Subtype of: Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
thyroid gland undifferentiated (anaplastic) carcinoma	MONDO_0006468	FH	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FLCN	Unknown	29615459 25295501	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLT3	Unknown	29615459 26878173	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	29615459 26878173	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXL2	Unknown	29615459	Open Targets	SUMOylation of transcription factors
		FOXO3	Unknown	33428730	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXP1	Unknown	29615459	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		GATA1	Unknown	29615459 26878173	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	29615459 26878173	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	25295501	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	29615459 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	33428730	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNAQ	Unknown	25295501	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	29615459 28351340 27785980	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GRIN2A	Unknown	29615459 26878173	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	29615459	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		H3C2	Unknown	33428730	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HGF	Unknown	28481359 26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	25295501	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HRAS	Unknown	12947056 28351340 19487299 24423316 29615459 2648253 1708628 15880523 26878173 17725429 25940539 19706758 38602501 37760447 28481359 27785980	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	29615459	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		IDH1	Unknown	37760447 20171178 20702649	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	29615459 26878173	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IGF2BP2	Unknown	31621921	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKZF1	Unknown	29615459 33428730	Open Targets	—
		IL6ST	Unknown	25295501	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	28481359 26878173	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRF4	Unknown	25295501	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JAK1	Unknown	29615459 28481359 31621921	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	29615459 27785980	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	29615459 28351340	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JUN	Unknown	33428730	Open Targets	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KAT6A	Unknown	33428730	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KCNJ5	Unknown	25295501	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	26878173	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	29615459	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	29615459	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	29615459 28351340 26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KDSR	Unknown	33428730	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KEAP1	Unknown	29615459 28481359 26878173	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KMT2A	Unknown	25295501 29615459 28481359 26878173 33428730	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	29615459 26878173 33428730	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	29615459 28481359 26878173 33428730	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	12947056 28351340 33428730 19487299 24798740 29615459 2648253 18070147 27528624 2183158 38602501 26980298 28481359 27785980 28423545	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS1	Unknown	25295501 33428730	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LOC100506403	Unknown	29615459	Open Targets	—
		LOC124905021	Unknown	28481359 26878173	Open Targets	—
		LRP1B	Unknown	29615459 33428730	Open Targets	—
		LZTR1	Unknown	29615459 25295501	Open Targets	—

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Thyroid gland undifferentiated (anaplastic) carcinoma

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