Testicular leydig cell tumor | Gene-Disease Associations & Pathways | GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
testicular Leydig cell tumor	MONDO_0003124	ASXL1	Unknown	31147264	Open Targets	Polycomb repressive complex UCH proteinases
		ATR	Unknown	31147264	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		AXIN1	Unknown	31147264	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BCL6	Unknown	31147264	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCORL1	Unknown	30025711 31147264	Open Targets	Polycomb repressive complex
		DNMT3A	Unknown	31147264	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		FGFR3	Unknown	10471491 11294897 12297284 14534538 15772091 16175573 17145761 17344846 17561467 19855393 20543847 31147264 7773297 8754806 9207791 9605748 9887330	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FUBP1	Unknown	31147264	Open Targets	—
		GATA2	Unknown	31147264	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GNAS	Unknown	22016347 9626141	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		KMT2C	Unknown	28481359 30025711 30739914 31147264	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359 31147264	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		MAP2K2	Unknown	31147264	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP3K13	Unknown	31147264	Open Targets	MAPK signaling pathway
		POLE	Unknown	28481359 31147264	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PTCH1	Unknown	30025711 31147264	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTPN11	Unknown	31147264	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		RB1	Unknown	31147264	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RNF43	Unknown	31147264	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		TET2	Unknown	31147264	Open Targets	—
		TP53	Unknown	28481359 30025711 31147264 35128829 37565864	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more