Undifferentiated pleomorphic sarcoma

Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis Salmonella infection Primary immunodeficiency Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation +5 more

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

EGFR downregulation

Signaling by BRAF and RAF fusions

Endocytosis TBC/RABGAPs

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Phagosome Efferocytosis PI3K-Akt signaling pathway Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Adherens junction Tight junction Neutrophil extracellular trap formation Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Regulation of actin cytoskeleton Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Pancreatic secretion Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Choline metabolism in cancer Diabetic cardiomyopathy Viral myocarditis Lipid and atherosclerosis Fluid shear stress and atherosclerosis GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Nef and signal transduction NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 NTRK2 activates RAC1 FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Factors involved in megakaryocyte development and platelet production +89 more

Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +3 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +4 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +5 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes +4 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Cellular senescence Vascular smooth muscle contraction Axon guidance VEGF signaling pathway Apelin signaling pathway Focal adhesion Gap junction Signaling pathways regulating pluripotency of stem cells Neutrophil extracellular trap formation C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Long-term potentiation Neurotrophin signaling pathway Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Growth hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Salmonella infection Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +93 more

Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events EML4 and NUDC in mitotic spindle formation +32 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Focal adhesion Adherens junction Platelet activation Leukocyte transendothelial migration Long-term potentiation Neurotrophin signaling pathway Cushing syndrome Pancreatic secretion Renal cell carcinoma Lipid and atherosclerosis Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants +25 more

Th17 cell differentiation Estrogen signaling pathway Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Transcriptional regulation of granulopoiesis +6 more

MAPK signaling pathway Ras signaling pathway Axon guidance Downstream signal transduction EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +5 more

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis Activation of NF-kappaB in B cells +1 more

MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Pathways in cancer Thyroid cancer Non-small cell lung cancer Central carbon metabolism in cancer RAF/MAP kinase cascade RET signaling +6 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Endocytosis mTOR signaling pathway Vascular smooth muscle contraction Wnt signaling pathway TGF-beta signaling pathway Axon guidance Focal adhesion Adherens junction Tight junction Platelet activation NOD-like receptor signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Regulation of actin cytoskeleton Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Pancreatic secretion Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Tuberculosis Human cytomegalovirus infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) Rho GTPase cycle PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases SLIT2:ROBO1 increases RHOA activity +64 more

Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle

mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation +3 more

Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +7 more

Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation

Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO

cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Vascular smooth muscle contraction TGF-beta signaling pathway Axon guidance Focal adhesion Adherens junction Tight junction Platelet activation Leukocyte transendothelial migration Regulation of actin cytoskeleton Oxytocin signaling pathway Pathogenic Escherichia coli infection Shigellosis Yersinia infection Human cytomegalovirus infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs Neutrophil degranulation +25 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum Asparagine N-linked glycosylation +2 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal Cellular senescence Apelin signaling pathway C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Proteoglycans in cancer +8 more

Wnt signaling pathway Regulation of FZD by ubiquitination

Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia

PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway Th17 cell differentiation Thyroid hormone signaling pathway Adipocytokine signaling pathway Parathyroid hormone synthesis, secretion and action Non-alcoholic fatty liver disease Bile secretion Hepatitis C Pathways in cancer Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation Thyroid cancer Small cell lung cancer Non-small cell lung cancer Gastric cancer Lipid and atherosclerosis RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +39 more

Ribosome biogenesis in eukaryotes

Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Citric acid cycle (TCA cycle) +12 more

Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Citric acid cycle (TCA cycle) +12 more

Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Citric acid cycle (TCA cycle) +12 more

Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways Carbon metabolism Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Citric acid cycle (TCA cycle) +12 more

Bacterial invasion of epithelial cells Shigellosis

Bacterial invasion of epithelial cells Shigellosis

Lysine degradation Metabolic pathways PKMTs methylate histone lysines

Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells PKMTs methylate histone lysines +1 more