Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10067
Gene name	Secretory carrier membrane protein 3
Gene symbol	SCAMP3
Synonyms (NCBI Gene)	C1orf3
Chromosome	1
Chromosome location	1q22
Summary	This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein traffic

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Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004952	hsa-let-7b-5p	qRT-PCR	17942906
MIRT032041	hsa-miR-16-5p	Proteomics	18668040
MIRT045441	hsa-miR-149-5p	CLASH	23622248
MIRT695237	hsa-miR-320e	HITS-CLIP	23313552
MIRT695236	hsa-miR-6873-5p	HITS-CLIP	23313552
MIRT695235	hsa-miR-4519	HITS-CLIP	23313552
MIRT695234	hsa-miR-9500	HITS-CLIP	23313552
MIRT695233	hsa-miR-6815-5p	HITS-CLIP	23313552
MIRT695232	hsa-miR-6865-5p	HITS-CLIP	23313552
MIRT695231	hsa-miR-922	HITS-CLIP	23313552
MIRT695230	hsa-miR-4302	HITS-CLIP	23313552
MIRT695229	hsa-miR-132-5p	HITS-CLIP	23313552
MIRT695228	hsa-miR-6134	HITS-CLIP	23313552
MIRT695227	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT695226	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT695225	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT695224	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT695223	hsa-miR-6735-3p	HITS-CLIP	23313552
MIRT695222	hsa-miR-1268a	HITS-CLIP	23313552
MIRT695221	hsa-miR-1268b	HITS-CLIP	23313552
MIRT695220	hsa-miR-3180	HITS-CLIP	23313552
MIRT695219	hsa-miR-3180-3p	HITS-CLIP	23313552
MIRT695218	hsa-miR-3196	HITS-CLIP	23313552
MIRT695217	hsa-miR-6816-5p	HITS-CLIP	23313552
MIRT695216	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695215	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695214	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695213	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695212	hsa-miR-92a-1-5p	HITS-CLIP	23313552
MIRT695211	hsa-miR-891a-3p	HITS-CLIP	23313552
MIRT695210	hsa-miR-663b	HITS-CLIP	23313552
MIRT695209	hsa-miR-644a	HITS-CLIP	23313552
MIRT695208	hsa-miR-1227-5p	HITS-CLIP	23313552
MIRT695207	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT695206	hsa-miR-3940-5p	HITS-CLIP	23313552
MIRT695205	hsa-miR-4507	HITS-CLIP	23313552
MIRT695204	hsa-miR-7108-5p	HITS-CLIP	23313552
MIRT695203	hsa-miR-4260	HITS-CLIP	23313552
MIRT734884	hsa-miR-27a-3p	Luciferase reporter assayWestern blottingqRT-PCR	31554889
MIRT734884	hsa-miR-27a-3p	Luciferase reporter assayWestern blottingqRT-PCR	31554889
MIRT695237	hsa-miR-320e	HITS-CLIP	23313552
MIRT695236	hsa-miR-6873-5p	HITS-CLIP	23313552
MIRT695235	hsa-miR-4519	HITS-CLIP	23313552
MIRT695234	hsa-miR-9500	HITS-CLIP	23313552
MIRT695233	hsa-miR-6815-5p	HITS-CLIP	23313552
MIRT695232	hsa-miR-6865-5p	HITS-CLIP	23313552
MIRT695231	hsa-miR-922	HITS-CLIP	23313552
MIRT695230	hsa-miR-4302	HITS-CLIP	23313552
MIRT695229	hsa-miR-132-5p	HITS-CLIP	23313552
MIRT695228	hsa-miR-6134	HITS-CLIP	23313552
MIRT695227	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT695226	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT695225	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT695224	hsa-miR-885-3p	HITS-CLIP	23313552
MIRT695223	hsa-miR-6735-3p	HITS-CLIP	23313552
MIRT695222	hsa-miR-1268a	HITS-CLIP	23313552
MIRT695221	hsa-miR-1268b	HITS-CLIP	23313552
MIRT695220	hsa-miR-3180	HITS-CLIP	23313552
MIRT695219	hsa-miR-3180-3p	HITS-CLIP	23313552
MIRT695218	hsa-miR-3196	HITS-CLIP	23313552
MIRT695217	hsa-miR-6816-5p	HITS-CLIP	23313552
MIRT695216	hsa-miR-6795-5p	HITS-CLIP	23313552
MIRT695215	hsa-miR-6887-5p	HITS-CLIP	23313552
MIRT695214	hsa-miR-328-5p	HITS-CLIP	23313552
MIRT695213	hsa-miR-6885-5p	HITS-CLIP	23313552
MIRT695212	hsa-miR-92a-1-5p	HITS-CLIP	23313552
MIRT695211	hsa-miR-891a-3p	HITS-CLIP	23313552
MIRT695210	hsa-miR-663b	HITS-CLIP	23313552
MIRT695209	hsa-miR-644a	HITS-CLIP	23313552
MIRT695208	hsa-miR-1227-5p	HITS-CLIP	23313552
MIRT695207	hsa-miR-7109-5p	HITS-CLIP	23313552
MIRT695206	hsa-miR-3940-5p	HITS-CLIP	23313552
MIRT695205	hsa-miR-4507	HITS-CLIP	23313552
MIRT695204	hsa-miR-7108-5p	HITS-CLIP	23313552
MIRT695203	hsa-miR-4260	HITS-CLIP	23313552
MIRT1328196	hsa-miR-1245	CLIP-seq
MIRT1328197	hsa-miR-1268	CLIP-seq
MIRT1328198	hsa-miR-128	CLIP-seq
MIRT1328199	hsa-miR-1297	CLIP-seq
MIRT1328200	hsa-miR-214	CLIP-seq
MIRT1328201	hsa-miR-224	CLIP-seq
MIRT1328202	hsa-miR-26a	CLIP-seq
MIRT1328203	hsa-miR-26b	CLIP-seq
MIRT1328204	hsa-miR-27a	CLIP-seq
MIRT1328205	hsa-miR-27b	CLIP-seq
MIRT1328206	hsa-miR-2964a-5p	CLIP-seq
MIRT1328207	hsa-miR-3159	CLIP-seq
MIRT1328208	hsa-miR-3162-5p	CLIP-seq
MIRT1328209	hsa-miR-3187-3p	CLIP-seq
MIRT1328210	hsa-miR-324-5p	CLIP-seq
MIRT1328211	hsa-miR-3606	CLIP-seq
MIRT1328212	hsa-miR-3619-5p	CLIP-seq
MIRT1328213	hsa-miR-3689a-3p	CLIP-seq
MIRT1328214	hsa-miR-3689c	CLIP-seq
MIRT1328215	hsa-miR-3691-3p	CLIP-seq
MIRT1328216	hsa-miR-3918	CLIP-seq
MIRT1328217	hsa-miR-4274	CLIP-seq
MIRT1328218	hsa-miR-4286	CLIP-seq
MIRT1328219	hsa-miR-4291	CLIP-seq
MIRT1328220	hsa-miR-4300	CLIP-seq
MIRT1328221	hsa-miR-4465	CLIP-seq
MIRT1328222	hsa-miR-4469	CLIP-seq
MIRT1328223	hsa-miR-4529-5p	CLIP-seq
MIRT1328224	hsa-miR-4633-3p	CLIP-seq
MIRT1328225	hsa-miR-4640-5p	CLIP-seq
MIRT1328226	hsa-miR-4652-5p	CLIP-seq
MIRT1328227	hsa-miR-4680-5p	CLIP-seq
MIRT1328228	hsa-miR-4685-5p	CLIP-seq
MIRT1328229	hsa-miR-4690-5p	CLIP-seq
MIRT1328230	hsa-miR-4726-5p	CLIP-seq
MIRT1328231	hsa-miR-4761-3p	CLIP-seq
MIRT1328232	hsa-miR-515-5p	CLIP-seq
MIRT1328233	hsa-miR-562	CLIP-seq
MIRT1328234	hsa-miR-593	CLIP-seq
MIRT1328235	hsa-miR-610	CLIP-seq
MIRT1328236	hsa-miR-644	CLIP-seq
MIRT1328237	hsa-miR-761	CLIP-seq
MIRT1328238	hsa-miR-765	CLIP-seq
MIRT1328239	hsa-miR-769-5p	CLIP-seq
MIRT1328240	hsa-miR-920	CLIP-seq
MIRT1328241	hsa-miR-921	CLIP-seq
MIRT1328242	hsa-miR-935	CLIP-seq
MIRT1328197	hsa-miR-1268	CLIP-seq
MIRT1328198	hsa-miR-128	CLIP-seq
MIRT1328204	hsa-miR-27a	CLIP-seq
MIRT1328205	hsa-miR-27b	CLIP-seq
MIRT1328218	hsa-miR-4286	CLIP-seq
MIRT1328226	hsa-miR-4652-5p	CLIP-seq
MIRT1328227	hsa-miR-4680-5p	CLIP-seq
MIRT1328236	hsa-miR-644	CLIP-seq
MIRT1328198	hsa-miR-128	CLIP-seq
MIRT1328199	hsa-miR-1297	CLIP-seq
MIRT1328200	hsa-miR-214	CLIP-seq
MIRT1328201	hsa-miR-224	CLIP-seq
MIRT1328202	hsa-miR-26a	CLIP-seq
MIRT1328203	hsa-miR-26b	CLIP-seq
MIRT1328204	hsa-miR-27a	CLIP-seq
MIRT1328205	hsa-miR-27b	CLIP-seq
MIRT1328207	hsa-miR-3159	CLIP-seq
MIRT1328209	hsa-miR-3187-3p	CLIP-seq
MIRT1328212	hsa-miR-3619-5p	CLIP-seq
MIRT1328213	hsa-miR-3689a-3p	CLIP-seq
MIRT1328214	hsa-miR-3689c	CLIP-seq
MIRT1328217	hsa-miR-4274	CLIP-seq
MIRT1328218	hsa-miR-4286	CLIP-seq
MIRT1328219	hsa-miR-4291	CLIP-seq
MIRT1328220	hsa-miR-4300	CLIP-seq
MIRT1328221	hsa-miR-4465	CLIP-seq
MIRT1328222	hsa-miR-4469	CLIP-seq
MIRT1328223	hsa-miR-4529-5p	CLIP-seq
MIRT1328226	hsa-miR-4652-5p	CLIP-seq
MIRT1328227	hsa-miR-4680-5p	CLIP-seq
MIRT1328229	hsa-miR-4690-5p	CLIP-seq
MIRT1328233	hsa-miR-562	CLIP-seq
MIRT1328237	hsa-miR-761	CLIP-seq
MIRT1328240	hsa-miR-920	CLIP-seq
MIRT1328197	hsa-miR-1268	CLIP-seq
MIRT1328226	hsa-miR-4652-5p	CLIP-seq
MIRT1328236	hsa-miR-644	CLIP-seq
MIRT1328197	hsa-miR-1268	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0006887	Process	Exocytosis	IBA
GO:0006892	Process	Post-Golgi vesicle-mediated transport	TAS	9378760
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	23418353
GO:0032588	Component	Trans-Golgi network membrane	IBA
GO:0055038	Component	Recycling endosome membrane	IBA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
606913	10565	ENSG00000116521

O14828

Protein name

Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3)

Protein function

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04144	SCAMP	132 → 307	SCAMP family	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, with highest expression in heart and skeletal muscle.

Sequence

MAQSRDGGNPFAEPSELDNPFQDPAVIQHRPSRQYATLDVYNPFETREPPPAYEPPAPAP
LPPPSAPSLQPSRKLSPTEPKNYGSYSTQASAAAATAELLKKQEELNRKAEELDRREREL
QHAALGGTATRQNNWPPLPSFCPVQPCFFQDISMEIPQEFQKTVSTMYYLWMCSTLALLL
NFLACLASFCVETNNGAGFGLSILWVLLFTPCSFVCWYRPMYKAFRSDSSFNFFVFFFIF
FVQDVLFVLQAIGIPGWGFSGWISALVVPKGNTAVSVLMLLVALLFTGIAVLGIVMLKRI
HSLYRRTGASFQKAQQEFAAGVFSNPAVRTAAANAAAGAAENAFRAP

Sequence length

347

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	18277965	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASDB_DG	21102463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	21102463, 28067908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	28067908		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	31554889	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27519163, 29312605		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30754729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29312605		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	33493138	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SCAMP3 (secretory carrier membrane protein 3)