Subtype of: Lymphoblastic leukemia

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
T-cell acute lymphoblastic leukemia	MONDO_0004963	HOXA9	Unknown	28157215	Open Targets	Transcriptional misregulation in cancer
		HOXC11	Unknown	36050548	Open Targets	—
		HSP90AB1	Unknown	23263491 27151993	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	19378339 22809434 27428428 34362951 36050548 37554212	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	25595890 26206799 27683039 28671688 34966098 38269085	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	17344859 18408710 19129520 20445578 21356189 21680795 21740479 22237106 22441210 22848414 22868967 22897847 23804397 23930217 25595890 25790293 26206799 27428428 27655895 28157215 28671688 31697823 32378810 33020650 34301788 34362951 36050548 37305720	Open Targets	—
		IL6ST	Unknown	27151993	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IRF4	Unknown	31697823	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		ITK	Unknown	31697823 36050548	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	18362173 18559588 19176360 19764985 19838194 21390130 21551237 21680795 21880637 22237106 22425895 22438252 22675565 23603912 25430085 25595890 25854815 25903014 26206799 27151993 27428428 27655895 27997762 28157215 28410228 28671688 31697823 34301788 36050548	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KAT6A	Unknown	31697823 37305720	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KDM5C	Unknown	23263491 25790293 27428428 36050548	Open Targets	HDMs demethylate histones
		KIT	Unknown	22675565 27428428 28157215 28671688 31697823 36050548 37474833	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	10588740 11526240 11943339 12066788 12116073 12203795 12618768 12661012 12743608 12759932 1423625 14704037 15751040 16924642 16956839 17145626 17268512 17889710 18633615 19144982 19579075 19713226 20051780 20545580 20598370 21681937 21869488 22572394 22581003 23511488 24561789 24624357 25205603 25843568 26264145 26266519 27151993 28671688 31697823 34301788 36050548 8358709 8378076 8527389 8639852 8640717 8703846 9010221	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	25790293 27428428 28671688 31697823 36050548	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	22377896 23603912 25355294 25591849 25595890 25790293 27151993 27428428 27655895 27683039 28671688 31697823 31776129 33020650 34301788 34362951 36050548 36251745 36325357 37305720 37474833	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LARP4B	Unknown	31697823	Open Targets	—
		LATS1	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	25355294 22675565 26206799	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	27151993	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LMO2	Unknown	27428428 28671688 31697823 36050548	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LOC100506403	Unknown	10049054 10463610 10774753 11091202 12621238 12750722 15104290 17889709 18635414 21157892 21828118 22237106 22373549 22675565 24523240 24557455 24870754 24910748 25355294 25595890 25790293 26206799 26681761 27151993 27428428 27655895 28157215 28671688 32378810 36050548 37305720 38567798 7761424 7780150 8751464 8982044 9067587 9207408 9226156 9628428	Open Targets	—
		LRP1B	Unknown	27428428 27655895 27683039 28671688 31697823 34362951 36050548	Open Targets	—
		LSM14A	Unknown	23263491 27151993	Open Targets	—
		MACC1	Unknown	25790293 36050548	Open Targets	—
		MAP2K4	Unknown	22675565 25790293 28157215 31697823 36050548	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAPK1	Unknown	27151993 28671688	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MDM4	Unknown	31697823	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MLLT1	Unknown	11526240 17145626 17268512 19144982 21681937 25790293 28671688 8378076 8527389 8639852 8640717	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	12066788 17268512 36050548	Open Targets	—
		MLLT3	Unknown	17268512 19144982 20051780 21681937 24624357 25843568 27655895 31697823	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MPL	Unknown	22675565 28157215	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	22675565 25595890 26206799 28157215 31697823 36050548	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSI2	Unknown	27655895 28671688 34362951 36050548 37474833	Open Targets	mRNA surveillance pathway
		MTCP1	Unknown	22237106	Open Targets	PI3K-Akt signaling pathway
		MUC16	Unknown	23263491 25790293 27428428 27655895 28671688 31697823 34362951 36050548	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	25790293 27428428 28671688 31697823 36050548	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	27151993 28671688 36050548	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYB	Unknown	23263491 25430085 26206799 26294725 28157215 28671688 31697823 36050548	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYH9	Unknown	27151993 36050548	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYOD1	Unknown	36050548	Open Targets	Spinocerebellar ataxia Myogenesis
		NAB2	Unknown	36050548	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NACA	Unknown	28671688 34362951 36050548	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	23263491 25355294 25790293 27655895 28671688 31697823 34362951 36050548 36251745 37305720 37474833	Open Targets	—
		NCOR2	Unknown	25790293 26294725 26527318 27655895 28157215 28671688 31697823 34362951 36050548	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	20067559 21390130 21680795 22237106 22675565 23508829 23603912 25105841 26206799 27428428 28157215 28671688 31697823 33020650 36050548	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFE2L2	Unknown	27151993 36050548	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFKBIE	Unknown	27151993	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NONO	Unknown	28671688 36050548	Open Targets	—
		NOTCH1	Unknown	15472075 16079893 16270038 16424867 16614245 16707600 17008890 17515920 17575125 17874453 17901244 17928886 18184405 18299449 18322257 18411416 18559588 18688285 18688286 18984862 19055661 19109228 19340001 19458356 19549918 19631984 19794083 20008304 20015880 20067559 21302811 21556011 21880637 21987448 22225590 22237106 22480166 22591685 22675565 23040356 23069254 23263491 23341344 23354995 23603912 23908464 24424791 25355294 25430085 25595890 25903014 25942645 26206799 26294725 26341754 27151993 27347093 27655895 27683039 27997762 28157215 28671688 31697823 33020650 34301788 34362951 36050548 37305720 38269085 38363891	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more

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T-cell acute lymphoblastic leukemia

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