RNF103-CHMP3 (RNF103-CHMP3 readthrough)

Gene

• Entrez ID: 100526767
• Gene name: RNF103-CHMP3 readthrough
• Gene symbol: RNF103-CHMP3
• Synonyms (NCBI Gene): CGI149, CHMP3, NEDF, RNF103-VPS24, VPS24, hVps24
• Chromosome: 2
• Chromosome location: 2p11.2
• Summary: This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequenc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT712639	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT712638	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT712637	hsa-miR-4421	HITS-CLIP	19536157
MIRT712636	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT712635	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT712634	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT712633	hsa-miR-3182	HITS-CLIP	19536157
MIRT712632	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT712631	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT712630	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT712629	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT712628	hsa-miR-4303	HITS-CLIP	19536157
MIRT712627	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT712626	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712625	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT572285	hsa-miR-3662	PAR-CLIP	20371350
MIRT572284	hsa-miR-3646	PAR-CLIP	20371350
MIRT572283	hsa-miR-888-5p	PAR-CLIP	20371350
MIRT572282	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT572281	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT572280	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT572279	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT572278	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT572277	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT534708	hsa-miR-34c-3p	PAR-CLIP	21572407
MIRT534707	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT534705	hsa-miR-3065-3p	PAR-CLIP	21572407
MIRT534704	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT534703	hsa-miR-9-5p	PAR-CLIP	21572407
MIRT534702	hsa-miR-5587-5p	PAR-CLIP	21572407
MIRT534700	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT534699	hsa-miR-133b	PAR-CLIP	21572407
MIRT534708	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT534707	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT534706	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT534705	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT534704	hsa-miR-383-3p	PAR-CLIP	22012620
MIRT534703	hsa-miR-9-5p	PAR-CLIP	22012620
MIRT534702	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT534701	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT534700	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT534699	hsa-miR-133b	PAR-CLIP	22012620
MIRT496130	hsa-miR-500b-3p	PAR-CLIP	22291592
MIRT496129	hsa-miR-8064	PAR-CLIP	22291592
MIRT439766	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT439766	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT712639	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT712638	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT712637	hsa-miR-4421	HITS-CLIP	19536157
MIRT712636	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT712635	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT712634	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT712633	hsa-miR-3182	HITS-CLIP	19536157
MIRT712632	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT712631	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT712630	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT712629	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT712628	hsa-miR-4303	HITS-CLIP	19536157
MIRT712627	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT712626	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712625	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT572285	hsa-miR-3662	PAR-CLIP	20371350
MIRT572284	hsa-miR-3646	PAR-CLIP	20371350
MIRT572283	hsa-miR-888-5p	PAR-CLIP	20371350
MIRT572282	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT572281	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT572280	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT572279	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT572278	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT572277	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT534708	hsa-miR-34c-3p	PAR-CLIP	21572407
MIRT534707	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT534705	hsa-miR-3065-3p	PAR-CLIP	21572407
MIRT534704	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT534703	hsa-miR-9-5p	PAR-CLIP	21572407
MIRT534702	hsa-miR-5587-5p	PAR-CLIP	21572407
MIRT534700	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT534699	hsa-miR-133b	PAR-CLIP	21572407
MIRT534708	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT534707	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT534706	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT534705	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT534704	hsa-miR-383-3p	PAR-CLIP	22012620
MIRT534703	hsa-miR-9-5p	PAR-CLIP	22012620
MIRT534702	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT534701	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT534700	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT534699	hsa-miR-133b	PAR-CLIP	22012620
MIRT496130	hsa-miR-500b-3p	PAR-CLIP	22291592
MIRT496129	hsa-miR-8064	PAR-CLIP	22291592

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG:

Endocytosis
Necroptosis

Reactome:

Budding and maturation of HIV virion
Macroautophagy
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Sealing of the nuclear envelope (NE) by ESCRT-III

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HEART FAILURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	37008939	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	37967346	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	35768804	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	24166080		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	16302002		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	30718901		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only
Polyarteritis Nodosa	Polyarteritis Nodosa	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only
POLYARTERITIS NODOSA, CHILDHOOD-ONSET	Polyarteritis Nodosa	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	37358014	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31541468		★☆☆☆☆ Found in Text Mining only