Tourette syndrome

Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation +32 more

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

mRNA surveillance pathway RNA degradation

Regulation of pyruvate dehydrogenase (PDH) complex

mRNA Splicing - Major Pathway

Measles Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production +1 more

mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation +3 more

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases

MicroRNAs in cancer Spry regulation of FGF signaling EGFR downregulation

Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors Tryptophan catabolism +1 more

Phagosome PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Malaria Human papillomavirus infection Signaling by PDGF +5 more

Rap1 signaling pathway Focal adhesion Platelet activation Cytoskeleton in muscle cells Shigellosis Human T-cell leukemia virus 1 infection +3 more

Nucleocytoplasmic transport Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Intraflagellar transport

Hippo signaling pathway Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors +3 more

Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2

Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events +1 more

Antigen processing: Ubiquitination & Proteasome degradation

Fanconi anemia pathway Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway

mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT ligand biogenesis and trafficking +13 more

Generic Transcription Pathway

Generic Transcription Pathway

Generic Transcription Pathway

p53 signaling pathway TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Association with Co-factors Transcriptional activation of cell cycle inhibitor p21 +2 more

Generic Transcription Pathway

Fatty acid degradation Valine, leucine and isoleucine degradation beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways Carbon metabolism Fatty acid metabolism Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA +7 more

Metabolic pathways

ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) +2 more

Mitophagy - animal Autophagy - animal Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Macroautophagy +5 more

Trafficking of myristoylated proteins to the cilium

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Osteoclast differentiation Thyroid hormone signaling pathway Pancreatic secretion Alzheimer disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +16 more

Ion transport by P-type ATPases

Regulation of HSF1-mediated heat shock response

B cell receptor signaling pathway

Transcriptional misregulation in cancer

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway FoxO signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Focal adhesion Natural killer cell mediated cytotoxicity Long-term potentiation Neurotrophin signaling pathway Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Spry regulation of FGF signaling Frs2-mediated activation RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +52 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +34 more

MAPK signaling pathway Calcium signaling pathway Circadian entrainment Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Cushing syndrome +4 more

mRNA surveillance pathway RNA degradation

Measles Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production +1 more

MicroRNAs in cancer Spry regulation of FGF signaling EGFR downregulation

Rap1 signaling pathway Focal adhesion Platelet activation Cytoskeleton in muscle cells Shigellosis Human T-cell leukemia virus 1 infection +3 more