Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
VENTRICULAR FIBRILLATION	C0042510 EFO_0004287 MESH:D014693	DSP	Causal	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Apoptotic cleavage of cell adhesion proteins +3 more
		NKX2-5	Causal	—	Disgenet	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
		RYR2	Causal	—	Disgenet	Calcium signaling pathway cAMP signaling pathway Cardiac muscle contraction +14 more
		ACTN2	Unknown	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Platelet degranulation +3 more
		AKAP9	Unknown	—	Disgenet	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		ATP11A	Unknown	39024449	GWAS catalog	Efferocytosis Neutrophil degranulation Ion transport by P-type ATPases
		CACNA2D1	Unknown	—	Disgenet	MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes +7 more
		CACNB2	Unknown	—	Disgenet	MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes +8 more
		DNMT3L	Unknown	39024449	GWAS catalog	—
		DSG2	Unknown	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Apoptotic cleavage of cell adhesion proteins +2 more
		EPO	Unknown	18156309	CTD, Disgenet	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling +8 more
		INS	Unknown	5348156	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +39 more
		KCNE2	Unknown	10219239	CTD, Disgenet	Gastric acid secretion Phase 3 - rapid repolarisation Phase 2 - plateau phase
		KCNE3	Unknown	—	Disgenet	Protein digestion and absorption Phase 3 - rapid repolarisation Phase 2 - plateau phase
		KCNJ2	Unknown	—	Disgenet	Cholinergic synapse Oxytocin signaling pathway Renin secretion +5 more
		KCNJ8	Unknown	19120683	CTD, Disgenet	cGMP-PKG signaling pathway ATP sensitive Potassium channels
		LIPT2	Unknown	—	Disgenet	Lipoic acid metabolism Metabolic pathways Biosynthesis of cofactors +1 more
		MYH6	Unknown	—	Disgenet	cGMP-PKG signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes +7 more
		PDZRN4	Unknown	40465716	GWAS catalog	—
		PKP2	Unknown	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Keratinization +1 more
		PLAU	Unknown	9083243	CTD, Disgenet	NF-kappa B signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer +5 more
		PRICKLE2	Unknown	39024449	GWAS catalog	Wnt signaling pathway
		SCN10A	Unknown	20062061	CTD, Disgenet	Phase 0 - rapid depolarisation
		SCN1B	Unknown	—	Disgenet	Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation
		SLC27A6	Unknown	39024449	GWAS catalog	PPAR signaling pathway Insulin resistance Transport of fatty acids
		SNTA1	Unknown	—	Disgenet	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy +2 more
		TRPM4	Unknown	—	Disgenet	Insulin secretion TRP channels
		TTN	Unknown	—	Disgenet	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy +2 more
VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 1	C2751898 603829	CACNA1C	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
		DPP6	Unknown	—	Disgenet	—
		DSP	Unknown	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Apoptotic cleavage of cell adhesion proteins +3 more
		JPH2	Unknown	—	Disgenet	—
		JUP	Unknown	—	Disgenet	Cytoskeleton in muscle cells Pathways in cancer Transcriptional misregulation in cancer +8 more
		KCNH2	Unknown	21130771 16011830 18692916 15828882 19439805 29085299 16226079 16301704 19340359 25974115 22194679 4676148 29016797 16039272 29759541	Disgenet	Voltage gated Potassium channels Phase 3 - rapid repolarisation
		PKP2	Unknown	—	Disgenet	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Keratinization +1 more
		RBM20	Unknown	—	Disgenet	—
		RYR2	Unknown	—	Disgenet	Calcium signaling pathway cAMP signaling pathway Cardiac muscle contraction +14 more
		SCN5A	Unknown	—	Disgenet, HPO	Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation
		SNTA1	Unknown	—	Disgenet	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy +2 more
		TTN	Unknown	—	Disgenet	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy +2 more
		VCL	Unknown	—	Disgenet	Focal adhesion Adherens junction Leukocyte transendothelial migration +14 more
VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 2	C2751829 MONDO:0013063	DPP6	Causal	—	ClinVar, Disgenet, GenCC	—
VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, TYPE 1	MONDO:0011376	SCN5A	Causal	—	ClinVar	Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation

Ventricular fibrillation

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