Gene Gene information from NCBI Gene database.
Entrez ID 1004
Gene name Cadherin 6
Gene symbol CDH6
Synonyms (NCBI Gene)
CAD6KCAD
Chromosome 5
Chromosome location 5p13.3
Summary This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may pl
miRNA miRNA information provided by mirtarbase database.
530
miRTarBase ID miRNA Experiments Reference
MIRT020970 hsa-miR-155-5p Proteomics 20584899
MIRT609026 hsa-miR-6867-5p HITS-CLIP 23824327
MIRT669111 hsa-miR-33a-5p HITS-CLIP 23824327
MIRT669110 hsa-miR-33b-5p HITS-CLIP 23824327
MIRT669109 hsa-miR-3680-3p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
DNMT3A Repression 19070387
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603007 1765 ENSG00000113361
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P55285
Protein name Cadherin-6 (Kidney cadherin) (K-cadherin)
Protein function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
PDB 5VEB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00028 Cadherin 59 150 Cadherin domain Domain
PF00028 Cadherin 164 259 Cadherin domain Domain
PF00028 Cadherin 273 375 Cadherin domain Domain
PF00028 Cadherin 388 479 Cadherin domain Domain
PF00028 Cadherin 492 589 Cadherin domain Domain
PF01049 Cadherin_C 637 784 Cadherin cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
Sequence
Sequence length 790
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Adherens junctions interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CACHEXIA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LARGE ARTERY STROKE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 21297489
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 32427856 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 31932625 Associate
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism Pubtator 25574603 Associate
★☆☆☆☆
Found in Text Mining only
Biliary Tract Cancer Biliary Tract Cancer BEFREE 27593557
★☆☆☆☆
Found in Text Mining only
Biliary Tract Neoplasms Biliary tract neoplasms Pubtator 27593557 Inhibit
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 33899544 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 11414763
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 11720477, 15816561 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 11585719
★☆☆☆☆
Found in Text Mining only