ST20-MTHFS (ST20-MTHFS readthrough)

Gene

• Entrez ID: 100528021
• Gene name: ST20-MTHFS readthrough
• Gene symbol: ST20-MTHFS
• Synonyms (NCBI Gene): MTHFS
• Chromosome: 15
• Chromosome location: 15q25.1
• Summary: This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through tran

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1393231	hsa-miR-1276	CLIP-seq
MIRT1393232	hsa-miR-128	CLIP-seq
MIRT1393233	hsa-miR-1283	CLIP-seq
MIRT1393234	hsa-miR-1305	CLIP-seq
MIRT1393235	hsa-miR-1324	CLIP-seq
MIRT1393236	hsa-miR-141	CLIP-seq
MIRT1393237	hsa-miR-144	CLIP-seq
MIRT1393238	hsa-miR-200a	CLIP-seq
MIRT1393239	hsa-miR-23a	CLIP-seq
MIRT1393240	hsa-miR-23b	CLIP-seq
MIRT1393241	hsa-miR-23c	CLIP-seq
MIRT1393242	hsa-miR-27a	CLIP-seq
MIRT1393243	hsa-miR-27b	CLIP-seq
MIRT1393244	hsa-miR-3148	CLIP-seq
MIRT1393245	hsa-miR-3163	CLIP-seq
MIRT1393246	hsa-miR-3179	CLIP-seq
MIRT1393247	hsa-miR-3662	CLIP-seq
MIRT1393248	hsa-miR-3670	CLIP-seq
MIRT1393249	hsa-miR-3920	CLIP-seq
MIRT1393250	hsa-miR-3942-3p	CLIP-seq
MIRT1393251	hsa-miR-4633-3p	CLIP-seq
MIRT1393252	hsa-miR-4643	CLIP-seq
MIRT1393253	hsa-miR-466	CLIP-seq
MIRT1393254	hsa-miR-4668-5p	CLIP-seq
MIRT1393255	hsa-miR-4687-3p	CLIP-seq
MIRT1393256	hsa-miR-4742-3p	CLIP-seq
MIRT1393257	hsa-miR-4789-3p	CLIP-seq
MIRT1393258	hsa-miR-520d-5p	CLIP-seq
MIRT1393259	hsa-miR-520g	CLIP-seq
MIRT1393260	hsa-miR-520h	CLIP-seq
MIRT1393261	hsa-miR-524-5p	CLIP-seq
MIRT1393262	hsa-miR-622	CLIP-seq
MIRT1393263	hsa-miR-630	CLIP-seq
MIRT1393264	hsa-miR-647	CLIP-seq
MIRT1393265	hsa-miR-9	CLIP-seq
MIRT1393239	hsa-miR-23a	CLIP-seq
MIRT1393240	hsa-miR-23b	CLIP-seq
MIRT1393241	hsa-miR-23c	CLIP-seq
MIRT2118078	hsa-miR-3065-5p	CLIP-seq
MIRT1393247	hsa-miR-3662	CLIP-seq
MIRT1393256	hsa-miR-4742-3p	CLIP-seq
MIRT1393262	hsa-miR-622	CLIP-seq
MIRT1393263	hsa-miR-630	CLIP-seq
MIRT2118079	hsa-miR-944	CLIP-seq
MIRT1393235	hsa-miR-1324	CLIP-seq
MIRT1393236	hsa-miR-141	CLIP-seq
MIRT1393238	hsa-miR-200a	CLIP-seq
MIRT1393239	hsa-miR-23a	CLIP-seq
MIRT1393240	hsa-miR-23b	CLIP-seq
MIRT1393241	hsa-miR-23c	CLIP-seq
MIRT1393245	hsa-miR-3163	CLIP-seq
MIRT2339985	hsa-miR-320e	CLIP-seq
MIRT2339986	hsa-miR-3591-3p	CLIP-seq
MIRT1393247	hsa-miR-3662	CLIP-seq
MIRT1393249	hsa-miR-3920	CLIP-seq
MIRT1393250	hsa-miR-3942-3p	CLIP-seq
MIRT2339987	hsa-miR-4257	CLIP-seq
MIRT2339988	hsa-miR-4670-3p	CLIP-seq
MIRT1393255	hsa-miR-4687-3p	CLIP-seq
MIRT2339989	hsa-miR-4733-3p	CLIP-seq
MIRT1393256	hsa-miR-4742-3p	CLIP-seq
MIRT2339990	hsa-miR-539	CLIP-seq
MIRT1393262	hsa-miR-622	CLIP-seq
MIRT1393263	hsa-miR-630	CLIP-seq
MIRT1393264	hsa-miR-647	CLIP-seq
MIRT2395232	hsa-miR-142-5p	CLIP-seq
MIRT2395233	hsa-miR-340	CLIP-seq
MIRT2339990	hsa-miR-539	CLIP-seq

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG:

One carbon pool by folate
Metabolic pathways
Folate transport and metabolism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anemia, Macrocytic	Anemia	BEFREE	31844630		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	17533396		★☆☆☆☆ Found in Text Mining only
Cerebellar atrophy	Cerebellar atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	18522750		★☆☆☆☆ Found in Text Mining only
Complex partial seizure with impairment of consciousness	Dyscognitive seizures	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Congenital central hypoventilation syndrome	Congenital central hypoventilation syndrome	Pubtator	24894164	Associate	★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	28264803		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	21895484		★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dysautonomia	Dysautonomia	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Epileptic drop attack	Hypotonic seizures	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Esotropia	Esotropia	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Gelastic Epilepsy	Epilepsy	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	28264803	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	18522750		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	18522750	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	17533396	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	17533396		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	BEFREE	30031689		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	19022216		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	17533396		★☆☆☆☆ Found in Text Mining only
Salaam Seizures	Salaam Seizures	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	17533396		★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	17533396	Associate	★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only