Wolfram syndrome | Gene-Disease Associations & Pathways | GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
WOLFRAM SYNDROME	3463 C0043207 MESH:D014929 MONDO:0018105	WFS1	Causal	—	CTD, ClinGen, Disgenet, Orphanet	Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
WOLFRAM SYNDROME 1	222300 C4551693 MONDO:0009101	WFS1	Causal	26239400	ClinVar, Disgenet, GenCC, HPO, ClinGen	Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
WOLFRAM SYNDROME 2	604928 C1858028 MESH:C565733 MONDO:0011502	CISD2	Causal	17846994 19451219 24833725 25056293 25371195 28335035 29237418 31309279 31391115 31600780 33610659	CTD, ClinVar, Disgenet, HPO, ClinGen	—