SAE1 (SUMO1 activating enzyme subunit 1)

Gene

• Entrez ID: 10055
• Gene name: SUMO1 activating enzyme subunit 1
• Gene symbol: SAE1
• Synonyms (NCBI Gene): AOS1, HSPC140, SUA1, UBLE1A
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUM

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043603	hsa-miR-151a-3p	CLASH	23622248
MIRT042940	hsa-miR-324-3p	CLASH	23622248
MIRT040267	hsa-miR-615-3p	CLASH	23622248
MIRT036348	hsa-miR-1229-3p	CLASH	23622248
MIRT293793	hsa-miR-6816-3p	PAR-CLIP	21572407
MIRT554505	hsa-miR-4687-5p	PAR-CLIP	21572407
MIRT399446	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT554504	hsa-miR-129-1-3p	PAR-CLIP	21572407
MIRT554503	hsa-miR-129-2-3p	PAR-CLIP	21572407
MIRT293790	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT293791	hsa-miR-4779	PAR-CLIP	21572407
MIRT399442	hsa-miR-3651	PAR-CLIP	21572407
MIRT554502	hsa-miR-103b	PAR-CLIP	21572407
MIRT399450	hsa-miR-7976	PAR-CLIP	21572407
MIRT554501	hsa-miR-299-5p	PAR-CLIP	21572407
MIRT293782	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT293786	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT293783	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT293784	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT293788	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT293785	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT293792	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT293789	hsa-miR-4266	PAR-CLIP	21572407
MIRT554500	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT735754	hsa-miR-129-5p	Luciferase reporter assay, qRT-PCR	31933971
MIRT293793	hsa-miR-6816-3p	PAR-CLIP	21572407
MIRT554505	hsa-miR-4687-5p	PAR-CLIP	21572407
MIRT399446	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT554504	hsa-miR-129-1-3p	PAR-CLIP	21572407
MIRT554503	hsa-miR-129-2-3p	PAR-CLIP	21572407
MIRT293790	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT293791	hsa-miR-4779	PAR-CLIP	21572407
MIRT399442	hsa-miR-3651	PAR-CLIP	21572407
MIRT554502	hsa-miR-103b	PAR-CLIP	21572407
MIRT399450	hsa-miR-7976	PAR-CLIP	21572407
MIRT554501	hsa-miR-299-5p	PAR-CLIP	21572407
MIRT293782	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT293786	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT293783	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT293784	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT293788	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT293785	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT293792	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT293789	hsa-miR-4266	PAR-CLIP	21572407
MIRT554500	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT756166	hsa-miR-382-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP), Immunohistochemistry (IHC)	35720620
MIRT1324797	hsa-miR-1254	CLIP-seq
MIRT1324798	hsa-miR-1270	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324801	hsa-miR-129-3p	CLIP-seq
MIRT1324802	hsa-miR-134	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324807	hsa-miR-186	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324809	hsa-miR-203	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324811	hsa-miR-2467-3p	CLIP-seq
MIRT1324812	hsa-miR-2861	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT1324818	hsa-miR-3116	CLIP-seq
MIRT1324819	hsa-miR-3118	CLIP-seq
MIRT1324820	hsa-miR-3133	CLIP-seq
MIRT1324821	hsa-miR-3140-5p	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324823	hsa-miR-3155	CLIP-seq
MIRT1324824	hsa-miR-3155b	CLIP-seq
MIRT1324825	hsa-miR-3164	CLIP-seq
MIRT1324826	hsa-miR-3170	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324828	hsa-miR-342-5p	CLIP-seq
MIRT1324829	hsa-miR-3607-5p	CLIP-seq
MIRT1324830	hsa-miR-3622a-3p	CLIP-seq
MIRT1324831	hsa-miR-3622b-3p	CLIP-seq
MIRT1324832	hsa-miR-3675-5p	CLIP-seq
MIRT1324833	hsa-miR-377	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324836	hsa-miR-4254	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324839	hsa-miR-4328	CLIP-seq
MIRT1324840	hsa-miR-4436b-3p	CLIP-seq
MIRT1324841	hsa-miR-4452	CLIP-seq
MIRT1324842	hsa-miR-4501	CLIP-seq
MIRT1324843	hsa-miR-451b	CLIP-seq
MIRT1324844	hsa-miR-4537	CLIP-seq
MIRT1324845	hsa-miR-4652-3p	CLIP-seq
MIRT1324846	hsa-miR-4664-5p	CLIP-seq
MIRT1324847	hsa-miR-4680-3p	CLIP-seq
MIRT1324848	hsa-miR-4683	CLIP-seq
MIRT1324849	hsa-miR-4684-5p	CLIP-seq
MIRT1324850	hsa-miR-4708-5p	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324852	hsa-miR-4731-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324854	hsa-miR-4768-5p	CLIP-seq
MIRT1324855	hsa-miR-4773	CLIP-seq
MIRT1324856	hsa-miR-4801	CLIP-seq
MIRT1324857	hsa-miR-484	CLIP-seq
MIRT1324858	hsa-miR-494	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT1324861	hsa-miR-502-5p	CLIP-seq
MIRT1324862	hsa-miR-548q	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324864	hsa-miR-620	CLIP-seq
MIRT1324865	hsa-miR-636	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT1324867	hsa-miR-661	CLIP-seq
MIRT1324868	hsa-miR-1182	CLIP-seq
MIRT1324869	hsa-miR-1249	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324872	hsa-miR-1909	CLIP-seq
MIRT1324873	hsa-miR-200b	CLIP-seq
MIRT1324874	hsa-miR-200c	CLIP-seq
MIRT1324875	hsa-miR-3129-3p	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324879	hsa-miR-3914	CLIP-seq
MIRT1324880	hsa-miR-429	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324881	hsa-miR-4312	CLIP-seq
MIRT1324882	hsa-miR-4323	CLIP-seq
MIRT1324883	hsa-miR-4691-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324884	hsa-miR-488	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324887	hsa-miR-873	CLIP-seq
MIRT1324888	hsa-miR-888	CLIP-seq
MIRT2096414	hsa-miR-1207-3p	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT2096417	hsa-miR-150	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT2096419	hsa-miR-188-3p	CLIP-seq
MIRT1324812	hsa-miR-2861	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT1324875	hsa-miR-3129-3p	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT1324821	hsa-miR-3140-5p	CLIP-seq
MIRT2096420	hsa-miR-3189-5p	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324830	hsa-miR-3622a-3p	CLIP-seq
MIRT1324831	hsa-miR-3622b-3p	CLIP-seq
MIRT2096421	hsa-miR-365	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324832	hsa-miR-3675-5p	CLIP-seq
MIRT1324833	hsa-miR-377	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT2096422	hsa-miR-3938	CLIP-seq
MIRT2096423	hsa-miR-4293	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT2096425	hsa-miR-4446-3p	CLIP-seq
MIRT1324841	hsa-miR-4452	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096427	hsa-miR-4492	CLIP-seq
MIRT2096428	hsa-miR-4498	CLIP-seq
MIRT2096429	hsa-miR-4514	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2096431	hsa-miR-4661-3p	CLIP-seq
MIRT1324847	hsa-miR-4680-3p	CLIP-seq
MIRT1324849	hsa-miR-4684-5p	CLIP-seq
MIRT1324883	hsa-miR-4691-3p	CLIP-seq
MIRT2096432	hsa-miR-4692	CLIP-seq
MIRT2096433	hsa-miR-4713-5p	CLIP-seq
MIRT2096434	hsa-miR-4721	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT2096438	hsa-miR-4758-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT1324854	hsa-miR-4768-5p	CLIP-seq
MIRT1324855	hsa-miR-4773	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT2096441	hsa-miR-532-3p	CLIP-seq
MIRT1324862	hsa-miR-548q	CLIP-seq
MIRT2096442	hsa-miR-582-3p	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT1324867	hsa-miR-661	CLIP-seq
MIRT2096443	hsa-miR-762	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT1324868	hsa-miR-1182	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2320613	hsa-miR-1238	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324801	hsa-miR-129-3p	CLIP-seq
MIRT2096417	hsa-miR-150	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT2096419	hsa-miR-188-3p	CLIP-seq
MIRT1324809	hsa-miR-203	CLIP-seq
MIRT2320614	hsa-miR-2115	CLIP-seq
MIRT2320615	hsa-miR-218	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT2320616	hsa-miR-3120-5p	CLIP-seq
MIRT1324825	hsa-miR-3164	CLIP-seq
MIRT2320617	hsa-miR-3183	CLIP-seq
MIRT2096420	hsa-miR-3189-5p	CLIP-seq
MIRT2320618	hsa-miR-323b-3p	CLIP-seq
MIRT2320619	hsa-miR-3647-3p	CLIP-seq
MIRT2096421	hsa-miR-365	CLIP-seq
MIRT2320620	hsa-miR-3663-5p	CLIP-seq
MIRT2320621	hsa-miR-371-5p	CLIP-seq
MIRT2320622	hsa-miR-371b-5p	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT2320623	hsa-miR-3921	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT2320624	hsa-miR-432	CLIP-seq
MIRT2320625	hsa-miR-4421	CLIP-seq
MIRT1324840	hsa-miR-4436b-3p	CLIP-seq
MIRT2320626	hsa-miR-4436b-5p	CLIP-seq
MIRT2096425	hsa-miR-4446-3p	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096427	hsa-miR-4492	CLIP-seq
MIRT2096428	hsa-miR-4498	CLIP-seq
MIRT1324842	hsa-miR-4501	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2320627	hsa-miR-4521	CLIP-seq
MIRT2320628	hsa-miR-4539	CLIP-seq
MIRT2320629	hsa-miR-4633-3p	CLIP-seq
MIRT2320630	hsa-miR-4653-5p	CLIP-seq
MIRT2320631	hsa-miR-4682	CLIP-seq
MIRT2096433	hsa-miR-4713-5p	CLIP-seq
MIRT2096434	hsa-miR-4721	CLIP-seq
MIRT2320632	hsa-miR-4723-3p	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT2096438	hsa-miR-4758-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT2320633	hsa-miR-4765	CLIP-seq
MIRT1324858	hsa-miR-494	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT2320634	hsa-miR-513b	CLIP-seq
MIRT2320635	hsa-miR-516a-3p	CLIP-seq
MIRT2096441	hsa-miR-532-3p	CLIP-seq
MIRT1324865	hsa-miR-636	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT2096443	hsa-miR-762	CLIP-seq
MIRT2320636	hsa-miR-890	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT2096423	hsa-miR-4293	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096429	hsa-miR-4514	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2096432	hsa-miR-4692	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004839	Function	Ubiquitin activating enzyme activity	TAS	10187858
GO:0005515	Function	Protein binding	IPI	10187858, 15660128, 16189514, 20164921, 26496610, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0008047	Function	Enzyme activator activity	TAS	9920803
GO:0008641	Function	Ubiquitin-like modifier activating enzyme activity	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0016925	Process	Protein sumoylation	IBA
GO:0016925	Process	Protein sumoylation	IDA	15660128, 20164921
GO:0016925	Process	Protein sumoylation	IEA
GO:0016925	Process	Protein sumoylation	IMP	21968017
GO:0019948	Function	SUMO activating enzyme activity	IDA	10187858, 20164921
GO:0031510	Component	SUMO activating enzyme complex	IBA
GO:0031510	Component	SUMO activating enzyme complex	IDA	10187858, 15660128, 20164921
GO:0031510	Component	SUMO activating enzyme complex	IEA
GO:0031510	Component	SUMO activating enzyme complex	IPI	15660128
GO:0033235	Process	Positive regulation of protein sumoylation	IDA	10187858
GO:0043008	Function	ATP-dependent protein binding	IDA	10187858
GO:0044388	Function	Small protein activating enzyme binding	IPI	15660128
GO:0046982	Function	Protein heterodimerization activity	IPI	20164921
GO:1903955	Process	Positive regulation of protein targeting to mitochondrion	HMP	24270810

Other IDs

• MIM: 613294
• HGNC: 30660
• e!Ensembl: ENSG00000142230

Protein

• UniProt ID: Q9UBE0
• Protein name: SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]
• Protein function: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue
• PDB: 1Y8Q, 1Y8R, 3KYC, 3KYD, 6CWY, 6CWZ, 6XOG, 6XOH, 6XOI, 8VY5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00899	ThiF	19 → 340	ThiF family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.
• Sequence:

  MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
  KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
  SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
  VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
  FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
  PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

• Sequence length: 346

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autism Spectrum Disorder	Autism	Pubtator	23275889	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39742381	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33477333, 36748193	Associate	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	37705041	Associate	★☆☆☆☆ Found in Text Mining only
Deglutition Disorders	Dysphagia	BEFREE	30863950		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	19544381	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31345225		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33477333	Stimulate	★☆☆☆☆ Found in Text Mining only
Idiopathic Inflammatory Myopathies	Inflammatory Myopathy	BEFREE	29178913		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	39742381	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22157079		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29178913		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	GWASCAT_DG	21833088, 26920376		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Multiple Sclerosis	GWASDB_DG	21833088		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myositis	Myositis	BEFREE	29845587		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22157079, 31345225		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	40302186	Stimulate	★☆☆☆☆ Found in Text Mining only
Skin Diseases	Skin disease	Pubtator	30140893	Associate	★☆☆☆☆ Found in Text Mining only