TMEM221 (transmembrane protein 221)

Gene

• Entrez ID: 100130519
• Gene name: Transmembrane protein 221
• Gene symbol: TMEM221
• Synonyms (NCBI Gene): Jiraiya
• Chromosome: 19
• Chromosome location: 19p13.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1435592	hsa-miR-1270	CLIP-seq
MIRT1435593	hsa-miR-3176	CLIP-seq
MIRT1435594	hsa-miR-3922-3p	CLIP-seq
MIRT1435595	hsa-miR-4435	CLIP-seq
MIRT1435596	hsa-miR-4531	CLIP-seq
MIRT1435597	hsa-miR-4654	CLIP-seq
MIRT1435598	hsa-miR-4768-3p	CLIP-seq
MIRT1435599	hsa-miR-4769-5p	CLIP-seq
MIRT1435600	hsa-miR-620	CLIP-seq
MIRT1435601	hsa-miR-769-5p	CLIP-seq
MIRT1554939	hsa-miR-103a	CLIP-seq
MIRT1554940	hsa-miR-107	CLIP-seq
MIRT1554941	hsa-miR-146a	CLIP-seq
MIRT1554942	hsa-miR-146b-5p	CLIP-seq
MIRT1554943	hsa-miR-15a	CLIP-seq
MIRT1554944	hsa-miR-15b	CLIP-seq
MIRT1554945	hsa-miR-16	CLIP-seq
MIRT1554946	hsa-miR-195	CLIP-seq
MIRT1554947	hsa-miR-424	CLIP-seq
MIRT1554948	hsa-miR-497	CLIP-seq
MIRT1554949	hsa-miR-589	CLIP-seq
MIRT2130539	hsa-miR-1238	CLIP-seq
MIRT2130540	hsa-miR-1468	CLIP-seq
MIRT2130541	hsa-miR-203	CLIP-seq
MIRT2130542	hsa-miR-4677-3p	CLIP-seq
MIRT2130543	hsa-miR-4679	CLIP-seq
MIRT2130544	hsa-miR-4694-3p	CLIP-seq
MIRT1554939	hsa-miR-103a	CLIP-seq
MIRT1554940	hsa-miR-107	CLIP-seq
MIRT1554941	hsa-miR-146a	CLIP-seq
MIRT1554942	hsa-miR-146b-5p	CLIP-seq
MIRT1554943	hsa-miR-15a	CLIP-seq
MIRT1554944	hsa-miR-15b	CLIP-seq
MIRT1554945	hsa-miR-16	CLIP-seq
MIRT1554946	hsa-miR-195	CLIP-seq
MIRT1554947	hsa-miR-424	CLIP-seq
MIRT1554948	hsa-miR-497	CLIP-seq
MIRT1554949	hsa-miR-589	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NGB7
• Protein name: Transmembrane protein 221
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15038	Jiraiya	10 → 186	Jiraiya	Family

• Sequence:

  MARSYGGRVLAAMTLLGIAAAVLAALGAQLLFQLQAGRAELRGLRAEGLGQELGAGPGLP
  EDAAGTLLPLAAALAALVLVLGFTCLLLAALCGHLGAELARGPGPRRSDWFLYDCRLLRH
  VALGLFCCGISVYLAALSIYALLLFEIETGAAAASILGSGTLVLVAVLTHTLLRAARAAR
  RGLHELSPPSFEDDLARPAEVSKASPRAQPQQGIHRRTPYSTCPEPGDPFGSMATATAPA
  ALEGGWESSLPASRMHRTLSAGLGHWDGVTHEMRRMLGHRPGSMGKDSTLV

• Sequence length: 291

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations