T-B- severe combined immunodeficiency

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Pathways column key: KEGG Reactome
Disease Term Disease ID Gene Symbol Classification References Source Pathways
T-b- scid
MONDO_0017855
DCLRE1C Unknown
10416610 15731174 16540517 12055248 32092471 12406895 24144642 31393046 11336668 12569164 26476407
Open Targets
LIG4 Unknown
20113890 16357942
Open Targets
RAC2 Unknown
30654050 10758162 31071452 31382036 25512081 21167572 30723080 10961859 32198141 31919089
Open Targets
RAG1 Unknown
16960852 30046960 8810255
Open Targets
RAG2 Unknown
16960852 30046960
Open Targets
All5 Causal0 Unknown5
Related Diseases Diseases that share the most curated genes with T-B- severe combined immunodeficiency.
5 View disease cluster →
Severe combined immunodeficiency autosomal recessive t-cell-negative/b-cell-negative/nk-cell-positive with sensitivity to ionizing radiation 2 shared genesLIG4, DCLRE1C Related via 2 shared genes including LIG4, DCLRE1C. Combined cellular and humoral immune defects with granulomas 2 shared genesRAG1, RAG2 Related via 2 shared genes including RAG1, RAG2. Combined immunodeficiency with granulomatosis 2 shared genesRAG1, RAG2 Related via 2 shared genes including RAG1, RAG2. T-B+ severe combined immunodeficiency 5 shared genesLIG4, RAG1, RAC2, RAG2, DCLRE1C Related via 5 shared genes including LIG4, RAG1, RAC2. Omenn syndrome 4 shared genesLIG4, RAG1, RAG2, DCLRE1C Related via 4 shared genes including LIG4, RAG1, RAG2.