Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10063
Gene name	Cytochrome c oxidase copper chaperone COX17
Gene symbol	COX17
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3q13.33
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochond

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Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045209	hsa-miR-186-5p	CLASH	23622248
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT635877	hsa-miR-1284	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612014	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT612013	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT612012	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT612011	hsa-miR-4251	HITS-CLIP	23824327
MIRT612010	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT612009	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT612008	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612007	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612006	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612005	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT905066	hsa-miR-338-5p	CLIP-seq
MIRT905067	hsa-miR-340	CLIP-seq
MIRT905068	hsa-miR-3692	CLIP-seq
MIRT905069	hsa-miR-3973	CLIP-seq
MIRT905070	hsa-miR-4659a-3p	CLIP-seq
MIRT905071	hsa-miR-4659b-3p	CLIP-seq
MIRT905072	hsa-miR-4778-3p	CLIP-seq
MIRT905073	hsa-miR-520g	CLIP-seq
MIRT905074	hsa-miR-520h	CLIP-seq
MIRT905075	hsa-miR-600	CLIP-seq
MIRT1968430	hsa-miR-1298	CLIP-seq
MIRT1968431	hsa-miR-377	CLIP-seq
MIRT1968432	hsa-miR-873	CLIP-seq
MIRT1968433	hsa-miR-944	CLIP-seq
MIRT1968430	hsa-miR-1298	CLIP-seq
MIRT2204261	hsa-miR-150	CLIP-seq
MIRT2204262	hsa-miR-3133	CLIP-seq
MIRT905069	hsa-miR-3973	CLIP-seq
MIRT2204263	hsa-miR-4511	CLIP-seq
MIRT905072	hsa-miR-4778-3p	CLIP-seq
MIRT905073	hsa-miR-520g	CLIP-seq
MIRT905074	hsa-miR-520h	CLIP-seq
MIRT1968432	hsa-miR-873	CLIP-seq
MIRT1968433	hsa-miR-944	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IEA
GO:0005507	Function	Copper ion binding	TAS	9050918
GO:0005515	Function	Protein binding	IPI	16189514, 18458339, 19182799, 25416956, 29568061, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IDA	19393246
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9050918
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IBA
GO:0005758	Component	Mitochondrial intermembrane space	IDA	19393246
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005758	Component	Mitochondrial intermembrane space	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	9050918
GO:0006825	Process	Copper ion transport	TAS	9050918
GO:0007507	Process	Heart development	IEA
GO:0008047	Function	Enzyme activator activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19393246
GO:0016531	Function	Copper chaperone activity	IBA
GO:0016531	Function	Copper chaperone activity	IEA
GO:0016531	Function	Copper chaperone activity	IMP	19393246
GO:0016531	Function	Copper chaperone activity	ISS
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IBA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IEA
GO:0033617	Process	Mitochondrial cytochrome c oxidase assembly	IMP	19393246
GO:0046872	Function	Metal ion binding	IEA
GO:1903136	Function	Cuprous ion binding	IDA	18093982
GO:1904960	Process	Positive regulation of cytochrome-c oxidase activity	IMP	19393246

MIM	HGNC	e!Ensembl
604813	2264	ENSG00000138495

Q14061

Protein name

Cytochrome c oxidase copper chaperone

Protein function

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions

PDB

2L0Y , 2LGQ , 2RN9 , 2RNB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05051	COX17	18 → 63	Cytochrome C oxidase copper chaperone (COX17)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10982038}.

Sequence

MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALG
FKI

Sequence length

Interactions

View interactions

	KEGG
	Oxidative phosphorylation Metabolic pathways Thermogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEPATITIS, CHRONIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	27711126	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	38078879	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30798618		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	BEFREE	11027508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30798618		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	CTD_human_DG	23624903		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of lung	Lung Cancer	BEFREE	14612491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	CTD_human_DG	23624903		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	14612491		★★★★★ ★☆☆☆☆ Found in Text Mining only

COX17 (cytochrome c oxidase copper chaperone COX17)