Gene Gene information from NCBI Gene database.
Entrez ID 100049587
Gene name Sialic acid binding Ig like lectin 14
Gene symbol SIGLEC14
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19q13.41
miRNA miRNA information provided by mirtarbase database.
256
miRTarBase ID miRNA Experiments Reference
MIRT722655 hsa-miR-543 HITS-CLIP 19536157
MIRT722654 hsa-miR-590-3p HITS-CLIP 19536157
MIRT722653 hsa-miR-4719 HITS-CLIP 19536157
MIRT722652 hsa-miR-3143 HITS-CLIP 19536157
MIRT722651 hsa-miR-302c-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0007155 Process Cell adhesion IBA
GO:0007155 Process Cell adhesion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618132 32926 ENSG00000254415
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q08ET2
Protein name Sialic acid-binding Ig-like lectin 14 (Siglec-14)
Protein function Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 24 140 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 151 224 CD80-like C2-set immunoglobulin domain Domain
PF13895 Ig_2 254 336 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis. {ECO:0000269|PubMed:17012248}.
Sequence
Sequence length 396
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    DAP12 interactions
Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
IGA GLOMERULONEPHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 34208838 Associate
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease, Late Onset Alzheimer disease BEFREE 24841380
★☆☆☆☆
Found in Text Mining only
Arthropathy Arthropathy BEFREE 30779748
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 24841380, 25252903
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 36982588 Associate
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary dysplasia Pubtator 35595912 Associate
★☆☆☆☆
Found in Text Mining only
Chronic Obstructive Airway Disease Chronic Obstructive Pulmonary Disease BEFREE 23519826, 24406871, 24841380
★☆☆☆☆
Found in Text Mining only
Colitis Ulcerative Ulcerative colitis Pubtator 39328405 Associate
★☆☆☆☆
Found in Text Mining only
Dermatologic disorders Dermatologic Disorders BEFREE 30779748
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 34472004 Associate
★☆☆☆☆
Found in Text Mining only