Subtype of: Sarcoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
undifferentiated pleomorphic sarcoma	MONDO_0002142	TOP1	Unknown	30889380 28481359	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	30889380 8821948 31641593 16538442 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	30889380 36788076	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	30889380	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPM4	Unknown	30889380 36788076	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +5 more
		TPR	Unknown	30062063	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	28481359	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	30889380 36788076	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	30889380	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	30889380 36788076	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	30889380	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	30889380	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC2	Unknown	30889380 28481359 28932590	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	30889380 28481359	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	28481359	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	30889380 36788076	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	30889380	Open Targets	Ub-specific processing proteases
		USP6	Unknown	36788076	Open Targets	—
		USP8	Unknown	36788076	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	30889380 36788076	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	30889380 36788076	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VTI1A	Unknown	30889380	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WIF1	Unknown	30889380	Open Targets	Wnt signaling pathway
		WNK2	Unknown	30889380 36788076	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WT1	Unknown	30889380	Open Targets	Transcriptional misregulation in cancer
		WWTR1	Unknown	30889380 36788076	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo +5 more
		XPA	Unknown	30889380	Open Targets	Platinum drug resistance Nucleotide excision repair Formation of Incision Complex in GG-NER +3 more
		XPO1	Unknown	28481359 36788076	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	36788076	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		YWHAE	Unknown	22223660 36788076	Open Targets	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		ZBTB16	Unknown	36788076	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia +2 more
		ZCCHC8	Unknown	30889380 36788076	Open Targets	—
		ZEB1	Unknown	30889380 36788076	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	30889380 28481359 36788076	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	30889380	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZNF331	Unknown	30889380	Open Targets	Generic Transcription Pathway
		ZNF429	Unknown	30889380 36788076	Open Targets	Generic Transcription Pathway
		ZNF521	Unknown	30889380	Open Targets	—
		ZNRF3	Unknown	30889380	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	30889380	Open Targets	mRNA Splicing - Minor Pathway

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Undifferentiated pleomorphic sarcoma

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