Thymoma type b3

Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Adherens junction Tight junction Leukocyte transendothelial migration Adherens junctions interactions +4 more

Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer

Polycomb repressive complex

Platinum drug resistance Homologous recombination Fanconi anemia pathway Ubiquitin mediated proteolysis PI3K-Akt signaling pathway MicroRNAs in cancer Breast cancer SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 +19 more

Endocrine resistance Platinum drug resistance Cell cycle p53 signaling pathway Cellular senescence Cushing syndrome Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Pancreatic cancer Glioma Melanoma Bladder cancer Chronic myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Apoptotic factor-mediated response Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Cyclin D associated events in G1 Stabilization of p53 Transcriptional Regulation by VENTX Regulation of RUNX3 expression and activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects +33 more

ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis HDACs deacetylate histones Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription NGF-stimulated transcription +5 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Endocytosis PI3K-Akt signaling pathway Focal adhesion Adherens junction Gap junction JAK-STAT signaling pathway Regulation of actin cytoskeleton GnRH signaling pathway Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Epithelial cell signaling in Helicobacter pylori infection Shigellosis Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants +79 more

Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction Gap junction Cholinergic synapse Long-term depression Insulin secretion GnRH signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Chagas disease Amoebiasis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Acetylcholine regulates insulin secretion G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) +23 more

Maturity onset diabetes of the young

Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Peroxisome Central carbon metabolism in cancer Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import +9 more

EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Cholinergic synapse Prolactin signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis B Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Prolactin receptor signaling Signaling by SCF-KIT RMTs methylate histone arginines Interleukin-3, Interleukin-5 and GM-CSF signaling RAF activation RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cyclin D associated events in G1 Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-27 signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS Interleukin receptor SHC signaling Signaling downstream of RAS mutants Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production +51 more

Lysine degradation Metabolic pathways PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +1 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis +1 more

mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +5 more

mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle Oocyte meiosis PI3K-Akt signaling pathway AMPK signaling pathway Adrenergic signaling in cardiomyocytes TGF-beta signaling pathway Hippo signaling pathway Tight junction T cell receptor signaling pathway Dopaminergic synapse Long-term depression Chagas disease Hepatitis C Human papillomavirus infection Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +52 more

MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Pathways in cancer Thyroid cancer Non-small cell lung cancer Central carbon metabolism in cancer RAF/MAP kinase cascade RET signaling +6 more

ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +3 more

FoxO signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Tight junction Adipocytokine signaling pathway Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes +9 more

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more

Generic Transcription Pathway