Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
T-cell large granular lymphocyte leukemia	MONDO_0019469	NTRK3	Unknown	35015834	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	35015834	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		PATZ1	Unknown	35015834	Open Targets	—
		PAX3	Unknown	35015834	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	35015834	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PBX1	Unknown	35015834	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PDGFRA	Unknown	35015834	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	35015834	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	35015834	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	35015834	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLAG1	Unknown	35015834	Open Targets	—
		PLCG1	Unknown	35015834	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	35015834	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	35015834	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		POLE	Unknown	35015834	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLQ	Unknown	35015834	Open Targets	HDR through MMEJ (alt-NHEJ)
		POT1	Unknown	35015834	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		PPFIBP1	Unknown	35015834	Open Targets	Receptor-type tyrosine-protein phosphatases
		PRDM1	Unknown	35015834	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	35015834	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PREX2	Unknown	35015834	Open Targets	Regulation of PTEN stability and activity
		PRKD1	Unknown	35015834	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRRX1	Unknown	35015834	Open Targets	—
		PTCH1	Unknown	35015834	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTPN13	Unknown	35015834	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	35015834	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	35015834	Open Targets	Adherens junction Neutrophil degranulation
		PTPRK	Unknown	35015834	Open Targets	EGFR downregulation
		PTPRT	Unknown	24317090 35015834	Open Targets	—
		PWWP2A	Unknown	35015834	Open Targets	—
		RAD21	Unknown	24317090	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD51C	Unknown	35015834	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RALGDS	Unknown	35015834	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		ROBO2	Unknown	35015834	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	35015834	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		RPL10	Unknown	35015834	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	35015834	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RUNX1T1	Unknown	35015834	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SALL4	Unknown	35015834	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SEPTIN9	Unknown	35015834	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETBP1	Unknown	35015834	Open Targets	—
		SETD1B	Unknown	35015834	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SFPQ	Unknown	35015834	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SHTN1	Unknown	35015834	Open Targets	—
		SKI	Unknown	35015834	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SND1	Unknown	35015834	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SRGAP3	Unknown	35015834	Open Targets	Axon guidance Rho GTPase cycle
		SS18L1	Unknown	35015834	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAT3	Unknown	27697773 24797340 22591296 25306898 23207521 35015834 24283217 22859607 24350896 23563237 27761930	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	27697773 23596048 35015834 24573384	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more

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T-cell large granular lymphocyte leukemia

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