CDH7 (cadherin 7)

Gene

• Entrez ID: 1005
• Gene name: Cadherin 7
• Gene symbol: CDH7
• Synonyms (NCBI Gene): CDH7L1
• Chromosome: 18
• Chromosome location: 18q22.1
• Summary: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT725598	hsa-miR-4491	HITS-CLIP	19536157
MIRT725597	hsa-miR-4657	HITS-CLIP	19536157
MIRT725596	hsa-miR-4719	HITS-CLIP	19536157
MIRT725595	hsa-miR-4253	HITS-CLIP	19536157
MIRT725594	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT725593	hsa-miR-376b-5p	HITS-CLIP	19536157
MIRT725592	hsa-miR-376c-5p	HITS-CLIP	19536157
MIRT725591	hsa-miR-3691-5p	HITS-CLIP	19536157
MIRT725590	hsa-miR-8056	HITS-CLIP	19536157
MIRT725589	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT725588	hsa-miR-4752	HITS-CLIP	19536157
MIRT497207	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT497206	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT725587	hsa-miR-4795-3p	HITS-CLIP	19536157
MIRT725586	hsa-miR-4273	HITS-CLIP	19536157
MIRT725585	hsa-miR-7156-5p	HITS-CLIP	19536157
MIRT497203	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT725584	hsa-miR-578	HITS-CLIP	19536157
MIRT725583	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT676638	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT688780	hsa-miR-6089	HITS-CLIP	23313552
MIRT688779	hsa-miR-6087	HITS-CLIP	23313552
MIRT671456	hsa-miR-4767	HITS-CLIP	23313552
MIRT688778	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT688777	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT688776	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT688775	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT688774	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT688773	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT671451	hsa-miR-7977	HITS-CLIP	23313552
MIRT688772	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT688771	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT688770	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT688769	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT688768	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT688767	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT688766	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT688765	hsa-miR-3689c	HITS-CLIP	23313552
MIRT688764	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT688763	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT688762	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT688761	hsa-miR-3122	HITS-CLIP	23313552
MIRT688760	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT688759	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT688758	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT676640	hsa-miR-8485	HITS-CLIP	23824327
MIRT676639	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT676638	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT676637	hsa-miR-3918	HITS-CLIP	23824327
MIRT671460	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT676636	hsa-miR-4284	HITS-CLIP	23824327
MIRT676635	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT676634	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT676633	hsa-miR-3178	HITS-CLIP	23824327
MIRT671451	hsa-miR-7977	HITS-CLIP	23824327
MIRT671465	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT671464	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT671462	hsa-miR-5690	HITS-CLIP	23824327
MIRT671463	hsa-miR-1203	HITS-CLIP	23824327
MIRT671460	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT671461	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT671459	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT671457	hsa-miR-6086	HITS-CLIP	23824327
MIRT671458	hsa-miR-6720-3p	HITS-CLIP	23824327
MIRT671456	hsa-miR-4767	HITS-CLIP	23824327
MIRT671455	hsa-miR-566	HITS-CLIP	23824327
MIRT671454	hsa-miR-1908-5p	HITS-CLIP	23824327
MIRT671453	hsa-miR-663a	HITS-CLIP	23824327
MIRT671452	hsa-miR-6787-5p	HITS-CLIP	23824327
MIRT671451	hsa-miR-7977	HITS-CLIP	23824327
MIRT497211	hsa-miR-4635	PAR-CLIP	22291592
MIRT497210	hsa-miR-9-5p	PAR-CLIP	22291592
MIRT497209	hsa-miR-6081	PAR-CLIP	22291592
MIRT497208	hsa-miR-124-5p	PAR-CLIP	22291592
MIRT497207	hsa-miR-2116-5p	PAR-CLIP	22291592
MIRT497206	hsa-miR-22-5p	PAR-CLIP	22291592
MIRT497205	hsa-miR-203a-3p	PAR-CLIP	22291592
MIRT497204	hsa-miR-6874-5p	PAR-CLIP	22291592
MIRT497203	hsa-miR-4677-5p	PAR-CLIP	22291592
MIRT444975	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT444976	hsa-miR-7845-5p	PAR-CLIP	22100165
MIRT444974	hsa-miR-3126-5p	PAR-CLIP	22100165
MIRT444973	hsa-miR-6875-5p	PAR-CLIP	22100165
MIRT444972	hsa-miR-4419a	PAR-CLIP	22100165
MIRT444971	hsa-miR-4510	PAR-CLIP	22100165
MIRT444970	hsa-miR-6127	PAR-CLIP	22100165
MIRT444969	hsa-miR-6129	PAR-CLIP	22100165
MIRT444968	hsa-miR-6130	PAR-CLIP	22100165
MIRT444967	hsa-miR-6133	PAR-CLIP	22100165
MIRT444966	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT444965	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT444964	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT444963	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT444962	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444961	hsa-miR-487a-5p	PAR-CLIP	22100165
MIRT444960	hsa-miR-487b-5p	PAR-CLIP	22100165
MIRT444975	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT444976	hsa-miR-7845-5p	PAR-CLIP	22100165
MIRT444974	hsa-miR-3126-5p	PAR-CLIP	22100165
MIRT444973	hsa-miR-6875-5p	PAR-CLIP	22100165
MIRT444972	hsa-miR-4419a	PAR-CLIP	22100165
MIRT444971	hsa-miR-4510	PAR-CLIP	22100165
MIRT444970	hsa-miR-6127	PAR-CLIP	22100165
MIRT444969	hsa-miR-6129	PAR-CLIP	22100165
MIRT444968	hsa-miR-6130	PAR-CLIP	22100165
MIRT444967	hsa-miR-6133	PAR-CLIP	22100165
MIRT444966	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT444965	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT444964	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT444963	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT444962	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444961	hsa-miR-487a-5p	PAR-CLIP	22100165
MIRT444960	hsa-miR-487b-5p	PAR-CLIP	22100165
MIRT676638	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT688780	hsa-miR-6089	HITS-CLIP	23313552
MIRT688779	hsa-miR-6087	HITS-CLIP	23313552
MIRT671456	hsa-miR-4767	HITS-CLIP	23313552
MIRT688778	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT688777	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT688776	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT688775	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT688774	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT688773	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT671451	hsa-miR-7977	HITS-CLIP	23313552
MIRT688772	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT688771	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT688770	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT688769	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT688768	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT688767	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT688766	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT688765	hsa-miR-3689c	HITS-CLIP	23313552
MIRT688764	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT688763	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT688762	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT688761	hsa-miR-3122	HITS-CLIP	23313552
MIRT688760	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT688759	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT688758	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT676640	hsa-miR-8485	HITS-CLIP	23824327
MIRT676639	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT676638	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT676637	hsa-miR-3918	HITS-CLIP	23824327
MIRT671460	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT676636	hsa-miR-4284	HITS-CLIP	23824327
MIRT676635	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT676634	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT676633	hsa-miR-3178	HITS-CLIP	23824327
MIRT671451	hsa-miR-7977	HITS-CLIP	23824327
MIRT671465	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT671464	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT671462	hsa-miR-5690	HITS-CLIP	23824327
MIRT671463	hsa-miR-1203	HITS-CLIP	23824327
MIRT671460	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT671461	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT671459	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT671457	hsa-miR-6086	HITS-CLIP	23824327
MIRT671458	hsa-miR-6720-3p	HITS-CLIP	23824327
MIRT671456	hsa-miR-4767	HITS-CLIP	23824327
MIRT671455	hsa-miR-566	HITS-CLIP	23824327
MIRT671454	hsa-miR-1908-5p	HITS-CLIP	23824327
MIRT671453	hsa-miR-663a	HITS-CLIP	23824327
MIRT671452	hsa-miR-6787-5p	HITS-CLIP	23824327
MIRT671451	hsa-miR-7977	HITS-CLIP	23824327
MIRT497211	hsa-miR-4635	PAR-CLIP	22291592
MIRT497210	hsa-miR-9-5p	PAR-CLIP	22291592
MIRT497209	hsa-miR-6081	PAR-CLIP	22291592
MIRT497208	hsa-miR-124-5p	PAR-CLIP	22291592
MIRT497207	hsa-miR-2116-5p	PAR-CLIP	22291592
MIRT497206	hsa-miR-22-5p	PAR-CLIP	22291592
MIRT497205	hsa-miR-203a-3p	PAR-CLIP	22291592
MIRT497204	hsa-miR-6874-5p	PAR-CLIP	22291592
MIRT497203	hsa-miR-4677-5p	PAR-CLIP	22291592
MIRT444975	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT444976	hsa-miR-7845-5p	PAR-CLIP	22100165
MIRT444974	hsa-miR-3126-5p	PAR-CLIP	22100165
MIRT444973	hsa-miR-6875-5p	PAR-CLIP	22100165
MIRT444972	hsa-miR-4419a	PAR-CLIP	22100165
MIRT444971	hsa-miR-4510	PAR-CLIP	22100165
MIRT444970	hsa-miR-6127	PAR-CLIP	22100165
MIRT444969	hsa-miR-6129	PAR-CLIP	22100165
MIRT444968	hsa-miR-6130	PAR-CLIP	22100165
MIRT444967	hsa-miR-6133	PAR-CLIP	22100165
MIRT444966	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT444965	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT444964	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT444963	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT444962	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444961	hsa-miR-487a-5p	PAR-CLIP	22100165
MIRT444960	hsa-miR-487b-5p	PAR-CLIP	22100165
MIRT444975	hsa-miR-5571-5p	PAR-CLIP	22100165
MIRT444976	hsa-miR-7845-5p	PAR-CLIP	22100165
MIRT444974	hsa-miR-3126-5p	PAR-CLIP	22100165
MIRT444973	hsa-miR-6875-5p	PAR-CLIP	22100165
MIRT444972	hsa-miR-4419a	PAR-CLIP	22100165
MIRT444971	hsa-miR-4510	PAR-CLIP	22100165
MIRT444970	hsa-miR-6127	PAR-CLIP	22100165
MIRT444969	hsa-miR-6129	PAR-CLIP	22100165
MIRT444968	hsa-miR-6130	PAR-CLIP	22100165
MIRT444967	hsa-miR-6133	PAR-CLIP	22100165
MIRT444966	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT444965	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT444964	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT444963	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT444962	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444961	hsa-miR-487a-5p	PAR-CLIP	22100165
MIRT444960	hsa-miR-487b-5p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005912	Component	Adherens junction	IBA
GO:0007043	Process	Cell-cell junction assembly	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0008013	Function	Beta-catenin binding	IBA
GO:0016020	Component	Membrane	IEA
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0016342	Component	Catenin complex	IBA
GO:0016477	Process	Cell migration	IBA
GO:0034332	Process	Adherens junction organization	IBA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IBA
GO:0045296	Function	Cadherin binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098609	Process	Cell-cell adhesion	NAS	10861224

Other IDs

• MIM: 605806
• HGNC: 1766
• e!Ensembl: ENSG00000081138

Protein

• UniProt ID: Q9ULB5
• Protein name: Cadherin-7
• Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	52 → 144	Cadherin domain	Domain
  PF00028	Cadherin	158 → 253	Cadherin domain	Domain
  PF00028	Cadherin	267 → 369	Cadherin domain	Domain
  PF00028	Cadherin	382 → 473	Cadherin domain	Domain
  PF00028	Cadherin	486 → 583	Cadherin domain	Domain
  PF01049	Cadherin_C	631 → 779	Cadherin cytoplasmic region	Family

• Sequence:

  MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSRTKRSWVWNQFFVLEEY
  MGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGDIHATKRLDREEQAYYTL
  RAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVPEMSPVGTSVVQVTATDA
  DDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAKDQYLLVIQAKDMVGQNG
  GLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVARIKAADADIGANAEMEYK
  IVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEAANKDADPRFLSLGPFSD
  TTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHDPDSSNSPVRYSIDRNTD
  LERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQVGRGYVAITILDINDNAP
  EFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTDATNNHNFSLKDNKDNT
  ASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYV
  LPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGE
  EDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADV
  DPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQ
  ESLYS

• Sequence length: 785

Pathways

Reactome:

Adherens junctions interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINAL DETACHMENT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations