Gene Gene information from NCBI Gene database.
Entrez ID 100507436
Gene name MHC class I polypeptide-related sequence A
Gene symbol MICA
Synonyms (NCBI Gene)
MIC-APERB11.1
Chromosome 6
Chromosome location 6p21.33
Summary This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglo
miRNA miRNA information provided by mirtarbase database.
556
miRTarBase ID miRNA Experiments Reference
MIRT001998 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT004677 hsa-miR-520b flowLuciferase reporter assayqRT-PCR 19109132
MIRT004677 hsa-miR-520b flowLuciferase reporter assayqRT-PCR 19109132
MIRT002551 hsa-miR-373-3p Microarray 15685193
MIRT054070 hsa-miR-302c-3p 5.0 23820258
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
HDAC1 Unknown 17625602
HIF1A Activation 21092233
HSF1 Activation 19139882
NFKB1 Unknown 15494508
RELA Unknown 15494508
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0001913 Process T cell mediated cytotoxicity IDA 10426993
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002418 Process Immune response to tumor cell IDA 10359807
GO:0005515 Function Protein binding IPI 11323699, 21712812
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600169 7090 ENSG00000204520
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q29983
Protein name MHC class I polypeptide-related sequence A (MIC-A)
Protein function Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMe
PDB 1B3J , 1HYR , 7FI5 , 7FI6 , 7FI7 , 7FI8 , 7FI9 , 8TLZ , 8TM0 , 8TM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I 24 200 Class I Histocompatibility antigen, domains alpha 1 and 2 Domain
PF07654 C1-set 208 289 Immunoglobulin C1-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's
Sequence
Sequence length 383
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Natural killer cell mediated cytotoxicity
Kaposi sarcoma-associated herpesvirus infection
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
53
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Adrenocortical carcinoma, hereditary Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATOPIC ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Addison Disease Addison`s Disease BEFREE 10523017, 12021133, 12366785, 19820007
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 21605422, 26940474
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25363527
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 17267578
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 29721369
★☆☆☆☆
Found in Text Mining only
AMR Syndrome Amr syndrome Pubtator 21199204 Associate
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 17102945
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 10717805, 10990233, 8311558, 9174144, 9952031
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ankylosing spondylitis Ankylosing Spondylitis GWASDB_DG 22138694
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Arteriosclerosis Arteriosclerosis BEFREE 28279833
★☆☆☆☆
Found in Text Mining only