RWDD2B (RWD domain containing 2B)

Gene

• Entrez ID: 10069
• Gene name: RWD domain containing 2B
• Gene symbol: RWDD2B
• Synonyms (NCBI Gene): C21orf6, GL011
• Chromosome: 21
• Chromosome location: 21q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1323194	hsa-miR-29a	CLIP-seq
MIRT1323195	hsa-miR-29b	CLIP-seq
MIRT1323196	hsa-miR-29c	CLIP-seq
MIRT1323197	hsa-miR-3128	CLIP-seq
MIRT1323198	hsa-miR-3160-5p	CLIP-seq
MIRT1323199	hsa-miR-323-3p	CLIP-seq
MIRT1323200	hsa-miR-3663-3p	CLIP-seq
MIRT1323201	hsa-miR-4277	CLIP-seq
MIRT1323202	hsa-miR-4470	CLIP-seq
MIRT1323203	hsa-miR-4705	CLIP-seq
MIRT2095870	hsa-miR-1246	CLIP-seq
MIRT739571	hsa-miR-22	CLIP-seq
MIRT1323198	hsa-miR-3160-5p	CLIP-seq
MIRT2095871	hsa-miR-3591-5p	CLIP-seq
MIRT2095872	hsa-miR-3606	CLIP-seq
MIRT2095873	hsa-miR-3689d	CLIP-seq
MIRT2095874	hsa-miR-3936	CLIP-seq
MIRT1323201	hsa-miR-4277	CLIP-seq
MIRT739570	hsa-miR-448	CLIP-seq
MIRT1323203	hsa-miR-4705	CLIP-seq
MIRT2095875	hsa-miR-4723-5p	CLIP-seq
MIRT2095876	hsa-miR-548n	CLIP-seq
MIRT2095877	hsa-miR-548t	CLIP-seq
MIRT2095878	hsa-miR-586	CLIP-seq
MIRT2095879	hsa-miR-765	CLIP-seq
MIRT2095880	hsa-miR-921	CLIP-seq
MIRT1323194	hsa-miR-29a	CLIP-seq
MIRT1323195	hsa-miR-29b	CLIP-seq
MIRT1323196	hsa-miR-29c	CLIP-seq
MIRT1323200	hsa-miR-3663-3p	CLIP-seq
MIRT2616242	hsa-miR-3148	CLIP-seq
MIRT2616243	hsa-miR-3153	CLIP-seq
MIRT2616244	hsa-miR-3163	CLIP-seq
MIRT2616245	hsa-miR-3189-5p	CLIP-seq
MIRT2616246	hsa-miR-4282	CLIP-seq
MIRT2616247	hsa-miR-4286	CLIP-seq
MIRT2616248	hsa-miR-4668-5p	CLIP-seq
MIRT2616249	hsa-miR-4753-5p	CLIP-seq
MIRT2616250	hsa-miR-4758-3p	CLIP-seq
MIRT2616251	hsa-miR-4777-5p	CLIP-seq
MIRT2616252	hsa-miR-4796-3p	CLIP-seq
MIRT2616253	hsa-miR-498	CLIP-seq
MIRT2616254	hsa-miR-518d-5p	CLIP-seq
MIRT2616255	hsa-miR-519b-5p	CLIP-seq
MIRT2616256	hsa-miR-519c-5p	CLIP-seq
MIRT2616257	hsa-miR-520c-5p	CLIP-seq
MIRT2616258	hsa-miR-526a	CLIP-seq
MIRT2616259	hsa-miR-543	CLIP-seq
MIRT2616260	hsa-miR-548c-3p	CLIP-seq
MIRT2095877	hsa-miR-548t	CLIP-seq
MIRT2616261	hsa-miR-578	CLIP-seq
MIRT2616262	hsa-miR-581	CLIP-seq
MIRT2095878	hsa-miR-586	CLIP-seq
MIRT2616244	hsa-miR-3163	CLIP-seq
MIRT2616245	hsa-miR-3189-5p	CLIP-seq
MIRT2616246	hsa-miR-4282	CLIP-seq
MIRT2616247	hsa-miR-4286	CLIP-seq
MIRT2616250	hsa-miR-4758-3p	CLIP-seq
MIRT2616251	hsa-miR-4777-5p	CLIP-seq
MIRT2616254	hsa-miR-518d-5p	CLIP-seq
MIRT2616255	hsa-miR-519b-5p	CLIP-seq
MIRT2616256	hsa-miR-519c-5p	CLIP-seq
MIRT2616257	hsa-miR-520c-5p	CLIP-seq
MIRT2616258	hsa-miR-526a	CLIP-seq
MIRT2616259	hsa-miR-543	CLIP-seq
MIRT2616261	hsa-miR-578	CLIP-seq
MIRT2616262	hsa-miR-581	CLIP-seq
MIRT2095878	hsa-miR-586	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 31515488, 32296183

Other IDs

• MIM: 617843
• HGNC: 1302
• e!Ensembl: ENSG00000156253

Protein

• UniProt ID: P57060
• Protein name: RWD domain-containing protein 2B
• PDB: 2DAX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05773	RWD	37 → 162	RWD domain	Domain
  PF06544	DUF1115	191 → 313	Protein of unknown function (DUF1115)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MKIELSMQPWNPGYSSEGATAQETYTCPKMIEMEQAEAQLAELDLLASMFPGENELIVND
  QLAVAELKDCIEKKTMEGRSSKVYFTINMNLDVSDEKMAMFSLACILPFKYPAVLPEITV
  RSVLLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYVSRDTSSSPTTGSTV
  QSVDLIFTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFW
  SRLRKLNWKRILIRHREDIPFDGTNDETERQRKFSIFEEKVFSVNGARGNHMDFGQLYQF
  LNTKGCGDVFQMFFGVEGQ

• Sequence length: 319

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations