Subtype of: Lymphoblastic leukemia

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
T-cell acute lymphoblastic leukemia	MONDO_0004963	A1CF	Unknown	25790293 27655895 34362951 36050548	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		ABL2	Unknown	27655895 36050548	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACSL3	Unknown	27151993 34362951 36042201	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		AFDN	Unknown	12066788 20545580 21681937 23263491 27655895 28671688 31697823 34362951 36050548 8703846	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AKAP9	Unknown	27151993 28671688 31697823 36050548 37474833	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	19458356 22491738 26206799 26341754 27655895 28157215 28671688 34301788 36050548	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	25595890 28671688	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		ALK	Unknown	22675565 23603912 25790293 27428428 27655895 28157215 31697823 34362951 36050548 37474833 8558920	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANK1	Unknown	25790293 27655895 28671688 31697823 36050548	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		ARAF	Unknown	27655895 31697823 36050548	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGEF10L	Unknown	27655895 28671688 31697823 36042201 36050548	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	27428428 27655895 28671688 31697823 36050548	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID2	Unknown	27151993 31697823 36050548	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASPM	Unknown	25790293 27428428 27655895 28157215 31697823	Open Targets	—
		ASXL1	Unknown	25595890 27428428 27997762 28671688 31697823 36050548 37480761	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	22237106 27428428 28671688 31697823 36050548	Open Targets	Polycomb repressive complex UCH proteinases
		ATR	Unknown	27151993 27428428 31697823 36050548	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		BAP1	Unknown	26294725 27151993	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL11B	Unknown	23263491 26294725 25595890 36050548 26206799 27655895 28671688 38363891 28157215 31697823	Open Targets	Transcriptional misregulation in cancer
		BCL9L	Unknown	27655895 36050548	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	28157215 26294725	Open Targets	—
		BCORL1	Unknown	21989985 25790293 26294725 27428428 28671688 31697823 36050548 36251745	Open Targets	Polycomb repressive complex
		BCR	Unknown	10567681 10602422 10774753 11526240 12116073 18455790 18633615 19579075 19713226 21072049 21681937 21869488 2193202 22226019 22572394 22760091 23511488 25692130 25790293 26264145 26266519 26681761 27428428 36050548 7786792 7873385 7950925 9172811 9760154	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BRAF	Unknown	14603338 21680795 22237106 22675565 26206799 26294725 27428428 27655895 28157215 28481359 28671688 31697823 36050548 37305720 37474833	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	28671688 36050548	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	27151993 36050548	Open Targets	—
		BRD4	Unknown	36050548	Open Targets	—
		BTG1	Unknown	27428428 28157215 36050548	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BTK	Unknown	25790293 28671688 36050548 37474833	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		CANT1	Unknown	26294725 36050548	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CARS1	Unknown	27151993	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CASP8	Unknown	28671688	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CCND2	Unknown	28671688 31697823	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	26294725 27428428 27655895 28157215 28671688 31697823 34301788 36042201 36050548	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CDC73	Unknown	27151993 27428428 27655895 28671688 31697823 36050548	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH10	Unknown	23263491 27655895 31697823 36050548	Open Targets	Adherens junctions interactions
		CDK4	Unknown	22675565	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDKN1B	Unknown	26206799 27655895 28157215 28671688 31697823 36050548	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	10090949 11380395 12130513 12870051 15361874 18299449 18799215 21356189 21680795 22591685 22675565 22994152 23044159 23341344 23900870 25355294 25595890 25903014 26206799 27428428 27655895 28157215 28671688 33020650 34301788 36050548 37305720 37474833 7544647 7606004 7630199 7632931 7632963 7727766 7833469 7882134 7882348 8547074 8555068 8603008 8630377 8637233 8637234 8641406 8665486 8683987	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CDKN2C	Unknown	8637234 28671688	Open Targets	Endocrine resistance Cell cycle Cushing syndrome +6 more
		CEP89	Unknown	28671688 31697823 34362951 36050548	Open Targets	Anchoring of the basal body to the plasma membrane
		CHD2	Unknown	25790293 27151993 27428428 27655895 31697823 36050548	Open Targets	—
		CHD4	Unknown	23263491 27151993 27428428 27655895 31697823 36042201 36050548 36104197 36251745 37305720	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CIC	Unknown	27655895 36050548	Open Targets	Spinocerebellar ataxia
		CLTC	Unknown	23263491 26294725 27151993 27655895 28157215 28671688 34362951 36050548	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CNBD1	Unknown	23263491 27655895 31697823 36050548 37474833	Open Targets	—
		CNTRL	Unknown	25790293 27151993 27428428	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL2A1	Unknown	28671688 36050548	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +14 more
		CREB1	Unknown	27151993 27655895 28671688 36050548	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREB3L1	Unknown	28671688	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more

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T-cell acute lymphoblastic leukemia

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