TRAPPC3L (trafficking protein particle complex subunit 3L)

Gene

• Entrez ID: 100128327
• Gene name: Trafficking protein particle complex subunit 3L
• Gene symbol: TRAPPC3L
• Synonyms (NCBI Gene): BET3L, bA259P20.2
• Chromosome: 6
• Chromosome location: 6q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT717870	hsa-miR-216b-3p	HITS-CLIP	19536157
MIRT717869	hsa-miR-1293	HITS-CLIP	19536157
MIRT717868	hsa-miR-4483	HITS-CLIP	19536157
MIRT652237	hsa-miR-4301	HITS-CLIP	23824327
MIRT652236	hsa-miR-4324	HITS-CLIP	23824327
MIRT652235	hsa-miR-544b	HITS-CLIP	23824327
MIRT652234	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT652233	hsa-miR-3670	HITS-CLIP	23824327
MIRT652232	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT652231	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652230	hsa-miR-1200	HITS-CLIP	23824327
MIRT652229	hsa-miR-4642	HITS-CLIP	23824327
MIRT652228	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT652227	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT652226	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT717870	hsa-miR-216b-3p	HITS-CLIP	19536157
MIRT717869	hsa-miR-1293	HITS-CLIP	19536157
MIRT717868	hsa-miR-4483	HITS-CLIP	19536157
MIRT652237	hsa-miR-4301	HITS-CLIP	23824327
MIRT652236	hsa-miR-4324	HITS-CLIP	23824327
MIRT652235	hsa-miR-544b	HITS-CLIP	23824327
MIRT652234	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT652233	hsa-miR-3670	HITS-CLIP	23824327
MIRT652232	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT652231	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652230	hsa-miR-1200	HITS-CLIP	23824327
MIRT652229	hsa-miR-4642	HITS-CLIP	23824327
MIRT652228	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT652227	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT652226	hsa-miR-96-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21525244
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030008	Component	TRAPP complex	IBA
GO:0030008	Component	TRAPP complex	IDA	21525244
GO:0030008	Component	TRAPP complex	IEA
GO:0033106	Component	Cis-Golgi network membrane	IBA
GO:0048193	Process	Golgi vesicle transport	IEA

Other IDs

• MIM: 614137
• HGNC: 21090
• e!Ensembl: ENSG00000173626

Protein

• UniProt ID: Q5T215
• Protein name: Trafficking protein particle complex subunit 3-like protein (TRAPPC3-like protein) (BET3-like protein)
• Protein function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04051	TRAPP	19 → 167	Transport protein particle (TRAPP) component	Family

• Sequence:

  MSRPAHRRPEYHKINKDLFVLTYGALVAQLCKDYEKDEDVNQYLDKMGYGIGTRLVEDFL
  ARSCVGRCHSYSEIIDIIAQVAFKMYLGITPSVTCNNSSKNEFSLILEKNPLVEFVEELP
  AGRSSLCYCNLLCGIIRGALEMVHLAADVTFLQDRLKGDSVTEIGITFLKKRDEKKYRGK
  K

• Sequence length: 181

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
NEPHROTIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations