MICOS10-NBL1 (MICOS10-NBL1 readthrough)

Gene

• Entrez ID: 100532736
• Gene name: MICOS10-NBL1 readthrough
• Gene symbol: MICOS10-NBL1
• Synonyms (NCBI Gene): C1orf151-NBL1, DAN, DAND1, MINOS1-NBL1, NBL1
• Chromosome: 1
• Chromosome location: 1p36.13
• Summary: This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcr

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IC	23063586
GO:0005615	Component	Extracellular space	IDA	11594460
GO:0007165	Process	Signal transduction	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	ISS
GO:0016015	Function	Morphogen activity	IEA
GO:0016015	Function	Morphogen activity	ISS
GO:0030182	Process	Neuron differentiation	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IDA	23063586
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IMP	25561725
GO:0035581	Process	Sequestering of extracellular ligand from receptor	IEA
GO:0035582	Process	Sequestering of BMP in extracellular matrix	IEA
GO:0035582	Process	Sequestering of BMP in extracellular matrix	ISS
GO:0036122	Function	BMP binding	IBA
GO:0036122	Function	BMP binding	IEA
GO:0036122	Function	BMP binding	ISS
GO:0038098	Process	Sequestering of BMP from receptor via BMP binding	IBA
GO:0038098	Process	Sequestering of BMP from receptor via BMP binding	IDA	23063586
GO:0042802	Function	Identical protein binding	IMP	23063586
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	ISS
GO:0048018	Function	Receptor ligand activity	IBA
GO:0048263	Process	Determination of dorsal identity	IEA
GO:0048263	Process	Determination of dorsal identity	ISS
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0090027	Process	Negative regulation of monocyte chemotaxis	IEA
GO:0090027	Process	Negative regulation of monocyte chemotaxis	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG:

TGF-beta signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRONCHOPULMONARY DYSPLASIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arteriosclerosis	Arteriosclerosis	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Arthritis Juvenile	Juvenile arthritis	Pubtator	36167601	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	37794117	Associate	★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone Marrow Diseases	BEFREE	28324923		★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	GWASCAT_DG	30113228		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	35947673	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30831151		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	40624693	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	35947673	Associate	★☆☆☆☆ Found in Text Mining only
Lafora Disease	Lafora Disease	BEFREE	28391039		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	15320962, 28266278		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22948749		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19995712, 29670107		★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	28811280		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12386293, 15980667, 22948749, 28901317, 30442501, 8084583, 8609050, 9862417		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	10811228, 24590653, 28104757, 28500669, 29603574, 8084583, 9324305, 9500977, 9862417		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	19995712, 29603574, 7777541	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28901317		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	15320962, 19995712, 28266278		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	19995712	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	BEFREE	19995712		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	10811228		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22948749		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	27474499	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	37794117	Associate	★☆☆☆☆ Found in Text Mining only
Sleep Apnea, Obstructive	Sleep Apnea	BEFREE	29596467		★☆☆☆☆ Found in Text Mining only
Triglyceride storage disease with ichthyosis	Triglyceride Storage Disease With Ichthyosis	BEFREE	28974936		★☆☆☆☆ Found in Text Mining only