miR-3934	CLIP-seq
MIRT799932	hsa-miR-3973	CLIP-seq
MIRT799933	hsa-miR-421	CLIP-seq
MIRT799934	hsa-miR-4256	CLIP-seq
MIRT799935	hsa-miR-4264	CLIP-seq
MIRT799936	hsa-miR-4272	CLIP-seq
MIRT799937	hsa-miR-4276	CLIP-seq
MIRT799938	hsa-miR-4328	CLIP-seq
MIRT799939	hsa-miR-4420	CLIP-seq
MIRT799940	hsa-miR-4429	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799942	hsa-miR-4436b-3p	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT799944	hsa-miR-4475	CLIP-seq
MIRT799945	hsa-miR-4477a	CLIP-seq
MIRT799946	hsa-miR-4495	CLIP-seq
MIRT799947	hsa-miR-4496	CLIP-seq
MIRT799948	hsa-miR-450b-5p	CLIP-seq
MIRT799949	hsa-miR-451b	CLIP-seq
MIRT799950	hsa-miR-4642	CLIP-seq
MIRT799951	hsa-miR-4646-3p	CLIP-seq
MIRT799952	hsa-miR-4659a-3p	CLIP-seq
MIRT799953	hsa-miR-4659b-3p	CLIP-seq
MIRT799954	hsa-miR-4670-3p	CLIP-seq
MIRT799955	hsa-miR-4695-5p	CLIP-seq
MIRT799956	hsa-miR-4697-3p	CLIP-seq
MIRT799957	hsa-miR-4720-5p	CLIP-seq
MIRT799958	hsa-miR-4733-5p	CLIP-seq
MIRT799959	hsa-miR-4738-3p	CLIP-seq
MIRT799960	hsa-miR-4757-5p	CLIP-seq
MIRT799961	hsa-miR-4762-3p	CLIP-seq
MIRT799962	hsa-miR-4762-5p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT799964	hsa-miR-4775	CLIP-seq
MIRT799965	hsa-miR-4797-3p	CLIP-seq
MIRT799966	hsa-miR-4799-3p	CLIP-seq
MIRT799967	hsa-miR-488	CLIP-seq
MIRT799968	hsa-miR-494	CLIP-seq
MIRT799969	hsa-miR-499-3p	CLIP-seq
MIRT799970	hsa-miR-499a-3p	CLIP-seq
MIRT799971	hsa-miR-507	CLIP-seq
MIRT799972	hsa-miR-509-3p	CLIP-seq
MIRT799973	hsa-miR-520d-5p	CLIP-seq
MIRT799974	hsa-miR-522	CLIP-seq
MIRT799975	hsa-miR-524-5p	CLIP-seq
MIRT799976	hsa-miR-548a-3p	CLIP-seq
MIRT799977	hsa-miR-548a-5p	CLIP-seq
MIRT799978	hsa-miR-548aa	CLIP-seq
MIRT799979	hsa-miR-548ab	CLIP-seq
MIRT799980	hsa-miR-548ac	CLIP-seq
MIRT799981	hsa-miR-548ak	CLIP-seq
MIRT799982	hsa-miR-548b-5p	CLIP-seq
MIRT799983	hsa-miR-548c-3p	CLIP-seq
MIRT799984	hsa-miR-548c-5p	CLIP-seq
MIRT799985	hsa-miR-548d-3p	CLIP-seq
MIRT799986	hsa-miR-548d-5p	CLIP-seq
MIRT799987	hsa-miR-548e	CLIP-seq
MIRT799988	hsa-miR-548f	CLIP-seq
MIRT799989	hsa-miR-548h	CLIP-seq
MIRT799990	hsa-miR-548i	CLIP-seq
MIRT799991	hsa-miR-548j	CLIP-seq
MIRT799992	hsa-miR-548o	CLIP-seq
MIRT799993	hsa-miR-548p	CLIP-seq
MIRT799994	hsa-miR-548t	CLIP-seq
MIRT799995	hsa-miR-548w	CLIP-seq
MIRT799996	hsa-miR-548y	CLIP-seq
MIRT799997	hsa-miR-548z	CLIP-seq
MIRT799998	hsa-miR-549	CLIP-seq
MIRT799999	hsa-miR-556-5p	CLIP-seq
MIRT800000	hsa-miR-557	CLIP-seq
MIRT800001	hsa-miR-559	CLIP-seq
MIRT800002	hsa-miR-569	CLIP-seq
MIRT800003	hsa-miR-590-3p	CLIP-seq
MIRT800004	hsa-miR-610	CLIP-seq
MIRT800005	hsa-miR-633	CLIP-seq
MIRT800006	hsa-miR-641	CLIP-seq
MIRT800007	hsa-miR-642a	CLIP-seq
MIRT800008	hsa-miR-650	CLIP-seq
MIRT800009	hsa-miR-655	CLIP-seq
MIRT800010	hsa-miR-656	CLIP-seq
MIRT800011	hsa-miR-659	CLIP-seq
MIRT800012	hsa-miR-764	CLIP-seq
MIRT800013	hsa-miR-876-3p	CLIP-seq
MIRT800014	hsa-miR-885-3p	CLIP-seq
MIRT799905	hsa-miR-2052	CLIP-seq
MIRT799917	hsa-miR-3145-3p	CLIP-seq
MIRT799924	hsa-miR-3612	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT799952	hsa-miR-4659a-3p	CLIP-seq
MIRT799953	hsa-miR-4659b-3p	CLIP-seq
MIRT799955	hsa-miR-4695-5p	CLIP-seq
MIRT799958	hsa-miR-4733-5p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT799967	hsa-miR-488	CLIP-seq
MIRT799993	hsa-miR-548p	CLIP-seq
MIRT800008	hsa-miR-650	CLIP-seq
MIRT800010	hsa-miR-656	CLIP-seq
MIRT799958	hsa-miR-4733-5p	CLIP-seq
MIRT1936275	hsa-miR-1179	CLIP-seq
MIRT1936276	hsa-miR-1260	CLIP-seq
MIRT1936277	hsa-miR-1260b	CLIP-seq
MIRT1936278	hsa-miR-1298	CLIP-seq
MIRT799896	hsa-miR-1323	CLIP-seq
MIRT799898	hsa-miR-145	CLIP-seq
MIRT1936279	hsa-miR-1827	CLIP-seq
MIRT1936280	hsa-miR-188-3p	CLIP-seq
MIRT799904	hsa-miR-203	CLIP-seq
MIRT799905	hsa-miR-2052	CLIP-seq
MIRT799909	hsa-miR-224	CLIP-seq
MIRT1936281	hsa-miR-3120-3p	CLIP-seq
MIRT1936282	hsa-miR-3130-3p	CLIP-seq
MIRT799917	hsa-miR-3145-3p	CLIP-seq
MIRT1936283	hsa-miR-3156-3p	CLIP-seq
MIRT799925	hsa-miR-3613-3p	CLIP-seq
MIRT1936284	hsa-miR-4257	CLIP-seq
MIRT799937	hsa-miR-4276	CLIP-seq
MIRT1936285	hsa-miR-4301	CLIP-seq
MIRT799938	hsa-miR-4328	CLIP-seq
MIRT799939	hsa-miR-4420	CLIP-seq
MIRT1936286	hsa-miR-4436b-5p	CLIP-seq
MIRT799946	hsa-miR-4495	CLIP-seq
MIRT799948	hsa-miR-450b-5p	CLIP-seq
MIRT799950	hsa-miR-4642	CLIP-seq
MIRT799952	hsa-miR-4659a-3p	CLIP-seq
MIRT799953	hsa-miR-4659b-3p	CLIP-seq
MIRT799954	hsa-miR-4670-3p	CLIP-seq
MIRT799956	hsa-miR-4697-3p	CLIP-seq
MIRT799957	hsa-miR-4720-5p	CLIP-seq
MIRT1936287	hsa-miR-4740-3p	CLIP-seq
MIRT799961	hsa-miR-4762-3p	CLIP-seq
MIRT1936288	hsa-miR-4793-3p	CLIP-seq
MIRT799966	hsa-miR-4799-3p	CLIP-seq
MIRT1936289	hsa-miR-485-5p	CLIP-seq
MIRT799967	hsa-miR-488	CLIP-seq
MIRT799968	hsa-miR-494	CLIP-seq
MIRT799969	hsa-miR-499-3p	CLIP-seq
MIRT799970	hsa-miR-499a-3p	CLIP-seq
MIRT799971	hsa-miR-507	CLIP-seq
MIRT799973	hsa-miR-520d-5p	CLIP-seq
MIRT799974	hsa-miR-522	CLIP-seq
MIRT799975	hsa-miR-524-5p	CLIP-seq
MIRT1936290	hsa-miR-544	CLIP-seq
MIRT1936291	hsa-miR-545	CLIP-seq
MIRT799976	hsa-miR-548a-3p	CLIP-seq
MIRT799987	hsa-miR-548e	CLIP-seq
MIRT799988	hsa-miR-548f	CLIP-seq
MIRT799992	hsa-miR-548o	CLIP-seq
MIRT800000	hsa-miR-557	CLIP-seq
MIRT1936292	hsa-miR-634	CLIP-seq
MIRT2176136	hsa-miR-124	CLIP-seq
MIRT1936276	hsa-miR-1260	CLIP-seq
MIRT1936277	hsa-miR-1260b	CLIP-seq
MIRT1936280	hsa-miR-188-3p	CLIP-seq
MIRT799904	hsa-miR-203	CLIP-seq
MIRT799905	hsa-miR-2052	CLIP-seq
MIRT799906	hsa-miR-2053	CLIP-seq
MIRT1936282	hsa-miR-3130-3p	CLIP-seq
MIRT2176137	hsa-miR-3144-3p	CLIP-seq
MIRT1936283	hsa-miR-3156-3p	CLIP-seq
MIRT799924	hsa-miR-3612	CLIP-seq
MIRT2176138	hsa-miR-3714	CLIP-seq
MIRT2176139	hsa-miR-3910	CLIP-seq
MIRT2176140	hsa-miR-3923	CLIP-seq
MIRT1936285	hsa-miR-4301	CLIP-seq
MIRT799938	hsa-miR-4328	CLIP-seq
MIRT799939	hsa-miR-4420	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT2176141	hsa-miR-4521	CLIP-seq
MIRT799955	hsa-miR-4695-5p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT2176142	hsa-miR-4777-3p	CLIP-seq
MIRT1936288	hsa-miR-4793-3p	CLIP-seq
MIRT799967	hsa-miR-488	CLIP-seq
MIRT799968	hsa-miR-494	CLIP-seq
MIRT799969	hsa-miR-499-3p	CLIP-seq
MIRT799970	hsa-miR-499a-3p	CLIP-seq
MIRT2176143	hsa-miR-506	CLIP-seq
MIRT799971	hsa-miR-507	CLIP-seq
MIRT799972	hsa-miR-509-3p	CLIP-seq
MIRT799974	hsa-miR-522	CLIP-seq
MIRT1936290	hsa-miR-544	CLIP-seq
MIRT799993	hsa-miR-548p	CLIP-seq
MIRT800000	hsa-miR-557	CLIP-seq
MIRT2176144	hsa-miR-568	CLIP-seq
MIRT800002	hsa-miR-569	CLIP-seq
MIRT800005	hsa-miR-633	CLIP-seq
MIRT1936292	hsa-miR-634	CLIP-seq
MIRT800008	hsa-miR-650	CLIP-seq
MIRT800010	hsa-miR-656	CLIP-seq
MIRT800011	hsa-miR-659	CLIP-seq
MIRT2176145	hsa-miR-767-5p	CLIP-seq
MIRT2176146	hsa-miR-875-5p	CLIP-seq
MIRT800007	hsa-miR-642a	CLIP-seq
MIRT800011	hsa-miR-659	CLIP-seq
MIRT2426486	hsa-miR-101	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT799954	hsa-miR-4670-3p	CLIP-seq
MIRT799961	hsa-miR-4762-3p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT2426486	hsa-miR-101	CLIP-seq
MIRT799894	hsa-miR-125a-3p	CLIP-seq
MIRT2479507	hsa-miR-129-5p	CLIP-seq
MIRT799895	hsa-miR-1303	CLIP-seq
MIRT2479508	hsa-miR-146a	CLIP-seq
MIRT2479509	hsa-miR-146b-5p	CLIP-seq
MIRT799899	hsa-miR-190	CLIP-seq
MIRT799900	hsa-miR-190b	CLIP-seq
MIRT799909	hsa-miR-224	CLIP-seq
MIRT799910	hsa-miR-2355-3p	CLIP-seq
MIRT799911	hsa-miR-3065-5p	CLIP-seq
MIRT1936281	hsa-miR-3120-3p	CLIP-seq
MIRT1936282	hsa-miR-3130-3p	CLIP-seq
MIRT799917	hsa-miR-3145-3p	CLIP-seq
MIRT799924	hsa-miR-3612	CLIP-seq
MIRT799925	hsa-miR-3613-3p	CLIP-seq
MIRT2479510	hsa-miR-3646	CLIP-seq
MIRT2479511	hsa-miR-3662	CLIP-seq
MIRT799929	hsa-miR-380	CLIP-seq
MIRT799931	hsa-miR-3934	CLIP-seq
MIRT799932	hsa-miR-3973	CLIP-seq
MIRT2479512	hsa-miR-4274	CLIP-seq
MIRT799937	hsa-miR-4276	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT799946	hsa-miR-4495	CLIP-seq
MIRT2479513	hsa-miR-4519	CLIP-seq
MIRT799949	hsa-miR-451b	CLIP-seq
MIRT2479514	hsa-miR-4524	CLIP-seq
MIRT799950	hsa-miR-4642	CLIP-seq
MIRT799951	hsa-miR-4646-3p	CLIP-seq
MIRT799954	hsa-miR-4670-3p	CLIP-seq
MIRT799955	hsa-miR-4695-5p	CLIP-seq
MIRT799956	hsa-miR-4697-3p	CLIP-seq
MIRT2479515	hsa-miR-4698	CLIP-seq
MIRT799961	hsa-miR-4762-3p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT799964	hsa-miR-4775	CLIP-seq
MIRT1936288	hsa-miR-4793-3p	CLIP-seq
MIRT799968	hsa-miR-494	CLIP-seq
MIRT799971	hsa-miR-507	CLIP-seq
MIRT799973	hsa-miR-520d-5p	CLIP-seq
MIRT799975	hsa-miR-524-5p	CLIP-seq
MIRT1936290	hsa-miR-544	CLIP-seq
MIRT1936291	hsa-miR-545	CLIP-seq
MIRT799977	hsa-miR-548a-5p	CLIP-seq
MIRT799979	hsa-miR-548ab	CLIP-seq
MIRT799981	hsa-miR-548ak	CLIP-seq
MIRT799982	hsa-miR-548b-5p	CLIP-seq
MIRT799984	hsa-miR-548c-5p	CLIP-seq
MIRT799986	hsa-miR-548d-5p	CLIP-seq
MIRT799989	hsa-miR-548h	CLIP-seq
MIRT799990	hsa-miR-548i	CLIP-seq
MIRT799991	hsa-miR-548j	CLIP-seq
MIRT799993	hsa-miR-548p	CLIP-seq
MIRT799995	hsa-miR-548w	CLIP-seq
MIRT799996	hsa-miR-548y	CLIP-seq
MIRT800000	hsa-miR-557	CLIP-seq
MIRT800001	hsa-miR-559	CLIP-seq
MIRT2479516	hsa-miR-580	CLIP-seq
MIRT2479517	hsa-miR-589	CLIP-seq
MIRT800003	hsa-miR-590-3p	CLIP-seq
MIRT800007	hsa-miR-642a	CLIP-seq
MIRT800008	hsa-miR-650	CLIP-seq
MIRT800011	hsa-miR-659	CLIP-seq
MIRT800012	hsa-miR-764	CLIP-seq
MIRT2176145	hsa-miR-767-5p	CLIP-seq
MIRT800013	hsa-miR-876-3p	CLIP-seq
MIRT2426486	hsa-miR-101	CLIP-seq
MIRT799894	hsa-miR-125a-3p	CLIP-seq
MIRT2479507	hsa-miR-129-5p	CLIP-seq
MIRT799895	hsa-miR-1303	CLIP-seq
MIRT2479508	hsa-miR-146a	CLIP-seq
MIRT2479509	hsa-miR-146b-5p	CLIP-seq
MIRT799899	hsa-miR-190	CLIP-seq
MIRT799900	hsa-miR-190b	CLIP-seq
MIRT799910	hsa-miR-2355-3p	CLIP-seq
MIRT1936281	hsa-miR-3120-3p	CLIP-seq
MIRT1936282	hsa-miR-3130-3p	CLIP-seq
MIRT799917	hsa-miR-3145-3p	CLIP-seq
MIRT799924	hsa-miR-3612	CLIP-seq
MIRT799925	hsa-miR-3613-3p	CLIP-seq
MIRT2479510	hsa-miR-3646	CLIP-seq
MIRT2479511	hsa-miR-3662	CLIP-seq
MIRT799929	hsa-miR-380	CLIP-seq
MIRT799931	hsa-miR-3934	CLIP-seq
MIRT2479512	hsa-miR-4274	CLIP-seq
MIRT799941	hsa-miR-4433	CLIP-seq
MIRT799943	hsa-miR-4459	CLIP-seq
MIRT799946	hsa-miR-4495	CLIP-seq
MIRT2479513	hsa-miR-4519	CLIP-seq
MIRT2479514	hsa-miR-4524	CLIP-seq
MIRT799950	hsa-miR-4642	CLIP-seq
MIRT799951	hsa-miR-4646-3p	CLIP-seq
MIRT799954	hsa-miR-4670-3p	CLIP-seq
MIRT799955	hsa-miR-4695-5p	CLIP-seq
MIRT2479515	hsa-miR-4698	CLIP-seq
MIRT799961	hsa-miR-4762-3p	CLIP-seq
MIRT799963	hsa-miR-4768-3p	CLIP-seq
MIRT799964	hsa-miR-4775	CLIP-seq
MIRT1936288	hsa-miR-4793-3p	CLIP-seq
MIRT799968	hsa-miR-494	CLIP-seq
MIRT799971	hsa-miR-507	CLIP-seq
MIRT799973	hsa-miR-520d-5p	CLIP-seq
MIRT799975	hsa-miR-524-5p	CLIP-seq
MIRT1936290	hsa-miR-544	CLIP-seq
MIRT1936291	hsa-miR-545	CLIP-seq
MIRT799993	hsa-miR-548p	CLIP-seq
MIRT800000	hsa-miR-557	CLIP-seq
MIRT2479516	hsa-miR-580	CLIP-seq
MIRT2479517	hsa-miR-589	CLIP-seq
MIRT800003	hsa-miR-590-3p	CLIP-seq
MIRT800007	hsa-miR-642a	CLIP-seq
MIRT800008	hsa-miR-650	CLIP-seq
MIRT800011	hsa-miR-659	CLIP-seq
MIRT800012	hsa-miR-764	CLIP-seq
MIRT2176145	hsa-miR-767-5p	CLIP-seq
MIRT800013	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11741539
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9230079
GO:0005515	Function	Protein binding	IPI	11162547
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	37349293
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9359840
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005885	Component	Arp2/3 protein complex	IBA
GO:0005885	Component	Arp2/3 protein complex	IDA	11741539
GO:0005885	Component	Arp2/3 protein complex	IEA
GO:0005885	Component	Arp2/3 protein complex	TAS	9230079
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	TAS	9230079
GO:0016477	Process	Cell migration	IBA
GO:0016477	Process	Cell migration	IMP	22378351
GO:0030027	Component	Lamellipodium	IEA
GO:0030036	Process	Actin cytoskeleton organization	TAS	9359840
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0030833	Process	Regulation of actin filament polymerization	IEA
GO:0030863	Component	Cortical cytoskeleton	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IBA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	11741539
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0035861	Component	Site of double-strand break	ISS
GO:0042995	Component	Cell projection	IEA
GO:0051015	Function	Actin filament binding	IDA	11741539
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 604227
• HGNC: 708
• e!Ensembl: ENSG00000162704

Protein

• UniProt ID: O15511
• Protein name: Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
• Protein function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytopl
• PDB: 6UHC, 6YW7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04699	P16-Arc	10 → 151	ARP2/3 complex 16 kDa subunit (p16-Arc)	Domain

• Sequence:

  MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALK
  NPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDN
  SSAMLLQWHEKALAAGGVGSIVRVLTARKTV

• Sequence length: 151

Pathways

KEGG:

Endocytosis
Tight junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection

Reactome:

Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation
Clathrin-mediated endocytosis
FCGR3A-mediated phagocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Immunodeficiency 113 with autoimmunity and autoinflammation	Pathogenic	rs1287691422, rs2528118860	RCV003444098 RCV003444099	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrial Fibrillation	Atrial fibrillation	Pubtator	36653368	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36148220	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37789267	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22378351		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	34468072	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	30201948		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	30201948, 37231521	Associate	★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal Diseases	BEFREE	29610270		★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal disease	Pubtator	29610270	Associate	★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	20956521		★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	20956521	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	22089643		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	22378351		★☆☆☆☆ Found in Text Mining only