Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10072
Gene name	Dipeptidyl peptidase 3
Gene symbol	DPP3
Synonyms (NCBI Gene)	DPPIII
Chromosome	11
Chromosome location	11q13.2
Summary	This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides

210

Show/Hide all (210)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044782	hsa-miR-320a	CLASH	23622248
MIRT040357	hsa-miR-615-3p	CLASH	23622248
MIRT036150	hsa-miR-1296-5p	CLASH	23622248
MIRT944167	hsa-let-7a	CLIP-seq
MIRT944168	hsa-let-7b	CLIP-seq
MIRT944169	hsa-let-7c	CLIP-seq
MIRT944170	hsa-let-7d	CLIP-seq
MIRT944171	hsa-let-7e	CLIP-seq
MIRT944172	hsa-let-7f	CLIP-seq
MIRT944173	hsa-let-7g	CLIP-seq
MIRT944174	hsa-let-7i	CLIP-seq
MIRT944175	hsa-miR-1207-3p	CLIP-seq
MIRT944176	hsa-miR-1231	CLIP-seq
MIRT944177	hsa-miR-196a	CLIP-seq
MIRT944178	hsa-miR-196b	CLIP-seq
MIRT944179	hsa-miR-197	CLIP-seq
MIRT944180	hsa-miR-202	CLIP-seq
MIRT944181	hsa-miR-3163	CLIP-seq
MIRT944182	hsa-miR-3179	CLIP-seq
MIRT944183	hsa-miR-3202	CLIP-seq
MIRT944184	hsa-miR-340	CLIP-seq
MIRT944185	hsa-miR-3936	CLIP-seq
MIRT944186	hsa-miR-4282	CLIP-seq
MIRT944187	hsa-miR-4288	CLIP-seq
MIRT944188	hsa-miR-4458	CLIP-seq
MIRT944189	hsa-miR-4500	CLIP-seq
MIRT944190	hsa-miR-4517	CLIP-seq
MIRT944191	hsa-miR-4533	CLIP-seq
MIRT944192	hsa-miR-4694-3p	CLIP-seq
MIRT944193	hsa-miR-592	CLIP-seq
MIRT944194	hsa-miR-597	CLIP-seq
MIRT944195	hsa-miR-599	CLIP-seq
MIRT944196	hsa-miR-632	CLIP-seq
MIRT944197	hsa-miR-889	CLIP-seq
MIRT944198	hsa-miR-98	CLIP-seq
MIRT944167	hsa-let-7a	CLIP-seq
MIRT944168	hsa-let-7b	CLIP-seq
MIRT944169	hsa-let-7c	CLIP-seq
MIRT944170	hsa-let-7d	CLIP-seq
MIRT944171	hsa-let-7e	CLIP-seq
MIRT944172	hsa-let-7f	CLIP-seq
MIRT944173	hsa-let-7g	CLIP-seq
MIRT944174	hsa-let-7i	CLIP-seq
MIRT944175	hsa-miR-1207-3p	CLIP-seq
MIRT944199	hsa-miR-1913	CLIP-seq
MIRT944177	hsa-miR-196a	CLIP-seq
MIRT944178	hsa-miR-196b	CLIP-seq
MIRT944179	hsa-miR-197	CLIP-seq
MIRT944200	hsa-miR-1976	CLIP-seq
MIRT944180	hsa-miR-202	CLIP-seq
MIRT944201	hsa-miR-2355-5p	CLIP-seq
MIRT944182	hsa-miR-3179	CLIP-seq
MIRT944183	hsa-miR-3202	CLIP-seq
MIRT944202	hsa-miR-324-3p	CLIP-seq
MIRT944203	hsa-miR-329	CLIP-seq
MIRT944204	hsa-miR-362-3p	CLIP-seq
MIRT944185	hsa-miR-3936	CLIP-seq
MIRT944205	hsa-miR-3941	CLIP-seq
MIRT944188	hsa-miR-4458	CLIP-seq
MIRT944189	hsa-miR-4500	CLIP-seq
MIRT944191	hsa-miR-4533	CLIP-seq
MIRT944192	hsa-miR-4694-3p	CLIP-seq
MIRT944206	hsa-miR-4722-3p	CLIP-seq
MIRT944207	hsa-miR-4749-3p	CLIP-seq
MIRT944208	hsa-miR-4802-5p	CLIP-seq
MIRT944193	hsa-miR-592	CLIP-seq
MIRT944194	hsa-miR-597	CLIP-seq
MIRT944195	hsa-miR-599	CLIP-seq
MIRT944209	hsa-miR-603	CLIP-seq
MIRT944198	hsa-miR-98	CLIP-seq
MIRT944167	hsa-let-7a	CLIP-seq
MIRT944168	hsa-let-7b	CLIP-seq
MIRT944169	hsa-let-7c	CLIP-seq
MIRT944170	hsa-let-7d	CLIP-seq
MIRT944171	hsa-let-7e	CLIP-seq
MIRT944172	hsa-let-7f	CLIP-seq
MIRT944173	hsa-let-7g	CLIP-seq
MIRT944174	hsa-let-7i	CLIP-seq
MIRT1979568	hsa-miR-1193	CLIP-seq
MIRT944175	hsa-miR-1207-3p	CLIP-seq
MIRT944176	hsa-miR-1231	CLIP-seq
MIRT1979569	hsa-miR-1238	CLIP-seq
MIRT1979570	hsa-miR-1294	CLIP-seq
MIRT944199	hsa-miR-1913	CLIP-seq
MIRT944177	hsa-miR-196a	CLIP-seq
MIRT944178	hsa-miR-196b	CLIP-seq
MIRT944179	hsa-miR-197	CLIP-seq
MIRT944200	hsa-miR-1976	CLIP-seq
MIRT944180	hsa-miR-202	CLIP-seq
MIRT944201	hsa-miR-2355-5p	CLIP-seq
MIRT1979571	hsa-miR-2392	CLIP-seq
MIRT1979572	hsa-miR-3150b-3p	CLIP-seq
MIRT944181	hsa-miR-3163	CLIP-seq
MIRT944182	hsa-miR-3179	CLIP-seq
MIRT944183	hsa-miR-3202	CLIP-seq
MIRT1979573	hsa-miR-323b-5p	CLIP-seq
MIRT944202	hsa-miR-324-3p	CLIP-seq
MIRT944203	hsa-miR-329	CLIP-seq
MIRT944184	hsa-miR-340	CLIP-seq
MIRT1979574	hsa-miR-3529	CLIP-seq
MIRT944204	hsa-miR-362-3p	CLIP-seq
MIRT1979575	hsa-miR-379	CLIP-seq
MIRT944185	hsa-miR-3936	CLIP-seq
MIRT944205	hsa-miR-3941	CLIP-seq
MIRT944186	hsa-miR-4282	CLIP-seq
MIRT944187	hsa-miR-4288	CLIP-seq
MIRT1979576	hsa-miR-4316	CLIP-seq
MIRT1979577	hsa-miR-4451	CLIP-seq
MIRT944188	hsa-miR-4458	CLIP-seq
MIRT1979578	hsa-miR-4490	CLIP-seq
MIRT944189	hsa-miR-4500	CLIP-seq
MIRT1979579	hsa-miR-4501	CLIP-seq
MIRT944190	hsa-miR-4517	CLIP-seq
MIRT944191	hsa-miR-4533	CLIP-seq
MIRT1979580	hsa-miR-4650-3p	CLIP-seq
MIRT1979581	hsa-miR-4689	CLIP-seq
MIRT944192	hsa-miR-4694-3p	CLIP-seq
MIRT944206	hsa-miR-4722-3p	CLIP-seq
MIRT944207	hsa-miR-4749-3p	CLIP-seq
MIRT1979582	hsa-miR-4774-5p	CLIP-seq
MIRT1979583	hsa-miR-4784	CLIP-seq
MIRT944193	hsa-miR-592	CLIP-seq
MIRT1979584	hsa-miR-593	CLIP-seq
MIRT944194	hsa-miR-597	CLIP-seq
MIRT944195	hsa-miR-599	CLIP-seq
MIRT944209	hsa-miR-603	CLIP-seq
MIRT944196	hsa-miR-632	CLIP-seq
MIRT944197	hsa-miR-889	CLIP-seq
MIRT944198	hsa-miR-98	CLIP-seq
MIRT2214660	hsa-miR-1178	CLIP-seq
MIRT1979568	hsa-miR-1193	CLIP-seq
MIRT2214661	hsa-miR-146b-3p	CLIP-seq
MIRT2214662	hsa-miR-183	CLIP-seq
MIRT1979571	hsa-miR-2392	CLIP-seq
MIRT2214663	hsa-miR-339-5p	CLIP-seq
MIRT1979574	hsa-miR-3529	CLIP-seq
MIRT1979575	hsa-miR-379	CLIP-seq
MIRT2214664	hsa-miR-431	CLIP-seq
MIRT2214665	hsa-miR-4421	CLIP-seq
MIRT1979577	hsa-miR-4451	CLIP-seq
MIRT1979578	hsa-miR-4490	CLIP-seq
MIRT1979580	hsa-miR-4650-3p	CLIP-seq
MIRT1979582	hsa-miR-4774-5p	CLIP-seq
MIRT2214666	hsa-miR-483-3p	CLIP-seq
MIRT2214660	hsa-miR-1178	CLIP-seq
MIRT1979568	hsa-miR-1193	CLIP-seq
MIRT2519056	hsa-miR-1227	CLIP-seq
MIRT1979569	hsa-miR-1238	CLIP-seq
MIRT2519057	hsa-miR-1245b-3p	CLIP-seq
MIRT2214661	hsa-miR-146b-3p	CLIP-seq
MIRT2519058	hsa-miR-148a	CLIP-seq
MIRT2519059	hsa-miR-148b	CLIP-seq
MIRT2519060	hsa-miR-152	CLIP-seq
MIRT2214662	hsa-miR-183	CLIP-seq
MIRT2519061	hsa-miR-203	CLIP-seq
MIRT1979571	hsa-miR-2392	CLIP-seq
MIRT2519062	hsa-miR-3164	CLIP-seq
MIRT2214663	hsa-miR-339-5p	CLIP-seq
MIRT2519063	hsa-miR-34a	CLIP-seq
MIRT2519064	hsa-miR-34c-5p	CLIP-seq
MIRT1979574	hsa-miR-3529	CLIP-seq
MIRT1979575	hsa-miR-379	CLIP-seq
MIRT2519065	hsa-miR-4305	CLIP-seq
MIRT2214664	hsa-miR-431	CLIP-seq
MIRT2519066	hsa-miR-4330	CLIP-seq
MIRT2214665	hsa-miR-4421	CLIP-seq
MIRT1979577	hsa-miR-4451	CLIP-seq
MIRT1979578	hsa-miR-4490	CLIP-seq
MIRT2519067	hsa-miR-449a	CLIP-seq
MIRT2519068	hsa-miR-449b	CLIP-seq
MIRT1979580	hsa-miR-4650-3p	CLIP-seq
MIRT2519069	hsa-miR-4715-3p	CLIP-seq
MIRT2519070	hsa-miR-4734	CLIP-seq
MIRT2519071	hsa-miR-4769-3p	CLIP-seq
MIRT1979582	hsa-miR-4774-5p	CLIP-seq
MIRT2214666	hsa-miR-483-3p	CLIP-seq
MIRT2519072	hsa-miR-617	CLIP-seq
MIRT2214660	hsa-miR-1178	CLIP-seq
MIRT1979568	hsa-miR-1193	CLIP-seq
MIRT2519056	hsa-miR-1227	CLIP-seq
MIRT1979569	hsa-miR-1238	CLIP-seq
MIRT2519057	hsa-miR-1245b-3p	CLIP-seq
MIRT2214661	hsa-miR-146b-3p	CLIP-seq
MIRT2519058	hsa-miR-148a	CLIP-seq
MIRT2519059	hsa-miR-148b	CLIP-seq
MIRT2519060	hsa-miR-152	CLIP-seq
MIRT2214662	hsa-miR-183	CLIP-seq
MIRT2519061	hsa-miR-203	CLIP-seq
MIRT1979571	hsa-miR-2392	CLIP-seq
MIRT2519062	hsa-miR-3164	CLIP-seq
MIRT2214663	hsa-miR-339-5p	CLIP-seq
MIRT2519063	hsa-miR-34a	CLIP-seq
MIRT2519064	hsa-miR-34c-5p	CLIP-seq
MIRT1979574	hsa-miR-3529	CLIP-seq
MIRT1979575	hsa-miR-379	CLIP-seq
MIRT2519065	hsa-miR-4305	CLIP-seq
MIRT2214664	hsa-miR-431	CLIP-seq
MIRT2519066	hsa-miR-4330	CLIP-seq
MIRT2214665	hsa-miR-4421	CLIP-seq
MIRT1979577	hsa-miR-4451	CLIP-seq
MIRT1979578	hsa-miR-4490	CLIP-seq
MIRT2519067	hsa-miR-449a	CLIP-seq
MIRT2519068	hsa-miR-449b	CLIP-seq
MIRT1979580	hsa-miR-4650-3p	CLIP-seq
MIRT2519069	hsa-miR-4715-3p	CLIP-seq
MIRT2519070	hsa-miR-4734	CLIP-seq
MIRT2519071	hsa-miR-4769-3p	CLIP-seq
MIRT1979582	hsa-miR-4774-5p	CLIP-seq
MIRT2214666	hsa-miR-483-3p	CLIP-seq
MIRT2519072	hsa-miR-617	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	19615732, 21516116, 25416956, 32296183, 33961781, 34591642
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0006508	Process	Proteolysis	IDA	9425109, 10387075
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008235	Function	Metalloexopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008239	Function	Dipeptidyl-peptidase activity	IBA
GO:0008239	Function	Dipeptidyl-peptidase activity	IDA	9425109, 10387075
GO:0008239	Function	Dipeptidyl-peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	9425109, 10387075
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
606818	3008	ENSG00000254986

Q9NY33

Protein name

Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)

Protein function

Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:000026

PDB

3FVY , 3T6B , 3T6J , 5E2Q , 5E33 , 5E3A , 5E3C , 5EGY , 5EHH , 7OUP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03571	Peptidase_M49	143 → 704	Peptidase family M49	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063). {ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187}.

Sequence

MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIY
ALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPK
EKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMED
AKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFR
GSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW
IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWP
PTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQ
REKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPE
TGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIY
VNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPD
ARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRD
TVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLAT
ADARFWKGPSEAPSGQA

Sequence length

737

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	28416489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28416489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	31472040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	37531267	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20236318, 24472318		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20236318, 24472318	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20236318, 24472318		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	31472040		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28416489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23382044, 28416489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23382044		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	28416489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	31295380		★★★★★ ★☆☆☆☆ Found in Text Mining only

DPP3 (dipeptidyl peptidase 3)