Gene Gene information from NCBI Gene database.
Entrez ID 1006
Gene name Cadherin 8
Gene symbol CDH8
Synonyms (NCBI Gene)
Nbla04261
Chromosome 16
Chromosome location 16q21
Summary This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane
miRNA miRNA information provided by mirtarbase database.
216
miRTarBase ID miRNA Experiments Reference
MIRT708314 hsa-miR-3183 HITS-CLIP 19536157
MIRT708313 hsa-miR-4723-3p HITS-CLIP 19536157
MIRT708312 hsa-miR-6769b-3p HITS-CLIP 19536157
MIRT708311 hsa-miR-1304-3p HITS-CLIP 19536157
MIRT613412 hsa-miR-7113-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603008 1767 ENSG00000150394
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P55286
Protein name Cadherin-8
Protein function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00028 Cadherin 67 158 Cadherin domain Domain
PF00028 Cadherin 172 267 Cadherin domain Domain
PF00028 Cadherin 281 383 Cadherin domain Domain
PF00028 Cadherin 396 487 Cadherin domain Domain
PF00028 Cadherin 500 597 Cadherin domain Domain
PF01049 Cadherin_C 645 793 Cadherin cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
Sequence
Sequence length 799
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Adherens junctions interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Autism Spectrum Disorder Autism Pubtator 23879678 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 23879678
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 20972252
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism Pubtator 20972252, 23575222 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 28177435 Associate
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 12209956
★☆☆☆☆
Found in Text Mining only
Cyst Cyst BEFREE 21389276
★☆☆☆☆
Found in Text Mining only
Learning Disabilities Learning Disorders BEFREE 20972252
★☆☆☆☆
Found in Text Mining only
Learning Disabilities Learning disorders Pubtator 20972252 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 28422868
★☆☆☆☆
Found in Text Mining only