Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10051
Gene name	Structural maintenance of chromosomes 4
Gene symbol	SMC4
Synonyms (NCBI Gene)	CAP-CCAPCSMC-4SMC4L1
Chromosome	3
Chromosome location	3q25.33
Summary	This gene belongs to the `structural maintenance of chromosomes` (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohe

148

Show/Hide all (148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023841	hsa-miR-1-3p	Proteomics	18668040
MIRT024583	hsa-miR-215-5p	Microarray	19074876
MIRT026547	hsa-miR-192-5p	Microarray	19074876
MIRT029636	hsa-miR-26b-5p	Microarray	19088304
MIRT042211	hsa-miR-484	CLASH	23622248
MIRT563670	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT563671	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT563669	hsa-miR-940	PAR-CLIP	20371350
MIRT563668	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT563666	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT563667	hsa-miR-1827	PAR-CLIP	20371350
MIRT563664	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT563665	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT563662	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT563663	hsa-miR-4316	PAR-CLIP	20371350
MIRT563661	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT563660	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT563659	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT563665	hsa-miR-1207-5p	PAR-CLIP	27292025
MIRT563667	hsa-miR-1827	PAR-CLIP	27292025
MIRT563668	hsa-miR-296-3p	PAR-CLIP	27292025
MIRT563663	hsa-miR-4316	PAR-CLIP	27292025
MIRT563660	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT563662	hsa-miR-4763-3p	PAR-CLIP	27292025
MIRT563664	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT563659	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT563661	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT563670	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT563666	hsa-miR-6823-5p	PAR-CLIP	27292025
MIRT563671	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT563669	hsa-miR-940	PAR-CLIP	27292025
MIRT563670	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT563671	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT563669	hsa-miR-940	PAR-CLIP	20371350
MIRT563668	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT563666	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT563667	hsa-miR-1827	PAR-CLIP	20371350
MIRT563664	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT563665	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT563662	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT563663	hsa-miR-4316	PAR-CLIP	20371350
MIRT563661	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT563660	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT563659	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT1372404	hsa-miR-142-5p	CLIP-seq
MIRT1372405	hsa-miR-3647-3p	CLIP-seq
MIRT1372406	hsa-miR-487a	CLIP-seq
MIRT1372407	hsa-miR-561	CLIP-seq
MIRT1372408	hsa-miR-1179	CLIP-seq
MIRT1372409	hsa-miR-1273g	CLIP-seq
MIRT1372410	hsa-miR-140-5p	CLIP-seq
MIRT1372411	hsa-miR-151-3p	CLIP-seq
MIRT1372412	hsa-miR-1912	CLIP-seq
MIRT1372413	hsa-miR-299-5p	CLIP-seq
MIRT1372414	hsa-miR-3143	CLIP-seq
MIRT1372415	hsa-miR-34c-3p	CLIP-seq
MIRT1372416	hsa-miR-4280	CLIP-seq
MIRT1372417	hsa-miR-4436b-3p	CLIP-seq
MIRT1372418	hsa-miR-4528	CLIP-seq
MIRT1372419	hsa-miR-4760-3p	CLIP-seq
MIRT1372420	hsa-miR-4761-3p	CLIP-seq
MIRT1372421	hsa-miR-4764-3p	CLIP-seq
MIRT1372422	hsa-miR-520d-5p	CLIP-seq
MIRT1372423	hsa-miR-524-5p	CLIP-seq
MIRT1372424	hsa-miR-526b	CLIP-seq
MIRT1372425	hsa-miR-543	CLIP-seq
MIRT1372426	hsa-miR-548aa	CLIP-seq
MIRT1372427	hsa-miR-548ac	CLIP-seq
MIRT1372428	hsa-miR-548c-3p	CLIP-seq
MIRT1372429	hsa-miR-548d-3p	CLIP-seq
MIRT1372430	hsa-miR-548z	CLIP-seq
MIRT1372431	hsa-miR-549	CLIP-seq
MIRT1372432	hsa-miR-590-3p	CLIP-seq
MIRT1372433	hsa-miR-618	CLIP-seq
MIRT2110612	hsa-miR-219-5p	CLIP-seq
MIRT2110613	hsa-miR-300	CLIP-seq
MIRT2110614	hsa-miR-374c	CLIP-seq
MIRT2110615	hsa-miR-381	CLIP-seq
MIRT2110616	hsa-miR-4663	CLIP-seq
MIRT2110617	hsa-miR-4725-5p	CLIP-seq
MIRT2110618	hsa-miR-4782-3p	CLIP-seq
MIRT2110619	hsa-miR-4789-5p	CLIP-seq
MIRT2110620	hsa-miR-504	CLIP-seq
MIRT2110621	hsa-miR-655	CLIP-seq
MIRT1372408	hsa-miR-1179	CLIP-seq
MIRT2110622	hsa-miR-1206	CLIP-seq
MIRT2110623	hsa-miR-1225-5p	CLIP-seq
MIRT1372409	hsa-miR-1273g	CLIP-seq
MIRT1372410	hsa-miR-140-5p	CLIP-seq
MIRT1372414	hsa-miR-3143	CLIP-seq
MIRT2110624	hsa-miR-376a	CLIP-seq
MIRT2110625	hsa-miR-376b	CLIP-seq
MIRT1372418	hsa-miR-4528	CLIP-seq
MIRT1372424	hsa-miR-526b	CLIP-seq
MIRT1372425	hsa-miR-543	CLIP-seq
MIRT1372426	hsa-miR-548aa	CLIP-seq
MIRT2110626	hsa-miR-555	CLIP-seq
MIRT2334013	hsa-miR-1279	CLIP-seq
MIRT2110612	hsa-miR-219-5p	CLIP-seq
MIRT2110618	hsa-miR-4782-3p	CLIP-seq
MIRT2334014	hsa-miR-145	CLIP-seq
MIRT2334015	hsa-miR-1825	CLIP-seq
MIRT2334016	hsa-miR-199a-5p	CLIP-seq
MIRT2334017	hsa-miR-199b-5p	CLIP-seq
MIRT2334018	hsa-miR-3180-5p	CLIP-seq
MIRT2334019	hsa-miR-3199	CLIP-seq
MIRT2334020	hsa-miR-338-5p	CLIP-seq
MIRT2110614	hsa-miR-374c	CLIP-seq
MIRT2334021	hsa-miR-421	CLIP-seq
MIRT2334022	hsa-miR-4259	CLIP-seq
MIRT2334023	hsa-miR-4268	CLIP-seq
MIRT1372417	hsa-miR-4436b-3p	CLIP-seq
MIRT2334024	hsa-miR-4448	CLIP-seq
MIRT2334025	hsa-miR-4648	CLIP-seq
MIRT2334026	hsa-miR-4666-3p	CLIP-seq
MIRT2334027	hsa-miR-4709-5p	CLIP-seq
MIRT2334028	hsa-miR-4715-5p	CLIP-seq
MIRT2110617	hsa-miR-4725-5p	CLIP-seq
MIRT2334029	hsa-miR-4736	CLIP-seq
MIRT1372421	hsa-miR-4764-3p	CLIP-seq
MIRT2334030	hsa-miR-4771	CLIP-seq
MIRT2334031	hsa-miR-4793-5p	CLIP-seq
MIRT2334032	hsa-miR-4803	CLIP-seq
MIRT2334033	hsa-miR-499a-5p	CLIP-seq
MIRT2110620	hsa-miR-504	CLIP-seq
MIRT2334034	hsa-miR-576-5p	CLIP-seq
MIRT1372433	hsa-miR-618	CLIP-seq
MIRT2334035	hsa-miR-651	CLIP-seq
MIRT2110621	hsa-miR-655	CLIP-seq
MIRT2334020	hsa-miR-338-5p	CLIP-seq
MIRT2110614	hsa-miR-374c	CLIP-seq
MIRT1372417	hsa-miR-4436b-3p	CLIP-seq
MIRT2334026	hsa-miR-4666-3p	CLIP-seq
MIRT2334030	hsa-miR-4771	CLIP-seq
MIRT2334033	hsa-miR-499a-5p	CLIP-seq
MIRT2334034	hsa-miR-576-5p	CLIP-seq
MIRT2110621	hsa-miR-655	CLIP-seq
MIRT2334013	hsa-miR-1279	CLIP-seq
MIRT2628224	hsa-miR-136	CLIP-seq
MIRT2628225	hsa-miR-2054	CLIP-seq
MIRT2110612	hsa-miR-219-5p	CLIP-seq
MIRT2628226	hsa-miR-3123	CLIP-seq
MIRT2628227	hsa-miR-3925-5p	CLIP-seq
MIRT2628228	hsa-miR-3976	CLIP-seq
MIRT2110617	hsa-miR-4725-5p	CLIP-seq
MIRT2110618	hsa-miR-4782-3p	CLIP-seq
MIRT2110620	hsa-miR-504	CLIP-seq
MIRT2628229	hsa-miR-515-5p	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	TAS	11321372
GO:0000166	Function	Nucleotide binding	IEA
GO:0000280	Process	Nuclear division	IEA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0000794	Component	Condensed nuclear chromosome	ISO
GO:0000796	Component	Condensin complex	IDA	9789013, 11136719
GO:0000796	Component	Condensin complex	IEA
GO:0000796	Component	Condensin complex	NAS	17268547
GO:0000796	Component	Condensin complex	TAS	11850403
GO:0003682	Function	Chromatin binding	IEA
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	9789013, 17113138, 17268547, 26496610, 30021884, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	TAS	11136719
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	11850403
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007076	Process	Mitotic chromosome condensation	IDA	11136719
GO:0010032	Process	Meiotic chromosome condensation	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030261	Process	Chromosome condensation	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0045132	Process	Meiotic chromosome segregation	IEA
GO:0051276	Process	Chromosome organization	IEA
GO:0051301	Process	Cell division	IEA
GO:0051383	Process	Kinetochore organization	IEA
GO:0051984	Process	Positive regulation of chromosome segregation	IEA
GO:0051984	Process	Positive regulation of chromosome segregation	ISO
GO:0098813	Process	Nuclear chromosome segregation	IEA
GO:1905820	Process	Positive regulation of chromosome separation	IEA
GO:1905820	Process	Positive regulation of chromosome separation	ISO
GO:1905821	Process	Positive regulation of chromosome condensation	IDA	17268547
GO:1905821	Process	Positive regulation of chromosome condensation	ISS

MIM	HGNC	e!Ensembl
605575	14013	ENSG00000113810

Q9NTJ3

Protein name

Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)

Protein function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type

PDB

4U4P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02463	SMC_N	83 → 1274	RecF/RecN/SMC N terminal domain	Domain
PF06470	SMC_hinge	612 → 728	SMC proteins Flexible Hinge Domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Higher expression in testis, colon, thymus. {ECO:0000269|PubMed:10319587}.

Sequence

MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE
ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS
NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN
SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP
KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG
EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN
EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK
DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES
REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA
IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL
DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR
QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN
LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME
SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK
ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK
AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA
ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ
IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE
ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY
IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS
LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD
RLIGIYKTYNITKSVAVNPKEIASKGLC

Sequence length

1288

Interactions

View interactions

	Reactome
			Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CLONAL HEMATOPOIESIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (34)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Undifferentiated Leukemia	Leukemia	BEFREE	29043883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21822313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31871499	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32616754, 36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	25422241	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24980149, 31828143, 33540684, 36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36281130	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25422241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25422241, 37945594	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	15761962	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	39528802	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	21904957, 28287612		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35615996	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	29043883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	29043883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22842912, 24980149, 31828143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	LHGDN	17488335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	17488335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	17488335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21822313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	22842912		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	21822313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16585525, 19250639, 22842912, 25422241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21822313, 24980149, 28423514		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33563317, 36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36401386	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	23872305		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21822313		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25093842	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	32586319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33460400, 36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Synovial	Synovial sarcoma	Pubtator	36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	29803706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36719264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SMC4 (structural maintenance of chromosomes 4)